Zinc Metalloproteases In Health And Disease
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Author | : NM Hooper |
Publisher | : CRC Press |
Total Pages | : 357 |
Release | : 1996-07-30 |
Genre | : Medical |
ISBN | : 1482272768 |
The zinc metalloproteases are a diverse group of enzymes which are becoming increasingly important in a variety of biological systems. Their major function is to break down proteins. This text presents recent research results on the biochemistry and molecular biology of these enzymes.
Author | : Lawrence T. Fairhall |
Publisher | : |
Total Pages | : 0 |
Release | : |
Genre | : |
ISBN | : |
Author | : George J. Brewer |
Publisher | : |
Total Pages | : 365 |
Release | : 1977 |
Genre | : Sickle cell anemia |
ISBN | : 9780845100141 |
Author | : George J. Brewer |
Publisher | : |
Total Pages | : 30 |
Release | : 1977 |
Genre | : |
ISBN | : |
Author | : Bert L. Vallee |
Publisher | : |
Total Pages | : 24 |
Release | : 1971 |
Genre | : Zinc |
ISBN | : |
Author | : J. F. Woessner |
Publisher | : |
Total Pages | : 0 |
Release | : 2023 |
Genre | : Extracellular matrix proteins |
ISBN | : 9781383020427 |
This study covers the sequence information, three-dimensional structures, activation, protein substrates, specificity requirements, inhibition, and biological roles of identified MMPs.
Author | : Nikos Karamanos |
Publisher | : Walter de Gruyter |
Total Pages | : 940 |
Release | : 2012-08-31 |
Genre | : Science |
ISBN | : 3110258773 |
Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick HeinegÄrd, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden
Author | : K. D. Rainsford |
Publisher | : Springer Science & Business Media |
Total Pages | : 218 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9401139636 |
Abnormal metabolism and distribution of both copper and zinc occurs in many inflammatory and degenerative diseases. The pattern of these changes varies at different stages of these diseases and with differing types of conditions. The corollary to this situation is the possibility of using drugs or metal complexes to modify both the perturbed status of copper and zinc and thus the disease states. This book comprehensively reviews the clinical and experimental data on the changes in copper and zinc status in different diseases and the use of various complexes of these metals or drugs to treat a diversity of inflammatory and degenerative conditions.
Author | : Shaul Massry |
Publisher | : Springer Science & Business Media |
Total Pages | : 611 |
Release | : 2013-11-21 |
Genre | : Medical |
ISBN | : 1461342171 |
We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.
Author | : Neil J. Clendeninn |
Publisher | : Springer Science & Business Media |
Total Pages | : 371 |
Release | : 2000-09-17 |
Genre | : Medical |
ISBN | : 159259011X |
Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metalloproteinase Inhibitors in Cancer Therapy offers basic and clinical investigators alike a richly informative summary of all the latest research on these powerful new drugs, and their high promise as emerging cancer therapeutics.