Vitamin Binding Proteins
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| Author | : Peter B. Soeters |
| Publisher | : Academic Press |
| Total Pages | : 336 |
| Release | : 2021-04-01 |
| Genre | : Science |
| ISBN | : 0128204222 |
Reciprocal Translation Between Pathophysiology and Practice in Health and Disease brings a novel perspective, closing the knowledge gap between normal/abnormal physiology. Chapters describe the basic mechanisms underlying a disease or trauma-related response, describe consequences in practice, and provide insights on how to use information to better understand disease outcomes. Other sections explore how these responses are beneficial and driven by similar hormones and inflammatory immune cell derived modulators. This is a must-have resource for those seeking an authoritative and comprehensive understanding on how to treat the basic mechanisms underlying disease or trauma-related responses.With contributions from Petronella L.M. Reijven. - Provides an overview of fundamental/foundational content and then goes on to translate the information to more clinically-oriented perspectives - Highlights the benefit of normal pathophysiological response to stress and the misunderstandings surrounding the treatment of this response - Explains how treatment should be adapted to support the inflammatory response and how to treat its inflammatory cause - Includes case studies and slides
| Author | : Gerald F. Combs Jr. |
| Publisher | : Academic Press |
| Total Pages | : 599 |
| Release | : 2012-04-20 |
| Genre | : Technology & Engineering |
| ISBN | : 0123819814 |
The fourth edition of this bestselling text will again provide the latest coverage of the biochemistry and physiology of vitamins and vitamin-like substances. Extensively revised and expanded on the basis of recent research findings with enlarged coverage of health effects of vitamin-like factors, it is ideally suited for students and an important reference for anyone interested in nutrition, food science, animal science or endocrinology. It contains a cohesive and well-organized presentation of each of the vitamins, as well as the history of their discoveries and current information about their roles in nutrition and health. - Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries - Includes approximately 30% new material - Substantial updates have been made to chapters on vitamins A, C, E, K, folate, and the quasi-vitamins - Provides checklists of systems affected by vitamin deficiencies and food sources of vitamins - Key concepts, learning objectives, vocabulary,case studies, study questions and additional reading lists are included making this ideally suited for students - Thoroughly updated with important recent research results, including citations to key reports, many added tables and several new figures - Addition of Health and Nutrition Examination Survey (HANES III) data - Updated Dietary Reference Values
| Author | : Daniel David Bikle |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2020 |
| Genre | : |
| ISBN | : |
There is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial. Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status. The free hormone hypothesis states that protein-bound hormones are inactive while unbound hormones are free to influence biological activity. The majority of circulating 25(OH)D and 1,25(OH)2D is tightly bound to vitamin D binding protein (DBP), 10 -15% is bound to albumin, and less than 1% of circulating vitamin D exists in an unbound form. While DBP is relatively stable in most healthy populations, recent studies have shown that there are gene polymorphisms associated with race and ethnicity that could alter DBP levels and binding affinity. Furthermore, in some clinical situations total 25(OH)D levels are altered, and knowing whether DBP is also altered may have implications for diagnosis and treatment. In this Research Topic, we provide a collection of comprehensive research on vitamin D and DBP metabolism among different ethnic population and patients with different diseases.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 798 |
| Release | : 2002-07-19 |
| Genre | : Medical |
| ISBN | : 0309072905 |
This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.
| Author | : Anthony Norman |
| Publisher | : Elsevier |
| Total Pages | : 509 |
| Release | : 2012-12-02 |
| Genre | : Medical |
| ISBN | : 0323141439 |
Vitamin D: The Calcium Homeostatic Steroid Hormone provides a continuing coordinated group of edited critiques of the dynamic state of the science and art of nutrition. The most recent basic advances will be reviewed within the broad framework of the scientific knowledge of food and nutrition, including its application to man, individually and societally. The volumes, authored singly or by invited contributors, will appeal to serious scholars concerned with pure or applied nutrition. This volume comprises 13 chapters, with the first discussing the progress of vitamin D-cholecalciferol from vitamin to steroid hormone. Succeeding chapters then discuss the biological and chemical assay of vitamin D, its metabolites, and analogs; metabolism of vitamin D; and the tissue and subcellular localization of vitamin D and its metabolites. Other chapters cover binding proteins and receptors for vitamin D and its metabolites; interrelationships between vitamin D and other hormones; intestinal effects of vitamin D; vitamin D actions in the kidney; vitamin D actions on bone; and vitamin D and its clinical relationships. This book will be of interest to practitioners in the fields of chemistry, nutrition, and medicine.
