HIV-1 Integrase

HIV-1 Integrase
Author: Nouri Neamati
Publisher: John Wiley & Sons
Total Pages: 710
Release: 2011-08-10
Genre: Science
ISBN: 1118015363

This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.

Handbook of Antimicrobial Resistance

Handbook of Antimicrobial Resistance
Author: Matthias Gotte
Publisher: Springer
Total Pages: 0
Release: 2018-02-12
Genre: Medical
ISBN: 9781493906932

While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.

Introduction to Clinical Infectious Diseases

Introduction to Clinical Infectious Diseases
Author: Joseph Domachowske
Publisher: Springer
Total Pages: 465
Release: 2019-02-14
Genre: Medical
ISBN: 3319910809

Infectious diseases as a specialty suffers from many unique challenges stemming from lower salaries compared to other medical specialties and difficulty keeping the younger demographic within the field. With emerging infections, new diagnostic and research tools, and changing migration patterns, these problems are amplified; infectious disease specialists are in higher demand than ever with fewer and fewer specialists available to support patients and colleagues outside of the field. To meet these increasing challenges, it is vital for the workforce of the future to have the best training possible. This book aims to provide this support. As trainees, all physicians face clinical infectious disease scenarios on a daily basis. They receive basic training in common infections, giving them the tools needed for initial diagnostic studies and empiric treatment. This approach, however, still leaves them struggling with nuances of treating common infections, infections that masquerade as other diseases, rare infection, advanced diagnostics, complicating medical conditions, and a wide range of medical complexities. Important clinical microbiology details and host susceptibility risks will be highlighted when discussing uncommon infections. Each chapter begins by defining a distinct clinical infectious disease problem and the most common cause(s). The next section of each chapter identifies the key questions to consider, including other possible pathogens, medical history, alternate microbiologic diagnoses, instances of unexpected result. This book is the only academic text designed specifically to meet this challenge by targeting learners at all levels. To do this, the text incorporate 30-40 common clinical infectious disease scenarios in both adult and pediatric hosts. It includes easy-to-access “tips and tricks” for when to look further or consider possibilities that are unusual that is useful for someone who is new to the information or has limited experience within infectious diseases. The text heavily features teaching and learning tools, including call out boxes that prioritizes infectious etiologies, host risk factors, important microbiologic clues, and important clinical history clues. The text also includes review questions and quiz-like challenges to reinforce the concepts. Written by experts in the field Clinical Infectious Diseases is the most cutting-edge academic resource for all medical students, fellows, residents, and trainees, including infectious disease specialists in both adult and pediatric care, internal medicine specialists, and hospitalists.

Structural Biology in Drug Discovery

Structural Biology in Drug Discovery
Author: Jean-Paul Renaud
Publisher: John Wiley & Sons
Total Pages: 1437
Release: 2020-01-09
Genre: Medical
ISBN: 1118900502

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Disease Control Priorities, Third Edition (Volume 6)

Disease Control Priorities, Third Edition (Volume 6)
Author: King K. Holmes
Publisher: World Bank Publications
Total Pages: 1027
Release: 2017-11-06
Genre: Medical
ISBN: 1464805253

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Antiviral Drug Resistance

Antiviral Drug Resistance
Author: Douglas D. Richman
Publisher: Wiley
Total Pages: 324
Release: 1996-12-02
Genre: Medical
ISBN: 9780471961208

The study of antiviral drug resistance has provided important insights into the structure of virus enzymes, the functions of certain genes, mechanisms of action of antiviral drugs, the design of new antiviral compounds and the pathogenesis of viral diseases. The emergence of resistant strains must be explored at all stages of drug development: during the preclinical evaluation of candidate compounds; during the early clinical evaluation of new drugs; and as part of epidemiological surveillance for the prevalence of resistance during use of approved treatments. Accumulating understanding of antiviral drug resistance thus reflects progress in the chemotherapy of viral infection. Antiviral Drug Resistance provides state-of-the-art coverage of the basic and clinical aspects of this subject. It deals with the basic science, including the mechanisms of drug resistance and drug action, genetics of drug resistance, cross resistance, and X-ray crystallographic structural aspects of resistance, as well as the clinical aspects, including issues of assay of susceptibility of clinical isolates, descriptive aspects of emergence of reduced susceptibility, and clinical significance and impact of resistance. As such this unique volume will be essential to basic researchers in drug discovery and viral pathogenesis, as well as clinicians involved in antiviral chemotherapy.

HIV and Disability

HIV and Disability
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 217
Release: 2010-11-17
Genre: Medical
ISBN: 030917712X

The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus qualify for disability benefits. In this report, the Institute of Medicine (IOM) makes several recommendations for improving SSA's capacity for determining disability benefits more accurately and quickly using the HIV Infection Listings.

Virus Dynamics : Mathematical Principles of Immunology and Virology

Virus Dynamics : Mathematical Principles of Immunology and Virology
Author: Martin Nowak
Publisher: Oxford University Press, UK
Total Pages: 253
Release: 2000-11-23
Genre:
ISBN: 0191588512

This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature

HIV-1 Latency

HIV-1 Latency
Author: Guido Silvestri
Publisher: Springer
Total Pages: 253
Release: 2018-10-11
Genre: Medical
ISBN: 303002816X

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

Molecular Interaction Fields

Molecular Interaction Fields
Author: Gabriele Cruciani
Publisher: John Wiley & Sons
Total Pages: 328
Release: 2006-05-12
Genre: Science
ISBN: 3527607137

This unique reference source, edited by the world's most respected expert on molecular interaction field software, covers all relevant principles of the GRID force field and its applications in medicinal chemistry. Entire chapters on 3D-QSAR, pharmacophore searches, docking studies, metabolism predictions and protein selectivity studies, among others, offer a concise overview of this emerging field. As an added bonus, this handbook includes a CD-ROM with the latest commercial versions of the GRID program and related software.