Zebrafish Research - An Ever-Expanding Experimental Model

Zebrafish Research - An Ever-Expanding Experimental Model
Author: Geonildo Rodrigo Disner
Publisher: BoD – Books on Demand
Total Pages: 156
Release: 2024-05-22
Genre: Science
ISBN: 0854663509

The Danio rerio (zebrafish) is an alternative vertebrate animal model for in vitro and in vivo research methodologies. In the last decades, notably due to increased laboratory investigation, novel discoveries, and complete genome sequencing, the zebrafish has attracted great interest from the scientific community. Its exceptional genetic homology to humans and the large number of mutations and diseases that can be reproduced in the make zebrafish an effective research model. This book examines the advantages of using zebrafish in scientific applications.

Vascular Development

Vascular Development
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
Total Pages: 260
Release: 2007-08-20
Genre: Science
ISBN: 0470319429

The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.

Perspectives in Zebrafish Research

Perspectives in Zebrafish Research
Author: Maria Caterina Mione
Publisher: Frontiers Media SA
Total Pages: 142
Release: 2020-04-22
Genre:
ISBN: 2889636690

In the past decade, a small tropical vertebrate fish, zebrafish, has rapidly gained the interest of research laboratories worldwide as a model system. This topic will provide updated perspectives on all fields of zebrafish research from experts gathering at the 5th Zebrafish Principal Investigators Meeting in Trento, 20-23 March 2018. The community of researchers using zebrafish is rapidly expanding, necessitating a clear plan for how to tackle central questions that remain a challenge in the field and providing inspiration for future studies. This is the aim of the workshop and the Frontiers Research Topic will provide a platform for dissemination of novel ideas arising from this meeting.

Zebrafish Models in Neurobehavioral Research

Zebrafish Models in Neurobehavioral Research
Author: Allan V. Kalueff
Publisher: Humana Press
Total Pages: 298
Release: 2016-08-23
Genre: Medical
ISBN: 9781493959228

Animal models have traditionally played a crucial role in improving our understanding of brain pathogenesis. Zebrafish (Danio rerio) have generated considerable discoveries in the areas of genetics, embryology, endocrinology, and neuroscience. Zebrafish Models in Neurobehavioral Research emphasizes the growing importance of zebrafish in neurobehavioral research and portrays an extensive, thorough perspective on the emergence of zebrafish as robust and translational models. Written by leading international experts, the book covers major topics ranging from stress to learned recognition of environment, encompassing a wide spectrum of the utility of zebrafish within neurobiological disciplines. The chapters provide authoritative reviews of many zebrafish paradigms commonly used in the field today. This book will be a useful guide for zebrafish researchers, and will complement another related book from the popular Neuromethods series, Zebrafish Neurobehavioral Protocols. Comprehensive and up-to-date, Zebrafish Models in Neurobehavioral Research serves as an ideal resource for scientists new to the field as well as for established researchers seeking valuable insight into the growing utility of zebrafish in neuroscience.

Laboratory Fish in Biomedical Research

Laboratory Fish in Biomedical Research
Author: Livia D'Angelo
Publisher: Academic Press
Total Pages: 476
Release: 2021-08-28
Genre: Science
ISBN: 0128212454

Fish, and particularly zebrafish, have become the fastest-growing segment of the research population. They offer several advantages, in terms of biology and technologies to apply, and thus are employed in numerous research fields. Laboratory Fish in Biomedical Research: Biology, Husbandry and Research Applications for Zebrafish, Medaka, Killifish, Swordtail Fish, Cavefish, Stickleback, Goldfish and Danionella Translucida addresses the relevant and increasing need to collect cutting-edge knowledge on husbandry, maintenance, welfare and experimental protocols of the most common freshwater species under standard laboratory conditions. Provides husbandry and management protocols, devices and water systems Shows strength and weakness of breeding Explores potential scientific applications and experimental protocols. with regards to the most used freshwater fish used for scientific purposes

Zebrafish

Zebrafish
Author: Graham J. Lieschke
Publisher: Humana Press
Total Pages: 335
Release: 2009-05-15
Genre: Science
ISBN: 9781603279765

In the last 20 years, research activity using the zebrafish Danio rerio has increased dramatically, due in part to the ease of breeding and raising them, their genetic tractability, embryonic accessibility, and their imaging potential. In Zebrafish: Methods and Protocols, expert researchers provide a collection of experimental techniques for the genetic modification, manipulation, and in vivo live imaging of zebrafish. This volume collects sophisticated and practical techniques, including several not yet widely known, from laboratories around the world. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Zebrafish: Methods and Protocols seeks to aid and inspire scientists utilizing this versatile animal model in their research.

The Laboratory Zebrafish

The Laboratory Zebrafish
Author: Claudia Harper
Publisher: CRC Press
Total Pages: 260
Release: 2016-04-19
Genre: Medical
ISBN: 1439807442

Like other books in the Laboratory Animal Pocket Reference Series, this guide covers all aspects pertaining to the use of these organisms including their basic biology, humane care and management, husbandry, life support systems, regulatory compliance, technical procedures, veterinary care, and water quality management. In the relatively brief span

Zebrafish Model for Biomedical Research

Zebrafish Model for Biomedical Research
Author: Prasan R. Bhandari
Publisher: Springer Nature
Total Pages: 493
Release: 2022-05-30
Genre: Medical
ISBN: 9811652171

This book provides the latest information on the significance of zebrafish as an ideal model for researching the biomedical field, with references. This book also focused on the evidence of zebrafish as a model in cardiovascular, neurologic, psychiatric and metabolic research. In addition, the book also includes the research carried out on zebrafish in hepatic, renal, ophthalmic, and ENT related areas. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish models including specific research in the area of skin disorders, endocrine diseases, nutritional disorders, gastrointestinal, hematological disorders and cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and its suitability for modeling various diseases, providing a critical resource on the potential attributes of the zebrafish as a pharmacological model. In terms of scope, this book is a useful tool for young researchers, professors and pharmaceutical scientists for understanding the significance of zebrafish as an emerging pharmacological model that can significantly aid in the process of drug discovery and development.

Zebrafish Neurobehavioral Protocols

Zebrafish Neurobehavioral Protocols
Author: Allan V. Kalueff
Publisher: Humana Press
Total Pages: 206
Release: 2011-04-06
Genre: Medical
ISBN: 9781607619543

As a model organism, zebrafish (Danio rerio) offer an opportunity to perform steadfast scientific investigations in a robust and high-throughput manner. In Zebrafish Neurobehavioral Protocols, experts in the field provide a series of detailed behavioral protocols dealing with the major current research areas in the field of behavioral neuroscience. The chapters discuss the use and interpretation of video-aided quantification of zebrafish behaviors, describe novel assays commonly used to quantify emotionality, learning, memory, and social behaviors in zebrafish, and instruct how to quantify endocrine responses and correlate them with behavior. Written in the Neuromethods series format, the chapters provide authoritative reviews of many commonly used approaches in the field today. This "how to" book will be a useful practical guide for zebrafish researchers and will complement another related book from this series, Zebrafish Models in Neurobehavioral Research. Cutting-edge and timely, Zebrafish Neurobehavioral Protocols serves as an excellent compilation epitomizing the growing potential of zebrafish in modern scientific inquiry.