Self-care interventions, including for sexual and reproductive health and rights, are among the most promising new approaches to improving health and well-being, both from a health systems perspective and for the users of these interventions. Self-care interventions should be an adjunct to, rather than a replacement for, direct interaction with the health system. These interventions are increasingly being acknowledged in global initiatives, including to advance primary health care (PHC) and universal health coverage (UHC). When they are accessible, available, acceptable, and affordable, quality self-care interventions hold the promise of advancing the attainment of UHC. Building upon the latest WHO recommendations and good practice statements, this implementation guidance includes key considerations to support the introduction and scale-up of self-care interventions in countries. In implementing the global recommendations on self-care interventions for health and well-being, countries will need to adapt them to the local context, considering the economic conditions and the existing health services and facilities. This guidance is intended to assist with that process and requires interaction with all health systems building blocks to ultimately improve national health systems in terms of efficiency, responsiveness, more equitable health outcomes, and social and financial risk protection. This guidance is relevant for all settings and should, therefore, be considered as global guidance.