Zebrafish at the Interface of Development and Disease Research

Zebrafish at the Interface of Development and Disease Research
Author:
Publisher: Academic Press
Total Pages: 386
Release: 2017-03-21
Genre: Medical
ISBN: 0128033436

Zebrafish at the Interface of Development and Disease Research presents the latest on the shared pathways that govern development and contribute to disease. Zebrafish have traditionally been used to study vertebrate development, providing interesting data on the developmental processes and genes that are implicated in disease. This new release in the series contains informative discussions on congenital heart defects in zebrafish, the use of zebrafish in studying kidney development and disease, and muscle development, homeostasis and disease in zebrafish. Each chapter interweaves the study of zebrafish development and its application to the immune system, the kidney, liver, heart and others. - The subject matter is unique - no single volume has pulled together the theme of development and disease with zebrafish as a centerpiece - Leading experts in the field - all of them running zebrafish focused labs for each chapter

The Zebrafish in Biomedical Research

The Zebrafish in Biomedical Research
Author: Samuel Cartner
Publisher: Academic Press
Total Pages: 720
Release: 2019-11-22
Genre: Science
ISBN: 0128124326

The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. - Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications - Includes the work of world-renowned authors - Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series

Vascular Development

Vascular Development
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
Total Pages: 260
Release: 2007-08-20
Genre: Science
ISBN: 0470319429

The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.

Kidney Development and Disease

Kidney Development and Disease
Author: Rachel K. Miller
Publisher: Springer
Total Pages: 373
Release: 2017-04-13
Genre: Science
ISBN: 3319514369

Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.

The Zebrafish: Cellular and Developmental Biology, Part B

The Zebrafish: Cellular and Developmental Biology, Part B
Author:
Publisher: Academic Press
Total Pages: 317
Release: 2011-06-02
Genre: Technology & Engineering
ISBN: 0123870372

This volume of Methods in Cell Biology, the second of two parts on the subject of zebrafish, provides a comprehensive compendium of laboratory protocols and reviews covering all the new methods developed since 1999. - Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls - Illustrates many techiques in full-color - Summarizes the Zebrafish Genome Project

The Zebrafish

The Zebrafish
Author: Joseph A. Holden
Publisher: Cambridge University Press
Total Pages: 157
Release: 2013-01-21
Genre: Science
ISBN: 1139620630

The zebrafish (Danio rerio) is a valuable and common model for researchers working in the fields of genetics, oncology and developmental sciences. This full-color atlas will aid experimental design and interpretation in these areas by providing a fundamental understanding of zebrafish anatomy. Over 150 photomicrographs are included and can be used for direct comparison with histological slides, allowing quick and accurate identification of the anatomic structures of interest. Hematoxylin and eosin stained longitudinal and transverse sections demonstrate gross anatomic relationships and illustrate the microscopic anatomy of major organs. Unlike much of the current literature, this book is focused exclusively on the zebrafish, eliminating the need for researchers to exclude structures that are only found in other fish.

Microsporidia

Microsporidia
Author: Louis M. Weiss
Publisher: John Wiley & Sons
Total Pages: 756
Release: 2014-07-25
Genre: Science
ISBN: 1118395239

Microsporidia: Pathogens of Opportunity provides a systematic overview of the biology of microsporidia. Written by leading experts in the field, the book combines background and basic information on microsporidia with descriptive methods and resources for working with the pathogen. Newly revised and updated for its second edition, Microsporidia will continue to be the standard text reference for these pathogenic protists, and is an indispensable research resource for biologists, physicians and parasitologists. This new edition of this publication provides systematic reviews of the biology of this pathogen by leading experts in the field, and will be combined with descriptions of the methods and resources for working with this pathogen. • Provides a comprehensive summary of literature on microsporidia and microsporidiosis • The long-awaited update to the standard microsporidia reference text The Microsporidia and Microsporidiosis • Written by an international team of authors representing each of the main research groups working on microsporidia • Chapters provide comprehensive overviews of general methodology as well as special techniques related to these organisms

Gene Drives on the Horizon

Gene Drives on the Horizon
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 231
Release: 2016-08-28
Genre: Science
ISBN: 0309437873

Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.