This class-tested text reflects the refinements made in previous editions while expanding, updating, and adding new information on many important topics. Adopting a bio-organic emphasis, it introduces functional groups early in the text, providing an overview of and preparation for subsequent discussions. This edition includes increased coverage of Carbon 13 spectra; an expanded treatment of conformational effects of molecules, with two sections covering basic geometries of molecules and an in-depth overview of the subject; plus new material on transition metal chemistry and carbohydrate metabolism. Worked-out examples have been added to chapters on synthesis, and end-of-chapter problems have been expanded by more than 200. The text also includes exceptional full-color graphics illustrating conformational effects and general stereochemical properties of organic substances.