Advances In Drug Research
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Author | : Ernst Jucker |
Publisher | : Springer Science & Business Media |
Total Pages | : 316 |
Release | : 2001 |
Genre | : Medical |
ISBN | : 9783764362669 |
Progress in Drug Research is a prestigious book series which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmacological research. It serves as an important source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.
Author | : Bernard Testa |
Publisher | : |
Total Pages | : 368 |
Release | : 1985 |
Genre | : |
ISBN | : 9780120133147 |
Author | : Bernard Testa |
Publisher | : Elsevier |
Total Pages | : 312 |
Release | : 2013-10-22 |
Genre | : Medical |
ISBN | : 1483266885 |
Advances in Drug Research, Volume 21 comprises three chapters that deal with the general subject, specific therapeutic class, and chemical family of diverse drugs. The first chapter of this book discusses the absorption and distribution of drugs in the lymphatic system. A presentation of the anti-infective quinolones is provided in Chapter 2, while the design and therapeutic potential of peptides are elaborated in Chapter 3. Other topics covered include lymphotropic carriers and the lymph uptake mechanism; basis of circulation in lymphatic transport of molecules through various routes of administration; and general aspects and characteristics of quinolone antibacterial agents. The mode of action and mechanisms of resistance of quinolones; potent agonists and antagonists of peptides; and inhibitors of atrial natriuretic factor-degrading enzymes are also deliberated in this text. This publication is valuable to drug researchers and students interested in advances in drugs.
Author | : Harper, N.J., (ed.) |
Publisher | : |
Total Pages | : 278 |
Release | : 1970 |
Genre | : |
ISBN | : |
Author | : N... J... Harper |
Publisher | : |
Total Pages | : 356 |
Release | : 1977 |
Genre | : MEDICAL |
ISBN | : 9780120133123 |
Author | : N. J. Harper |
Publisher | : |
Total Pages | : |
Release | : 1964 |
Genre | : Pharmacology |
ISBN | : |
Author | : N. J. Harper |
Publisher | : Elsevier |
Total Pages | : 365 |
Release | : 2013-10-22 |
Genre | : Medical |
ISBN | : 148321513X |
Advances in Drug Research, Volume 12 covers articles on advances in drug research. The book presents articles on cyclic nucleotides as targets for drug design; the opposing regulatory roles of cyclic nucleotides in the heart; and the integrated control of trematode diseases. The text also includes articles about the chemical and biological studies on indomethacin, sulindac and their analogs; as well as the pharmacokinetics, pharmacodynamics, toxicity, and the effects of bromocriptine. Toxicologists, pharmacologists, physicians, and drug researchers will find the book invaluable.
Author | : Bijoy Kundu |
Publisher | : Birkhäuser |
Total Pages | : 276 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3034887302 |
Author | : Bernard Testa |
Publisher | : |
Total Pages | : 0 |
Release | : 1986 |
Genre | : |
ISBN | : |
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 107 |
Release | : 2014-02-06 |
Genre | : Medical |
ISBN | : 0309292492 |
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.