The Jesus Prayer is a form of prayer that for centuries has been preserved and practiced by the Hesychasm, the eremitic tradition that is the direct inheritor of the Desert Fathers of early Christianity. Such prayer is deeply similar to the Integral Yoga spiritual practice or sadhana. Both traditions have a comparable understanding of the human being and both bestow a special role to the heart as the place for integration and purification of the psyche as well as of gnosis and union with the Divine. This dissertation proposes the term heart-soul axis to study the structural, functional, and phenomenological aspects of the heart. The main methodological tools are hermeneutics and the geometrical model or topological invariant of Panikkar to stablish homeomorphic equivalences enabling a valid integration of both traditions. In addition, the dissertation offers an autoethnographical narrative in which the heuristic process leading to a creative visual synthesis is disclosed.