History of the Synapse

History of the Synapse
Author: Max R. Bennett
Publisher: CRC Press
Total Pages: 351
Release: 2003-09-02
Genre: Science
ISBN: 0203302540

The History of the Synapse provides a history of those discoveries concerning the identification and function of synapses that provide the foundations for research during this new century with a personal view of the process by which new concepts have developed. Previously published as essays, the chapters in this book provide a history of various aspects of synaptic function, beginning with the evolution over two and a half thousand years and how progress was made in the establishment of a conceptual structure that would allow the synapse to be identified at the beginning of the 20th century. Numerous illustrations explain either the technical approach or the experimental finding.

From Neurons to Neighborhoods

From Neurons to Neighborhoods
Author: National Research Council
Publisher: National Academies Press
Total Pages: 610
Release: 2000-11-13
Genre: Social Science
ISBN: 0309069882

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Brain Architecture : Understanding the Basic Plan

Brain Architecture : Understanding the Basic Plan
Author: and Director NIBS Neuroscience Program University of Southern California Larry W. Swanson Milo Don and Lucille Appleman Professor of Biological Sciences
Publisher: Oxford University Press, USA
Total Pages: 283
Release: 2002-10-23
Genre: Medical
ISBN: 0198026463

Depending on your point of view the brain is an organ, a machine, a biological computer, or simply the most important component of the nervous system. How does it work as a whole? What are its major parts and how are they interconnected to generate thinking, feelings, and behavior? This book surveys 2,500 years of scientific thinking about these profoundly important questions from the perspective of fundamental architectural principles, and then proposes a new model for the basic plan of neural systems organization based on an explosion of structural data emerging from the neuroanatomy revolution of the 1970's. The importance of a balance between theoretical and experimental morphology is stressed throughout the book. Great advances in understanding the brain's basic plan have come especially from two traditional lines of biological thought-- evolution and embryology, because each begins with the simple and progresses to the more complex. Understanding the organization of brain circuits, which contain thousands of links or pathways, is much more difficult. It is argued here that a four-system network model can explain the structure-function organization of the brain. Possible relationships between neural networks and gene networks revealed by the human genome project are explored in the final chapter. The book is written in clear and sparkling prose, and it is profusely illustrated. It is designed to be read by anyone with an interest in the basic organization of the brain, from neuroscience to philosophy to computer science to molecular biology. It is suitable for use in neuroscience core courses because it presents basic principles of the structure of the nervous system in a systematic way.

Neuroproteomics

Neuroproteomics
Author: Oscar Alzate
Publisher: CRC Press
Total Pages: 356
Release: 2009-10-26
Genre: Medical
ISBN: 1420076264

In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg

Anesthetic Pharmacology

Anesthetic Pharmacology
Author: Alex S. Evers
Publisher: Cambridge University Press
Total Pages: 2902
Release: 2011-03-10
Genre: Medical
ISBN: 1139497022

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Botulinum Neurotoxins

Botulinum Neurotoxins
Author: Andreas Rummel
Publisher: Springer
Total Pages: 0
Release: 2015-01-29
Genre: Medical
ISBN: 9783642448898

The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

A History of the Brain

A History of the Brain
Author: Andrew P. Wickens
Publisher: Psychology Press
Total Pages: 405
Release: 2014-12-08
Genre: Psychology
ISBN: 1317744837

A History of the Brain tells the full story of neuroscience, from antiquity to the present day. It describes how we have come to understand the biological nature of the brain, beginning in prehistoric times, and progressing to the twentieth century with the development of Modern Neuroscience. This is the first time a history of the brain has been written in a narrative way, emphasizing how our understanding of the brain and nervous system has developed over time, with the development of the disciplines of anatomy, pharmacology, physiology, psychology and neurosurgery. The book covers: beliefs about the brain in ancient Egypt, Greece and Rome the Medieval period, Renaissance and Enlightenment the nineteenth century the most important advances in the twentieth century and future directions in neuroscience. The discoveries leading to the development of modern neuroscience gave rise to one of the most exciting and fascinating stories in the whole of science. Written for readers with no prior knowledge of the brain or history, the book will delight students, and will also be of great interest to researchers and lecturers with an interest in understanding how we have arrived at our present knowledge of the brain.