Burkitt Lymphoma Forms Effects Risk Factors Treatment
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| Author | : Patrick Kimuyu |
| Publisher | : GRIN Verlag |
| Total Pages | : 19 |
| Release | : 2017-11-21 |
| Genre | : Medical |
| ISBN | : 3668575886 |
Research Paper (postgraduate) from the year 2017 in the subject Health - Public Health, grade: 1, Egerton University, language: English, abstract: This research paper will provide an overview on Burkitt lymphoma disease and its pathophysiology. Burkitt lymphoma has become one of the most prevalent cancers in the past two decades in which the number of people with the disease has increased, especially in Africa. Research indicates that burkitt lymphoma has emerged to be the fastest growing tumor among humans. Burkitt lymphoma was identified in 1956 by Denis Burkitt, and it is one of the principal forms on non-Hodgkin’s lymphoma, which affect immune cells. Epidemiological reports indicate that, Burkitt lymphoma is more prevalent in malaria endemic regions than other regions although it greatest impact is experienced in Africa where it affects children who are also experiencing episodes of malaria and Epstein-Barr viral infection. Epstein-Barr virus is believed to be the principal cause of infectious mononucleosis, which leads to the transformation of B-cells into tumor cells, especially following malaria episode which weakens the immune system. This is probably the reason as to why 98% of Burkitt lymphoma cases in Africa are linked to Epstein-Barr infection. Elsewhere in the U.S, the incidence of Burkitt lymphoma accounts for about 1,200 people annually in which 59% of all the patients diagnosed with the disease being adults above the age of 40 years. In Burkitt lymphoma, lymphocytes, primarily the B-cells of the immune system which are involved in cell-mediated immune response during pathogenic infections are affected. In most cases, the prevalence of the disease is enhanced by infections which weaken the immune system. For instance, malaria, Epstein-Barr viral infection and HIV are some of the diseases associated with a decrease of the immune system response. In addition, therapies which are immune-suppressive, especially those involved in organ transplantation to prevent transplant rejection and highly-active antiretroviral therapy (HAART) used for HIV/AIDS treatment facilitate the formation of cancerous B-cells. However, the physiology and anatomy of Burkitt lymphoma encompasses diverse aspects compared to other forms cancer.
| Author | : Ann Arvin |
| Publisher | : Cambridge University Press |
| Total Pages | : 1325 |
| Release | : 2007-08-16 |
| Genre | : Medical |
| ISBN | : 1139461648 |
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
| Author | : Howard J. Weinstein |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 296 |
| Release | : 2007-01-20 |
| Genre | : Medical |
| ISBN | : 354068753X |
This is a comprehensive textbook of Hodgkin's and non-Hodgkin's lymphomas written by leaders in the field of childhood lymphomas. It includes clinical, pathologic and molecular biology of each subtype of lymphoma. The pathology chapters are comprehensive and include excellent photographs. The book is at the level of subspecialists in pediatric hematology and oncology, radiation oncology, pediatric surgery and hematopathology.
| Author | : National Academies of Sciences Engineering and Medicine |
| Publisher | : |
| Total Pages | : |
| Release | : 2021-09-09 |
| Genre | : |
| ISBN | : 9780309683494 |
Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.
| Author | : |
| Publisher | : |
| Total Pages | : 194 |
| Release | : 1999 |
| Genre | : Cancer |
| ISBN | : |
| Author | : M. A. Epstein |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 467 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642672361 |
The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.
| Author | : Ahmed H. Al-Salem |
| Publisher | : Springer |
| Total Pages | : 589 |
| Release | : 2014-09-24 |
| Genre | : Medical |
| ISBN | : 331906665X |
Written in a simple point by point style for ease of use, this volume covers all aspects of pediatric surgery with emphasis on important points for diagnosis and management. Each chapter covers a topic with emphasis on the most common conditions in neonatal and general pediatric surgery. The text is well illustrated with clinical, operative, radiological, and histopathological color figures and illustrations. The book also presents some of the rare conditions encountered in pediatric surgery, as well as common pediatric urology conditions. An Illustrated Guide to Pediatric Surgery is a useful reference to pediatric surgeons, specialists, fellows and residents, as well as general surgeons, pediatricians, neonatologists, medical students and interns interested in pediatric surgery.
| Author | : Ajay Vora |
| Publisher | : Springer |
| Total Pages | : 345 |
| Release | : 2017-04-21 |
| Genre | : Medical |
| ISBN | : 3319397087 |
This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
| Author | : |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2023 |
| Genre | : |
| ISBN | : 9781914948060 |
| Author | : Anne Le |
| Publisher | : Springer |
| Total Pages | : 186 |
| Release | : 2018-06-26 |
| Genre | : Medical |
| ISBN | : 331977736X |
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
