Brain Glycogen Metabolism
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| Author | : Mauro DiNuzzo |
| Publisher | : Springer Nature |
| Total Pages | : 443 |
| Release | : 2019-10-31 |
| Genre | : Medical |
| ISBN | : 3030274802 |
This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease.
| Author | : Unesco |
| Publisher | : |
| Total Pages | : |
| Release | : |
| Genre | : |
| ISBN | : |
| Author | : M.Z.M. Ibrahim |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 144 |
| Release | : 2013-12-11 |
| Genre | : Medical |
| ISBN | : 3642868754 |
The glycogen content of normal mammalian CNS is small when compared with that of some other mammalian tissues such as liver and muscle. Nevertheless, this glycogen content normally comprises at least one quarter of its total reserve of energy, the rest being adenosine triphosphate (ATP), phosphocreatine and glucose. Since this glycogen undergoes a turnover 50-100 times that of brain lipids, and exceeds by several orders of magnitude that of liver glycogen, it most likely plays a dynamic role in the metabolism of brain, Gatfield et al. (1966), Prasannan and Subrahmanyam (1968b), Brunner et al. (1971), Edwards and Rogers (1972) and Watanabe and Passonneau (1973). Glycogen also has an unequal distribution in the normal mammalian brain and spinal cord (Shimizu and Kumamoto, 1952; Shimizu and Okada, 1957; Friede, 1966; Shanthaveerappa et al., 1966; Ibrahim etal., 1970a), and it is possible that areas showing more glycogen "are inherently vulnerable and that their extra glycogen is an added protective mechanism" (Ibrahim, 1972). However, this is probably not the only explanation for the unequal distribution of glycogen since it is suggested for instance that neuronal glycogen may be normally impli cated in the process of synaptic transmission (Shanthaveerappa et al., 1966; Drummond and Bellward, 1970) and that retinal glycogen plays a role in the normal dark-light adaptation sequence (Shimizu and Maeda, 1953). Also, a wide variety of physiological, pathological and experimental conditions leads to a common response in the CNS, namely, accumulation of glycogen
| Author | : Johannes Hirrlinger |
| Publisher | : Humana Press |
| Total Pages | : 0 |
| Release | : 2014-09-16 |
| Genre | : Medical |
| ISBN | : 9781493910588 |
Brain Energy Metabolism addresses its challenging subject by presenting diverse technologies allowing for the investigation of brain energy metabolism on different levels of complexity. Model systems are discussed, starting from the reductionist approach like primary cell cultures which allow assessing of the properties and functions of a single brain cell type with many different types of analysis, however, at the expense of neglecting the interaction between cell types in the brain. On the other end, analysis in animals and humans in vivo is discussed, maintaining the full complexity of the tissue and the organism but making high demands on the methods of analysis. Written for the popular Neuromethods series, chapters include the kind of detailed description and key implementation advice that aims to support reproducible results in the lab. Meticulous and authoritative, Brain Energy Metabolism provides an ideal guide for researchers interested in brain energy metabolism with the hope of stimulating more research in this exciting and very important field.
| Author | : Staci A. Weaver |
| Publisher | : |
| Total Pages | : 113 |
| Release | : 2011 |
| Genre | : Brain |
| ISBN | : |
| Author | : Anne Le |
| Publisher | : Springer |
| Total Pages | : 186 |
| Release | : 2018-06-26 |
| Genre | : Medical |
| ISBN | : 331977736X |
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
| Author | : Cody S. Bennett |
| Publisher | : |
| Total Pages | : 59 |
| Release | : 2017 |
| Genre | : Brain |
| ISBN | : |
| Author | : N. V. Bhagavan |
| Publisher | : Academic Press |
| Total Pages | : 1068 |
| Release | : 2002 |
| Genre | : Medical |
| ISBN | : 0120954400 |
This text presents the fundamentals of biochemistry and related topics for all those pursuing medical or other health-related fields such as clinical chemistry, medical technology, or pharmacology.
| Author | : Charles Frederick Saller |
| Publisher | : |
| Total Pages | : 368 |
| Release | : 1979 |
| Genre | : Catecholamines |
| ISBN | : |
| Author | : John W. Pelley, PhD |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 254 |
| Release | : 2011-11-30 |
| Genre | : Medical |
| ISBN | : 0323074464 |
Effectively merge basic science and clinical skills with Elsevier's Integrated Review Biochemistry, by John W. Pelley, PhD. This concise, high-yield title in the popular Integrated Review Series focuses on the core knowledge in biochemistry while linking that information to related concepts from other basic science disciplines. Case-based questions at the end of each chapter enable you to gauge your mastery of the material, and a color-coded format allows you to quickly find the specific guidance you need. Online access via www.studentconsult.com - included with your purchase - allows you to conveniently access the book's complete text and illustrations online as well as relevant content from other Student Consult titles. This concise and user-friendly reference provides crucial guidance for the early years of medical training and USMLE preparation. Spend more time reviewing and less time searching thanks to an extremely focused, "high-yield" presentation. Gauge your mastery of the material and build confidence with both case-based, andUSMLE-style questions that provide effective chapter review and quick practice for your exams. Access the full contents online at www.studentconsult.com where you'll find the complete text and illustrations, "Integration Links" to bonus content in other Student Consult titles, an interactive community center with a wealth of additional resources, and much more! Grasp and retain vital concepts more easily thanks to a color-coded format, succinct,text, key concept boxes, and dynamic illustrations that facilitate learning in a highly visual approach. Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material. Great for visual learners!
