Soil is not only a fundamental source for all living organisms but also impacts non-living factors (water, air, minerals, etc.) making it an invaluable and finite resource. The importance of soil expands from agronomy through to industrialization, thus, it is crucial to understand the impact of human activity on soil quality. To address several global issues related to pollution, food security, and health, the United Nations promotes the Sustainable Development Goals (SDGs) with targets to ‘save soil’ by minimizing nutrient loss and pollution load from the soil. Due to increasing anthropogenic pollution load, many soil pollution control measures are failing, therefore, new technologies and eco-friendly solutions are needed to balance and restore soil health. Soil-crop interactions are essential considering the crop yield and productivity under different soil statuses. These processes, including nutrient release or soi detoxification, are mediated by soil-inhabiting microbes. In fact, the intrinsic role of soil parameters, including the different classes of soil, control soil microbiota which in turn modulate soil nutrient contents and makes these bioavailable. Different crops, especially cereals, are constantly interacting with these soil microbes, thus the relationship between soil, crops, and microbes is complex.