Neurodegenerative Diseases

Neurodegenerative Diseases
Author: G. Jolles
Publisher: Academic Press
Total Pages: 330
Release: 1994-11-14
Genre: Medical
ISBN:

Over the last few years, the considerable progress made in biochemistry, virology, molecular biology and genetics has revealed some of the intimate mechanisms of the neurodegenerative diseases. The present volume is an attempt to review the latest data in the field to illuminate new avenues for future research. This volume gathers together chapters and discussions on the etiology and pathogenesis of the neurodegenerative diseases. Apoptosis of programmed cell death as well as other genetic implications are discussed; special attention is given to the coexistence and interconnection of genetic and environmental factors. There is extensive coverage of prions responsible for bovine spongiform encephalopathy, Cruetzfeld-Jacob disease and kuru. The various aspects of non-conventional transmissible agents are thoroughly reviewed. Further contributions deal with the role of growth factors as well as of free radicals. Consideration is given to the molecular mechanisms of Alzheimer's disease, in particular the role of tau protein. Finally, several pharmacological models now available, which throw light upon aspects of Parkinson's disease, Huntington's chorea and multiple sclerosis, are examined and discussed. It is hoped that recent scientific advances will lead to the discovery of new drugs to fill the current therapeutic void. There are hopes of an early indication of this in the case of amyotrophic lateral sclerosis.

Smoking and Health

Smoking and Health
Author: United States. Surgeon General's Advisory Committee on Smoking and Health
Publisher:
Total Pages: 406
Release: 1964
Genre: Smoking
ISBN:

World Cities Report 2020

World Cities Report 2020
Author: United Nations
Publisher:
Total Pages: 416
Release: 2020-11-30
Genre:
ISBN: 9789211328721

In a rapidly urbanizing and globalized world, cities have been the epicentres of COVID-19 (coronavirus). The virus has spread to virtually all parts of the world; first, among globally connected cities, then through community transmission and from the city to the countryside. This report shows that the intrinsic value of sustainable urbanization can and should be harnessed for the wellbeing of all. It provides evidence and policy analysis of the value of urbanization from an economic, social and environmental perspective. It also explores the role of innovation and technology, local governments, targeted investments and the effective implementation of the New Urban Agenda in fostering the value of sustainable urbanization.

Drug Transporters

Drug Transporters
Author: Martin F. Fromm
Publisher: Springer Science & Business Media
Total Pages: 457
Release: 2010-11-19
Genre: Medical
ISBN: 3642145418

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Update '98

Update '98
Author:
Publisher:
Total Pages: 592
Release: 1998
Genre: Export controls
ISBN:

Towards Sustainable Society on Ubiquitous Networks

Towards Sustainable Society on Ubiquitous Networks
Author: Makoto Oya
Publisher: Springer Science & Business Media
Total Pages: 378
Release: 2008-09-02
Genre: Computers
ISBN: 0387856900

The massive growth of the Internet has made an enormous amount of infor- tion available to us. However, it is becoming very difficult for users to acquire an - plicable one. Therefore, some techniques such as information filtering have been - troduced to address this issue. Recommender systems filter information that is useful to a user from a large amount of information. Many e-commerce sites use rec- mender systems to filter specific information that users want out of an overload of - formation [2]. For example, Amazon. com is a good example of the success of - commender systems [1]. Over the past several years, a considerable amount of research has been conducted on recommendation systems. In general, the usefulness of the recommendation is measured based on its accuracy [3]. Although a high - commendation accuracy can indicate a user's favorite items, there is a fault in that - ly similar items will be recommended. Several studies have reported that users might not be satisfied with a recommendation even though it exhibits high recommendation accuracy [4]. For this reason, we consider that a recommendation having only accuracy is - satisfactory. The serendipity of a recommendation is an important element when c- sidering a user's long-term profits. A recommendation that brings serendipity to users would solve the problem of “user weariness” and would lead to exploitation of users' tastes. The viewpoint of the diversity of the recommendation as well as its accuracy should be required for future recommender systems.