Behavioral Genetics Of The Mouse
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Author | : Wim E. Crusio |
Publisher | : Cambridge University Press |
Total Pages | : 361 |
Release | : 2013-04-25 |
Genre | : Science |
ISBN | : 1107355575 |
The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Author | : Nicole C. Nelson |
Publisher | : University of Chicago Press |
Total Pages | : 262 |
Release | : 2018-04-04 |
Genre | : Science |
ISBN | : 022654611X |
Mice are used as model organisms across a wide range of fields in science today—but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior, Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson’s extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much—if not more—about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm.
Author | : Douglas Wahlsten |
Publisher | : Academic Press |
Total Pages | : 305 |
Release | : 2010-11-25 |
Genre | : Nature |
ISBN | : 0123756758 |
Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level. - A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test - Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas - Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully
Author | : Valerie S. Knopik |
Publisher | : |
Total Pages | : 550 |
Release | : 2018 |
Genre | : Behavior genetics |
ISBN | : 9781319174927 |
Author | : Philip David Zelazo |
Publisher | : Oxford University Press |
Total Pages | : 1049 |
Release | : 2013-03-21 |
Genre | : Medical |
ISBN | : 0199958459 |
This handbook provides a comprehensive survey of what is now known about psychological development, from birth to biological maturity, and it highlights how cultural, social, cognitive, neural, and molecular processes work together to yield human behavior and changes in human behavior.
Author | : Wim E. Crusio |
Publisher | : Cambridge University Press |
Total Pages | : 471 |
Release | : 2014-09-25 |
Genre | : Psychology |
ISBN | : 1107044456 |
A comprehensive and critical overview of the major genetically modified mouse lines used to model human neurobehavioral disorders.
Author | : Jerry J. Buccafusco |
Publisher | : CRC Press |
Total Pages | : 341 |
Release | : 2000-08-29 |
Genre | : Medical |
ISBN | : 1420041819 |
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Author | : Terence Bazzett |
Publisher | : Sinauer |
Total Pages | : 0 |
Release | : 2008-11-30 |
Genre | : Psychology |
ISBN | : 9780878930494 |
This text guides readers through an orderly sequence of related topics from the field, from the molecular structure and function of DNA to how DNA controls protein development and the neural processes that underlie both normal and abnormal behaviour. Though focused primarily on human research, animal models are also included.
Author | : Jonathan Flint |
Publisher | : OUP Oxford |
Total Pages | : 0 |
Release | : 2010-01-28 |
Genre | : Psychology |
ISBN | : 9780199559909 |
This book is a unique introduction to behavioral genetics, which offers unparalleled insights into how the topic is probed using evidence from humans and the major model organisms. It also demonstrates the major impact that neurobiology is having on our understanding of the field, to give a true depiction of behavioral genetics in the 21st century.
Author | : Robert T. Gerlai |
Publisher | : Academic Press |
Total Pages | : 710 |
Release | : 2018-04-24 |
Genre | : Science |
ISBN | : 0128041161 |
Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. - Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials - Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior - Written and edited by leading international experts