Analysis With Supercritical Fluids Extraction And Chromatography
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| Author | : Bernd Wenclawiak |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 225 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 3642774741 |
The use of supercritical fluids in analytical chemistry is still grow ing. More and more analysts are discovering the favorable advan tages for a number of applications. Especially supercritical fluid extraction (SFE) has attracted a lot of interest in recent years due to its simplicity. Supercritical fluid chromatography (SFC) has become better established and the development of this technique has been accelerated by the many applications with capillary col umns which have been published in the literature. At first SFC equipment was based on instruments commonly used for liquid chromatography, and the first commercial in struments were derived from this technology. However, capillary columns can be much more easily interfaced to gas chromatogra phy equipment especially to the detectors commonly used for Oc. Many stationary phases both for packed micro columns and capillary columns have been designed for SFC purposes extending this technology to LC and OC. The most common fluid applied in SFC and SFE is carbon dioxide. The advantages of supercritical CO , such as having dif 2 fusivity like a gas and solvating power depending on temperature and pressure, are also valid for other fluids and modified fluids. Both properties are valuable for sample extraction and extraction selectivity.
| Author | : S.A. Westwood |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 180 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 9401121648 |
by Professor D. E. Games, Mass Spectrometry Research Unit, University College of Swansea Sample preparation can be viewed as occupying a Cinderella role in analytical science. However, the quality of sample preparation plays a key role in high In the past decade, there has been quality analysis and deserves higher stature. considerable interest in the use of supercritical fluid extraction (SFE) as an alternative to conventional procedures for the preparation of samples for ana lysis. The driving force for this development is the need for automated, sim pler, faster, non-destructive and selective methods for extraction, preferably using non-toxic extraction media which are easily disposed of. Utilization of supercritical fluids for extraction fulfils these requirements because of their unique physical chemical properties and usually low toxicity. Selectivity can be achieved by suitable selection of pressure (density), temperature and modi fier conditions which enable solvating power to be varied. The high diffusivity of supercritical fluids provides rapid sample penetration and extraction. Use of fluids with low critical temperatures enables extraction to be conducted under mild thermal conditions ensuring that thermally labile compounds do not decompose. The technique can be used off-line, and the extracts analysed by appropriate techniques, or it can be used on-line, by coupling with a variety of chromatographic techniques. These can then, if necessary, be coupled fur ther with spectroscopic techniques, such as Fourier transform infrared, ultra violet or mass spectrometry, to provide specific identification or structural information.
| Author | : Larry M. Miller |
| Publisher | : John Wiley & Sons |
| Total Pages | : 416 |
| Release | : 2019-12-12 |
| Genre | : Science |
| ISBN | : 1118948394 |
Explains why modern supercritical fluid chromatography (SFC) is the leading "green" analytical and purification separations technology. Modern supercritical fluid chromatography (SFC) is the leading method used to analyze and purify chiral and achiral chemical compounds, many of which are pharmaceuticals, pharmaceutical candidates, and natural products including cannabis-related compounds. This book covers current SFC instrumentation as it relates to greater robustness, better reproducibility, and increased analytical sensitivity. Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing Mobile Phases covers the history, instrumentation, method development and applications of SFC. The authors provided readers with an overview of analytical and preparative SFC equipment, stationary phases, and mobile phase choices. Topics covered include: Milestones of Supercritical Fluid Chromatography; Physical Properties of Supercritical Fluids; Instrumentation for SFC; Detection in SFC; Achiral SFC Method Development; Chiral SFC Method Development; and Preparative Scale SFC. The book also includes highlights of modern applications of SFC in the final chapters—namely pharmaceuticals, consumer products, foods, polymers, petroleum-related mixtures, and cannabis—and discusses the future of SFC. Provides a clear explanation of the physical and chemical properties of supercritical fluids, which gives the reader a better understanding of the basis for improved performance in SFC compared to HPLC and GC Describes the advantages of SFC as a green alternative to HPLC and GC for the analysis of both polar, water-soluble, and non-polar analytes Details both achiral and chiral SFC method development, including modifiers, additives, the impact of temperature and pressure, and stationary phase choices Details why SFC is the premier modern preparative chromatographic technique used to purify components of mixtures for subsequent uses, both from performance and economic perspectives Covers numerous detectors, with an emphasis on SFC-MS, SFC-UV, and SFC-ELSD (evaporative light scattering detection) Describes the application of SFC to numerous high-value application areas Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing Mobile Phases will be of great interest to professionals, students, and professors involved in analytical, bioanalytical, separations science, medicinal, petroleum, and environmental chemistries. It will also appeal to pharmaceutical scientists, natural-product scientists, food and consumer-products scientists, chemical engineers, and managers in these areas.