| Author | : Dominic J. Harrington |
| Publisher | : Academic Press |
| Total Pages | : 342 |
| Release | : 2018-11-28 |
| Genre | : Medical |
| ISBN | : 0128130512 |
Laboratory Assessment of Vitamin Status provides a comprehensive understanding of the limitations of commonly used approaches used for the evaluation of vitamin status, reducing harm in the general health setting. It outlines the application of 'Best Practice' approaches to the evaluation of vitamin status, giving physicians and other healthcare professionals the opportunity to make evidence-based interventions. Nearly every metabolic and developmental pathway in the human body has a dependency on at least one micronutrient. Currently, the clinical utility of approaches taken by laboratories for the assessment of vitamin status is generally poorly understood, missing the opportunity to diagnosis vitamin deficiencies. This essential reference gives clinical and biomedical scientists an understanding of the limitations of commonly used approaches to the evaluation of vitamin status in the general health setting through change in practice. Nutritionists and dietitians gain an understanding of more sophisticated markers of vitamin status. - Describes specialist assays in sufficient detail to enable laboratories to replicate what is being performed by expert groups - Provides detailed information that supports laboratories in the setting up of methods for the evaluation of vitamin status - Informs laboratories looking for third party providers of specialist investigations - Provides an essential overview of reference ranges for each vitamin
| Author | : Bernhard Kräutler |
| Publisher | : Wiley-VCH |
| Total Pages | : 568 |
| Release | : 1998-03-09 |
| Genre | : Health & Fitness |
| ISBN | : |
This text reviews the important developments in the "B12-field" with regard to biological, chemical, pharmaceutical and medicinal aspects. Topics of particular interest include: biosynthesis of vitamin B12; B12-catalyzed enzymatic reactions and their mechanisms; and structural B12-chemistry
| Author | : A. Giustina |
| Publisher | : Karger Medical and Scientific Publishers |
| Total Pages | : 216 |
| Release | : 2018-03-29 |
| Genre | : Medical |
| ISBN | : 3318063398 |
Vitamin D deficiency is prevalent today not only among the elderly but pervasively throughout all ages of life.This is due, in part, to systemic diseases that affect vitamin D metabolism, to changes in lifestyle, such as insufficient exposure to sunlight, and to increased use of sunscreen. Apart from the obvious effects of vitamin D deficiency on skeletal metabolism, the problem is assuming even greater significance because observational and interventional studies have linked vitamin D deficiency to cardiovascular disease, cancer, and diabetes. This book addresses a variety of important issues that have emerged from this fast-moving area of clinical medicine. The topics include assays of vitamin D and its binding protein, effects on aging and associated complications, primary and secondary states of altered parathyroid hormone secretion, vitamin D in the growing years of children and adolescents, nutritional requirements, and vitamin D as it relates to systemic disorders such as diabetes mellitus. Vitamin D in Clinical Medicine aims to offer new insights, in an evidence-based way, on important issues related to vitamin D. It is written for general practitioners and internists, as well as for endocrinologists, nutritionists, pulmonologists, cardiologists, and oncologists.
| Author | : Colin Kleanthous |
| Publisher | : Frontiers in Molecular Biology |
| Total Pages | : 370 |
| Release | : 2000 |
| Genre | : Carrier proteins |
| ISBN | : 9780199637607 |
The purpose of Protein-Protein Recognition is to bring together concepts and systems pertaining to protein-protein interactions in a single unifying volume. In the light of the information from the genome sequencing projects and the increase in structural information it is an opportune time totry to make generalizations about how and why proteins form complexes with each other. The emphasis of the book is on heteromeric complexes (complexes in which each of the components can exist in an unbound state) and will use well-studied model systems to explain the processes of formingcomplexes. After an introductory section on the kinetics, thermodynamics, analysis, and classification of protein-protein interactions, weak, intermediate, and high affinity complexes are dealt with in turn. Weak affinity complexes are represented by electron transfer proteins and integrincomplexes. Anti-lysozyme antibodies, the MHC proteins and their interactions with T-cell receptors, and the protein interactions of eukaryotic signal transduction are the systems used to explain complexes with intermediate affinities. Finally, tight binding complexes are represented by theinteraction of protein inhibitors with serine proteases and by nuclease inhibitor complexes. Throughout the chapters common themes are the technologies which have had the greatest impact, how specificity is determined, how complexes are stabilized, and medical and industrial applications.
| Author | : David Feldman |
| Publisher | : Elsevier |
| Total Pages | : 1970 |
| Release | : 2005-01-25 |
| Genre | : Medical |
| ISBN | : 0080543642 |
Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.*Most comprehensive, up-to-date two-volume set on Vitamin D*New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more*Further sections on emerging uses for treatments of auto-immune diseases and diabetes*Over 600 illustrations and figures available on CD
