The report shows progress made on various indicators related to three overarching categories: technical expected results, application of organizational core values and managerial performance. Ultimately, TDR’s outputs and outcomes contribute to health impact, measured through the achievement of Sustainable Development Goals (SDGs) and the World Health Organization’s (WHO) Thirteenth General Programme of Work (GPW13) triple billion targets. Given the adoption of the Sustainable Development Goals by the global community in 2016, TDR developed its 2018-2023 strategy to showcase the Programme’s unique contribution, through research, capacity strengthening and global engagement, to improved health, quality education, enhanced partnerships and other relevant SDG targets guiding international development work over the next 15 years. The Performance Framework (including a revised set of indicators), which is aligned with TDR’s 2018-2023 strategy, the GPW13 strategic objectives and SDG targets, has been in place since 2018.