Antibiotic Optimization

Antibiotic Optimization
Author: Robert C. Owens
Publisher: CRC Press
Total Pages: 684
Release: 2004-11-04
Genre: Medical
ISBN: 0203996925

This book focuses on topics ranging from the economics of drug-resistant infections and the management of antimicrobial use to new information on methods to optimize the selection, route of administration, dosing, and duration of antimicrobial therapies for common infections. In addition to offering ideas on studied programmatic approaches for judi

Treating Infectious Diseases in a Microbial World

Treating Infectious Diseases in a Microbial World
Author: National Research Council
Publisher: National Academies Press
Total Pages: 102
Release: 2006-01-03
Genre: Medical
ISBN: 0309180686

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

The Use of Drugs in Food Animals

The Use of Drugs in Food Animals
Author: National Research Council
Publisher: National Academies Press
Total Pages: 276
Release: 1999-01-12
Genre: Medical
ISBN: 0309175771

The use of drugs in food animal production has resulted in benefits throughout the food industry; however, their use has also raised public health safety concerns. The Use of Drugs in Food Animals provides an overview of why and how drugs are used in the major food-producing animal industriesâ€"poultry, dairy, beef, swine, and aquaculture. The volume discusses the prevalence of human pathogens in foods of animal origin. It also addresses the transfer of resistance in animal microbes to human pathogens and the resulting risk of human disease. The committee offers analysis and insight into these areas: Monitoring of drug residues. The book provides a brief overview of how the FDA and USDA monitor drug residues in foods of animal origin and describes quality assurance programs initiated by the poultry, dairy, beef, and swine industries. Antibiotic resistance. The committee reports what is known about this controversial problem and its potential effect on human health. The volume also looks at how drug use may be minimized with new approaches in genetics, nutrition, and animal management.

Antimicrobial Stewardship

Antimicrobial Stewardship
Author: Matthew Laundy
Publisher: Oxford University Press
Total Pages: 177
Release: 2016
Genre: Medical
ISBN: 0198758790

Antibiotic resistance threatens the effective prevention and treatment of infections. Antimicrobial Stewardship provides a practical guide on this growing area, supported by the review of the available evidence, including example case studies.

Antimicrobial Stewardship

Antimicrobial Stewardship
Author: Kerry LaPlante
Publisher: CABI
Total Pages: 451
Release: 2016-12-23
Genre: Medical
ISBN: 1780644396

In an age where antimicrobial resistance amongst pathogens grows more prevalent, particularly in the hospital setting, antimicrobial stewardship is an evidence-based, proven measure in the battle against resistance and infection. This single comprehensive, definitive reference work is written by an international team of acknowledged experts in the field. The authors explore the effective use of coordinated antimicrobial interventions to change prescribing practice and help slow the emergence of antimicrobial resistance, ensuring that antimicrobials remain an effective treatment for infection. Amongst the first of its kind, this book provides infectious disease physicians, administrators, laboratory, pharmacy, nursing and medical staff with practical guidance in setting up antimicrobial stewardship programs in their institutions with the aim of selecting the optimal antimicrobial drug regimen, dose, duration of therapy, and route of administration.

How to Overcome the Antibiotic Crisis

How to Overcome the Antibiotic Crisis
Author: Marc Stadler
Publisher: Springer
Total Pages: 497
Release: 2016-12-21
Genre: Medical
ISBN: 3319492845

This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the “bad bugs” are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.

Antibiotic Discovery and Development

Antibiotic Discovery and Development
Author: Thomas J. Dougherty
Publisher: Springer Science & Business Media
Total Pages: 1119
Release: 2011-12-18
Genre: Medical
ISBN: 1461414008

This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Perspectives in Biotechnology and Applied Microbiology

Perspectives in Biotechnology and Applied Microbiology
Author: Daham I. Alani
Publisher: Springer Science & Business Media
Total Pages: 376
Release: 2012-12-06
Genre: Science
ISBN: 9400943210

Upon an invitation from Arab Bureau of Education for the Gulf States "ABEGS"; an International Conference on Biotechnology and Applied Microbiol ogy was held in Riyadh, Saudi Arabia, 12-15 November 1984. The Conference was sponsored by ABEGS and organized through coopera tion with Saudi Biological Society "SBS". ABEGS was established in 1976 with the aim of coordinating, unifying and developing all aspects of Education, Culture and Science in the Gulf States. In the field of publications, ABEGS is publishing various books, pamphlets and two scientific journals, one in Arabic and the other in English entitled: the Arab Gulf Journal of Scientific Research. This volume contains topics presented by the invited speakers and selected papers from among those submitted by participants. Selection was done on basis of some of the invited talks. Main topics of the conference were grouped into sections representing seven themes of Biotechnology and Applied Microbiology: - production of microbial proteins - utilization of microorganisms for the production of chemicals - microbial treatment and utilization of waste - continuous culture - application of biotechnology in plant science - applied microbiology and environment and - applied microbiology and biotechnology: international cooperation - tween developed and developing countries. Some of the topics in this volume present surveys of recent developments in several important areas of biotechnology and applied microbiology, while the remaining papers carry detailed research contributions.

Nanostructures for Antimicrobial Therapy

Nanostructures for Antimicrobial Therapy
Author: Anton Ficai
Publisher: Elsevier
Total Pages: 724
Release: 2017-05-29
Genre: Science
ISBN: 0323461514

Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. - Shows how nanoantibiotics can be used to more effectively treat disease - Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs - Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area