A Genetic Switch
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Author | : Mark Ptashne |
Publisher | : CSHL Press |
Total Pages | : 172 |
Release | : 2004 |
Genre | : Medical |
ISBN | : 9780879697167 |
The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long-range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.
Author | : Mark Ptashne |
Publisher | : CSHL Press |
Total Pages | : 212 |
Release | : 2002 |
Genre | : Medical |
ISBN | : 9780879696337 |
Author | : Mark Ptashne |
Publisher | : Wiley-Blackwell |
Total Pages | : 128 |
Release | : 1986 |
Genre | : Science |
ISBN | : 9780865423152 |
Author | : Bruce Alberts |
Publisher | : |
Total Pages | : 0 |
Release | : 2002 |
Genre | : Cytology |
ISBN | : 9780815332183 |
Author | : Benno Müller-Hill |
Publisher | : Walter de Gruyter |
Total Pages | : 221 |
Release | : 2011-05-12 |
Genre | : Science |
ISBN | : 3110879476 |
Author | : M. Ptashne |
Publisher | : |
Total Pages | : |
Release | : 1987 |
Genre | : |
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Author | : Nessa Carey |
Publisher | : Columbia University Press |
Total Pages | : 353 |
Release | : 2012-03-06 |
Genre | : Science |
ISBN | : 0231530714 |
Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.
Author | : Mark Ptashne |
Publisher | : |
Total Pages | : 154 |
Release | : 2004 |
Genre | : Bacteriophage lambda |
ISBN | : 9787506259729 |
Author | : Rob Phillips |
Publisher | : Princeton University Press |
Total Pages | : 436 |
Release | : 2020-09 |
Genre | : Science |
ISBN | : 0691200246 |
A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena. Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons. Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.
Author | : M. Ptashne |
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