Visualization Of Receptors
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Author | : Gerard Morel |
Publisher | : CRC Press |
Total Pages | : 458 |
Release | : 1997-02-26 |
Genre | : Science |
ISBN | : 9780849326448 |
A multiplicity of methods for visualization are described in Visualization of Receptors. This book of techniques covers immunocytology, radioautography, in situ hybridization, plasmon resonance, RT in vitro PCR, and X-ray crystal structure analysis. Lecturers, researchers, practitioners, technicians, and students will find all the principles and protocols they require and the means of implementing them. Topics discussed include localization of ligands (in vitro or in vivo), visualization of immunoreactivities of ligand and receptor proteins, detection and quantification of mRNA expression, amplification of signals, and determination of 3-D structure. Details of protocols with illustrations of results and commentaries are provided throughout the book.
Author | : Emmanuel Moyse |
Publisher | : CRC Press |
Total Pages | : 205 |
Release | : 2000-11-30 |
Genre | : Science |
ISBN | : 1420042521 |
Radioligand binding in situ is the most sensitive method for detecting available receptors; the success and reliability of this approach are determined by a number of technical requirements and constraints. Based on the authors' fifteen years of experience in the field, Visualization of Receptors In Situ: Applications of Radioligand Binding explici
Author | : Johannes Passchier |
Publisher | : |
Total Pages | : 113 |
Release | : 2001 |
Genre | : |
ISBN | : |
Author | : Steven Sidney Wolf |
Publisher | : |
Total Pages | : 90 |
Release | : 1983 |
Genre | : |
ISBN | : |
Author | : Marjorie Ariano |
Publisher | : John Wiley & Sons |
Total Pages | : 276 |
Release | : 1998-07-16 |
Genre | : Medical |
ISBN | : 9780471195245 |
The detection of neurotransmitter receptor locations and distribution densities within the central nervous system and peripheral tissues is receiving intense attention within the neuroscience research community. Neurotransmitter receptors, which receive the chemical signals sent from one neuron to another, are critical links in a highly complex information-processing chain. Pinpointing receptor sites and systems is crucial for understanding neurological function as well as dysfunction. It is also essential for understanding how receptors process information when impacted by such substances as heroin or nicotine, or when affected by neurodegenerative disease. Receptor Localization: Laboratory Methods and Procedures is the first user-friendly guide to the latest techniques and approaches being employed to examine the localization of neurotransmitter receptors in the central nervous system and peripheral tissues. It covers detection methods that are applicable to a wide variety of receptor systems, ranging from genes and ligands to in vito receptors in individuals; and to numerous receptor subtypes, such as nicotine, muscarine, tackykinins, dopamine, adenosine, and GABA. The standard laboratory "recipes" or "tricks" employed in these detection methods are fully discussed, as are the advantages and limitations of each procedure. With contributions from leading experts and extensively illustrated, this book: * Discusses receptor ligand binding methods using irreversible and reversible compounds * Presents antireceptor antisera technology using synthetic peptides and fusion proteins at both the cellular and subcellular resolution levels * Examines molecular assessments of receptors * Describes in situ hybridization, reverse transcriptase-PCR, and fluorescent in situ transcription * Covers new visualization paradigms * Includes physiological analysis of receptor function, cellular detection in the brain slice, and cultured neurons * Discusses the use of PET and SPECT to assess in vivo receptor distributions in animals and humans Receptor Localization: Laboratory Methods and Procedures is an invaluable guide for researchers in the related fields of neurology, biochemistry, and pharmacology. Its lucid descriptions of new detection methods, inclusion of experimental examples, and emphasis on how these experimental approaches are applicable to particular research areas will appeal to both the experienced researcher and novice investigator.
Author | : Douglas A. Lauffenburger |
Publisher | : Oxford University Press |
Total Pages | : 376 |
Release | : 1996-01-11 |
Genre | : Science |
ISBN | : 0190283068 |
Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes--from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be conceptually rich, timely, and useful.
Author | : Gintautas Dzemyda |
Publisher | : Springer Science & Business Media |
Total Pages | : 262 |
Release | : 2012-11-08 |
Genre | : Mathematics |
ISBN | : 1441902368 |
This book highlights recent developments in multidimensional data visualization, presenting both new methods and modifications on classic techniques. Throughout the book, various applications of multidimensional data visualization are presented including its uses in social sciences (economy, education, politics, psychology), environmetrics, and medicine (ophthalmology, sport medicine, pharmacology, sleep medicine). The book provides recent research results in optimization-based visualization. Evolutionary algorithms and a two-level optimization method, based on combinatorial optimization and quadratic programming, are analyzed in detail. The performance of these algorithms and the development of parallel versions are discussed. The utilization of new visualization techniques to improve the capabilies of artificial neural networks (self-organizing maps, feed-forward networks) is also discussed. The book includes over 100 detailed images presenting examples of the many different visualization techniques that the book presents. This book is intended for scientists and researchers in any field of study where complex and multidimensional data must be represented visually.
Author | : Gerard Marshall Raj |
Publisher | : Springer Nature |
Total Pages | : 410 |
Release | : 2019-11-16 |
Genre | : Medical |
ISBN | : 9813297794 |
This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.
Author | : Amitabha Chattopadhyay |
Publisher | : CRC Press |
Total Pages | : 230 |
Release | : 2007-05-17 |
Genre | : Medical |
ISBN | : 1420005758 |
A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from l
Author | : Kathryn Elaine Meier |
Publisher | : |
Total Pages | : 344 |
Release | : 1981 |
Genre | : Adrenergic beta blockers |
ISBN | : |