Characterization Of Mitochondr
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| Author | : Mitsuo Tagaya |
| Publisher | : Springer |
| Total Pages | : 254 |
| Release | : 2017-08-16 |
| Genre | : Science |
| ISBN | : 9811045674 |
This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.
| Author | : Lawrence H. Lash |
| Publisher | : Elsevier |
| Total Pages | : 527 |
| Release | : 2013-10-22 |
| Genre | : Science |
| ISBN | : 1483218619 |
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
| Author | : Dario Leister |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1195 |
| Release | : 2007-06-12 |
| Genre | : Medical |
| ISBN | : 1588296679 |
Mitochondrial Genomics and Proteomics Protocols offers a broad collection of methods for studying the molecular biology, function, and features of mitochondria. In the past decade, mitochondrial research has elucidated the important influence of mitochondrial processes on integral cell processes such as apoptosis and cellular aging. This practical guide presents a wide spectrum of mitochondrial methods, each written by specialists with solid experience and intended for implementation by novice and expert researchers alike. Part I introduces major experimental model systems and discusses their specific advantages and limitations for functional analysis of mitochondria. The concise overview of general properties of mitochondrial systems is supplemented by detailed protocols for cultivation of model organisms. Parts II-VI comprise a robust collection of protocols for studying different molecular aspects of mitochondrial functions including: genetics and microbiology, biochemistry, physiology, dynamics and morphology, and functional genomics. Emphasis is placed on new and emerging topics in mitochondrial study, such as the examination of apoptotic effects, fusion and fission of mitochondria, and proteome and transcriptome analysis.
| Author | : Immo E. Scheffler |
| Publisher | : John Wiley & Sons |
| Total Pages | : 377 |
| Release | : 2011-09-20 |
| Genre | : Science |
| ISBN | : 1118209850 |
"This volume inspires. It certainly will be much appreciated by cell biologists all over the world." Quarterly Review of Biology, March 2009 This book is the eagerly awaited second edition of the best-selling Mitochondria, a book widely acknowledged as the first modern, truly comprehensive authored work on the important, scientifically fundamental topic of the cellular organelles known as mitochondria. This new edition brings readers completely up to date on the many significant findings that have occurred in the eight years since the book was first published. As in that seminal first edition, the second edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The new edition provides thorough updates of all literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis-à-vis a broad range of issues in cellular and molecular biology. The book includes detailed descriptions of current and developing technologies around mitochondrial research and discovery, and highlights subjects that are growing, such as the use of proteomics. This book is an invaluable resource for all geneticists, biologists, and educators in life sciences. It is also of interest for advanced students in genetics and molecular biology.
| Author | : Saskia Koene |
| Publisher | : |
| Total Pages | : 135 |
| Release | : 2011 |
| Genre | : |
| ISBN | : 9789081773706 |
| Author | : Mohamed Trebak |
| Publisher | : CRC Press |
| Total Pages | : 326 |
| Release | : 2018-08-06 |
| Genre | : Medical |
| ISBN | : 1351650610 |
All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling. Key selling features: Focuses on smooth muscles of different types Describes ion channel signaling mechanisms Reviews calcium and receptor signaling Includes novel, cutting-edge methodologies Summarizes studies of mice with genetically encoding sensors in smooth muscle Chapter 9 of this book is freely available as a downloadable Open Access PDF under a CC-BY 4.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781498774222_oachapter9.pdf
| Author | : Teresa S. Hawley |
| Publisher | : Springer Nature |
| Total Pages | : 460 |
| Release | : |
| Genre | : |
| ISBN | : 107163738X |
| Author | : Andreas M. Grabrucker |
| Publisher | : |
| Total Pages | : 117 |
| Release | : 2021 |
| Genre | : |
| ISBN | : |
Autism spectrum disorders are developmental disorders. Individuals with autism spectrum disorders develop differently. These differences are usually present in social interaction, communication, and sensory processing, and become visible through a wide variety of behavioral responses that differ from individuals without autism spectrum disorders. Despite significant research efforts, the exact causes of autism spectrum disorders remain poorly understood; however, researchers have gained extensive insights into possible pathomechanisms, even at the molecular level of cells. Many diagnostic criteria have been developed, adapted, and improved. The eight chapters in this book highlight the current state-of-the-art in many areas of autism spectrum disorders. Chapter 1 provides an overview of the epidemiology of autism spectrum disorders and the current knowledge of the underlying pathogenic mechanisms. Chapter 2 summarizes the diagnostic criteria and procedures and highlights present and upcoming therapeutic strategies. Chapter 3 reviews the adverse events and trauma in people with autism spectrum disorders. Chapters 4 and 5 focus on atypical sensory processing, and Chapter 6 discusses the genetic overlap of autism spectrum disorders with other neuropsychiatric disorders such as attention deficit hyperactivity disorder (ADHD), depression, and schizophrenia. Chapter 7 focuses on the contribution of abnormalities in mitochondria, and chapter 8 discusses gut-brain interactions and a potential role for microbiota in autism spectrum disorders. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.
| Author | : Avraham Mayevsky |
| Publisher | : Springer |
| Total Pages | : 285 |
| Release | : 2015-06-20 |
| Genre | : Science |
| ISBN | : 3319166824 |
This book covers both the technological development and biomedical applications of NADH fluorescence. Topics covered include perspectives on the history of monitoring NADH fluorescence, the relationship between mitochondrial function and other functions at the tissue level, responses of NADH to physiological and pathophysiological conditions, monitoring of NADH in the human brain and other organs, and metabolism. It also includes an in-depth look at flavoprotein (Fp) fluorescence and NADH in relation to redox state. This is an ideal book for biomedical engineers, researchers, and graduate students interested in learning the biomedical applications of NADH fluorescence. This book also: Covers multisite monitoring of NADH, as well as multiparametric responses of NADH to physiological and pathophysiological conditions, and monitoring of various organs in various animal models Describes the relationship between brain activation (i.e. epileptic activity and cortical spreading depression) and NADH redox state Presents the effects of hypoxia,hyperbaric hyperoxia, and ischemia on brain NADH fluorescence and other tissue physiological parameters About the Author Avraham Mayevsky, Ph.D. is a Professor Emeritus in theFaculty of Life Sciences and the Brain Research Center at Bar Ilan University, Israel. He has published more than two hundred papers in the field of mitochondrial function and tissue physiology in vivo under pathophysiological conditions.
| Author | : Dejana Mokranjac |
| Publisher | : Humana Press |
| Total Pages | : 409 |
| Release | : 2018-07-20 |
| Genre | : Science |
| ISBN | : 9781493983094 |
This volume compiles a broad range of step-by-step protocols, complementary to the ones published in the first edition of this book, to study various aspects of mitochondrial structure and function in different model organisms, both in vitro and in vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mitochondria: Practical Protocols, Second Edition aims to be useful for beginners as well as for experienced researchers in the field.