| Author | : John R. Dean |
| Publisher | : Chapman & Hall |
| Total Pages | : 224 |
| Release | : 1993-01-01 |
| Genre | : Science |
| ISBN | : 9780751400571 |
the continued search for rapid, efficient and cost-effective means of analytical measurement has introduced supercritical fluids into the field of analytical chemistry. Two areas are common: supercritical fluid chromatography and supercritical fluid extraction. Both seek to exploit the unique properties of a gas at temperatures and pressures above the critical point. The most common supercritical fluid is carbon dioxide employed because of its low critical temperature (310C), inertness, purity, non-toxicity and cheapness.
| Author | : Gérard Rossé |
| Publisher | : De Gruyter Textbook |
| Total Pages | : 0 |
| Release | : 2019 |
| Genre | : Business & Economics |
| ISBN | : 9783110500752 |
Supercritical Fluid Chromatography is a comprehensive guide to this modern separation technology. The book examines the main principles of SFC, advantages and challenges in comparison with common liquid chromatography as well as capabilities on the
| Author | : Mark McHugh |
| Publisher | : Elsevier |
| Total Pages | : 523 |
| Release | : 2013-10-22 |
| Genre | : Technology & Engineering |
| ISBN | : 0080518176 |
Supercritical Fluid Extraction is a technique in which CO2 is used under extremely high pressure to separate solution (e.g., removing caffeine from coffee). Separations is basic to all process industries and supercritical fluid extraction is a specific type which is receiving a high level of attention. The book will combine basic fundamentals with industrial applications. The second edition has been expanded and updated and includes new chapters on chromatography and food processing. "...this is an excellent book which is both instructive and amusing to read. Its true value is neatly summarised in one of the closing sentences: 'We have supplied you with the guidelines and criteria which you can now apply when considering supercritical fluids for your own needs.'' - Chemistry in Britain, February 1995
| Author | : Bernd Wenclawiak |
| Publisher | : |
| Total Pages | : 232 |
| Release | : 1992-11-03 |
| Genre | : |
| ISBN | : 9783642774751 |
The editor has brought together in a compact and readable form the new methods of analytical chemistry using supercritical fluids. The volume provides comprehensive treatment of supercritical fluid chromatography (SFC) and supercritical fluid extraction (SFE); it discusses both theory and practice. The contributions are written by leading experts in their fields with exhaustive practical experience in SFC and SFE. Special attention is given to the description of applications and thus provides the experienced analyst with invaluable information widely scattered in the literature and helps the novice to adopt these new techniques quickly in his laboratory. An addendum includes brand new literature on SFC and SFE.
| Author | : Thomas Caudell |
| Publisher | : Routledge |
| Total Pages | : 450 |
| Release | : 2018-05-08 |
| Genre | : Science |
| ISBN | : 1351422502 |
An exploration of fundamental as well as practical aspects of supercritical fluid chromatography and extraction. It addresses topics such as: packed columns in SFC; detection in SFC; supercritical fluid chromatography/mass spectroscopy; and evaporative light scattering detection in SFC.
| Author | : Thomas Caudell |
| Publisher | : CRC Press |
| Total Pages | : 450 |
| Release | : 1999-03-08 |
| Genre | : Science |
| ISBN | : 9789057024092 |
This book explores the fundamental and practical aspects of supercritical fluid chromatography (SFC) and extraction. It discusses packed columns in SFC; detection in SFC; supercritical fluid chromatography/mass spectroscopy; and evaporative light scattering detection in SFC.
| Author | : E.D. Ramsey |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 449 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 9401149488 |
During the past decade supercritical fluid extration (SFE) has attracted considerable attention as a sample preparation procedure in analytical chemistry. The successful implementation of this technique can lead to improved sample throughput, more efficient recovery of analytes, cleaner extracts, economic replacement of halogenated solvents and a high level of automation, compared to conventional sample preparation procedures. This book provides an overview of basic principles of SFE as well as in-depth reviews of both on- and off-line SFE methods. The on-line coupling of SFE with both chromatographic and spectroscopics techniques has been the subject of a great deal of research effort and is dealt with in detail. Newer developments, such as off-line SFE of solid and liquid matrices, are starting to attract a great deal of interest, and the coverage of these areas will prove of particular value to the analytical chemist. The international team of authors has illustrated these topics with many `state-of-the-art' applications, and each chapter provides a comprehensive list of references. For the convenience of the reader, an appendix which contains pressure conversion scales and supercritical fluid carbon dioxide density tables appears at the end of the book. The volume's extensive coverage of both on-line and off-line extraction will be particularly useful to analytical chemists, in a wide range of environments, seeking to develop high quality, simple and robust SFE methods.
