Co And Post Translational Modification Of Proteins
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| Author | : T. Shantha Raju |
| Publisher | : John Wiley & Sons |
| Total Pages | : 304 |
| Release | : 2019-03-15 |
| Genre | : Science |
| ISBN | : 111905334X |
A Comprehensive Guide to Crucial Attributes of Therapeutic Proteins in Biological Pharmaceuticals With this book, Dr. Raju offers a valuable resource for professionals involved in research and development of biopharmaceutical and biosimilar drugs. This is a highly relevant work, as medical practitioners have increasingly turned to biopharmaceutical medicines in their search for safe and reliable treatments for complex diseases, while pharmaceutical researchers seek to expand the availability of biopharmaceuticals and create more affordable biosimilar alternatives. Readers receive a thorough overview of the major co-translational modifications (CTMs) and post-translational modifications (PTMs) of therapeutic proteins relevant to the development of biotherapeutics. The majority of chapters detail individual CTMs and PTMs that may affect the physicochemical, biochemical, biological, pharmacokinetic, immunological, toxicological etc. properties of proteins. In addition, readers are guided on the methodology necessary to analyze and characterize these modifications. Thus, readers gain not only an understanding of CTMs/PTMs, but also the ability to design and assess their own structure-function studies for experimental molecules. Specific features and topics include: Discussion of the research behind and expansion of biopharmaceuticals Twenty chapters detailing relevant CTMs and PTMs of proteins, such as glycosylation, oxidation, phosphorylation, methylation, proteolysis, etc. Each chapter offers an introduction and guide to the mechanisms and biological significance of an individual CTM or PTM, including practical guidance for experiment design and analysis An appendix of biologic pharmaceuticals currently on the market, along with an assessment of their PTMs and overall safety and efficacy This volume will prove a key reference on the shelves of industry and academic researchers involved in the study and development of biochemistry, molecular biology, biopharmaceuticals and proteins in medicine, particularly as biopharmaceuticals and biosimilars become ever more prominent tools in the field of healthcare.
| Author | : Donald J. Graves |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 376 |
| Release | : 1994 |
| Genre | : Literary Criticism |
| ISBN | : |
This work presents the general biological principles--and the chemical and physical concepts-- needed for an understanding of the post- and co-translational modification of proteins, a fundamental topic in the science of protein biochemistry and molecular biology. Examples of the different types of modification reactions (glycosylation, phosphorylation, prenylation, etc.) are presented to illustrate specific points, and the book is intended to serve as a principles-based guide for studying the subject, whether in the classroom or research laboratory. In addition to its value as a timely overview of a broad, vitally important area, the book can be used in advanced courses on signal transduction, enzymology, and protein chemistry, or as a supplementary text for biochemistry or molecular biology.
| Author | : Christopher Walsh |
| Publisher | : Roberts and Company Publishers |
| Total Pages | : 524 |
| Release | : 2006 |
| Genre | : Science |
| ISBN | : 9780974707730 |
Covering the major classes of posttranslational modifications, Posttranslational Modification of Proteins is the first comprehensive treatment of this burgeoning area of proteome diversification.
| Author | : Marc R. Wilkins |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 270 |
| Release | : 1997 |
| Genre | : Medical |
| ISBN | : 9783540627531 |
Introduction to the proteome (K. L. Williams, D. F. Hochstrasser). Two-dimensional electrophoresis: the state of the art and future directions (B. R. Herbert, J.-C. Sanchez, L. Bini). large-scale comparative protein modeling ( M. C. Peitsch, N. Guex); Clinical and biomedical applications of proteomics (D. F. Hochstrasser). Biological applications of proteomics (K. L. Williams, V. Pallini). Conclusions (D. F. Hochstrasser, L. Williams). Index.
| Author | : Christoph Kannicht |
| Publisher | : Humana Press |
| Total Pages | : 0 |
| Release | : 2008-04-01 |
| Genre | : Science |
| ISBN | : 9781588297198 |
This is a fully up-dated and expanded practical guide to protein structure-function relationships. This important area of research is brought up-to-date by the leading scientists in the field. The compilation of detailed protocols focuses on protein function, proteome research and characterization of pharmaceutical proteins, while following the successful format of the Methods in Molecular BiologyTM series. Comprehensive and cutting edge, the book serves as practical guide for researchers working in the field of protein structure-function relationships and the rapidly growing field of proteomics, as well as scientists in the pharmaceutical industries.
| Author | : Christoph Kannicht |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 326 |
| Release | : 2008-02-04 |
| Genre | : Science |
| ISBN | : 1592591817 |
Christoph Kannicht and a panel of highly experienced researchers describe readily reproducible methods for detecting and analyzing the posttranslational modifications of protein, particularly with regard to protein function, proteome research, and the characterization of pharmaceutical proteins.
| Author | : Christoph Kannicht |
| Publisher | : |
| Total Pages | : 327 |
| Release | : 2019 |
| Genre | : Biochemistry |
| ISBN | : 9781493990559 |
The majority of all proteins undergo co- and/or post-translational modifications, crucially altering physical and chemical properties, folding, conformation distribution, stability, activity, and, consequently, the function of the proteins. In Post-Translational Modifications of Proteins: Tools for Functional Proteomics, Third Edition this important area of research is brought up-to-date by the leading scientists in the field. This compilation of detailed protocols focuses on protein function, proteome research and characterization of pharmaceutical proteins, while following the successful format of the Methods in Molecular Biology series. Each chapter provides a brief introduction to the topic, step-by-step laboratory protocols, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting edge, Post-Translational Modifications of Proteins: Tools for Functional Proteomics, Third Edition serves as practical guide for researchers working in the field of protein structure-function relationships and the rapidly growing field of proteomics, as well as scientists in the pharmaceutical industries.
| Author | : John J. Harding |
| Publisher | : CRC Press |
| Total Pages | : 282 |
| Release | : 1991-12-13 |
| Genre | : Medical |
| ISBN | : 9780849341717 |
Post-Translational Modifications of Proteins discusses several important topics of interest to researchers and students in protein chemistry and biochemistry, including the occurrence and function of hydroxylated residues and the three enzymes required for their formation; the damaging effects of reactions between sugars and proteins; ADP-riboosylation of proteins outside the nucleus; and Monod, Wyman, and Changeux's concerted model for allosteric control of enzyme activity exemplified by studies on glycogen phosphorylase. The application of Fast Atom Bombardment Mass Spectometry (FAB-MS) to studies on the structure and biosynthesis of various oligosaccharide moieties in protein is examined, and the understanding of the structural diversity and function of glycoprotein oligosaccharides is discussed in this volume.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 523 |
| Release | : 2001-09-28 |
| Genre | : Science |
| ISBN | : 0080542441 |
This volume examines a number of different proteases, a type of enzyme, that are required in order for the change to a biologically active mature protein to occur. The discussion of these various proteases is rarely undertaken in one volume and will serve as a great resource for scientists studying the group of proteases on signal peptide processing as well as those working on propeptide processing. These areas of research do not normally overlap, and yet they are each of common importance to the same cell processes.
| Author | : Judith P. Klinman |
| Publisher | : Gulf Professional Publishing |
| Total Pages | : 502 |
| Release | : 2001-10-05 |
| Genre | : Medical |
| ISBN | : 9780120342587 |
A cofactor is a component part of many enzymes and functions by uniting with another molecule in order to become active. The use of cofactors to supplement the native amino acids of a protein is essential to maintain the chemical capabilities necessary for organisms to survive. This volume focuses on the significant advances of the past decade in identifying and describing new cofactors--either small molecules or those derived posttranslationally.
