Visualization And Quantification Of 5 Ht1a Receptors In The Living Brain With Pet
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PET in the Evaluation of Alzheimer's Disease and Related Disorders
| Author | : Dan Silverman |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 221 |
| Release | : 2011-04-14 |
| Genre | : Medical |
| ISBN | : 0387764208 |
Among all the clinical indications for which radiologists, nuclear medicine phy- cians, neurologists, neurosurgeons, psychiatrists (and others examining disorders of the brain) order and read brain PET scans, demand is greatest for those pertaining to dementia and related disorders. This demand is driven by the sheer prevalence of those conditions, coupled with the fact that the differential diagnosis for causes of cognitive impairment is wide and often difficult to distinguish clinically. The conceptual framework by which evaluation and management of dementia is guided has evolved considerably during the last decade. Although we still are far from having ideal tests or dramatic cures for any of the established causes of dementia, our options have expanded with respect to both the diagnostic and the- peutic tools now available. In the first chapter of this book, the contribution and limitations of different elements of the clinical examination for diagnosis of cog- tive symptoms are described, and the roles of structural and functional neuroim- ing in the clinical workup are given context.
Serotonin Receptors in Neurobiology
| Author | : Amitabha Chattopadhyay |
| Publisher | : CRC Press |
| Total Pages | : 230 |
| Release | : 2007-05-17 |
| Genre | : Medical |
| ISBN | : 1420005758 |
A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from l
PET and SPECT in Psychiatry
| Author | : Rudi A.J.O. Dierckx |
| Publisher | : Springer Nature |
| Total Pages | : 1075 |
| Release | : 2020-12-14 |
| Genre | : Medical |
| ISBN | : 3030572315 |
This book provides a comprehensive overview of the use of PET and SPECT in the classic psychiatric disorders such as depression, bipolar disorder, anxiety disorders, and schizophrenia. In addition, it discusses the application of these functional neuroimaging techniques in a variety of other conditions, including sleep disorders, eating disorders, autism, and chronic fatigue syndrome. The new edition has been extensively revised and updated to reflect the latest advances and results in nuclear imaging within the field. Most chapters are written jointly by a clinical psychiatrist and a nuclear medicine expert to ensure a multidisciplinary approach. This state of the art compendium will be of value for all who have an interest in the field of neuroscience, from psychiatrists and radiologists/nuclear medicine specialists to interested general practitioners and cognitive psychologists. Companion volumes on the use of PET and SPECT in neurology and for the imaging of neurobiological systems complete a trilogy.
Neuroimaging Research in Geriatric Mental Health
| Author | : Howard J. Aizenstein, MD, PhD |
| Publisher | : Springer Publishing Company |
| Total Pages | : 280 |
| Release | : 2010-02-05 |
| Genre | : Medical |
| ISBN | : 0826111165 |
This volume examines the state-of-the-art in our understanding of the aging brain through the application of brain imaging techniques of neuroscience to the geriatric population. By exploring the neurobiological aspects of geriatric mental health, scientists can begin to understand why abnormal aging happens and what can be done to treat it. Researchers in the fields of geriatric psychiatry, cognitive neuropsychology, neurology, neuroradiology, and physics have combined their expertise to present this accessible, compact review of the field. The chapter authors discuss the use of image modalities and what they can tell us about the aging brain; and present cutting-edge information on image processing and data analysis in the context of geriatric populations. With this book, both novice and seasoned investigators can gain fresh, new insight into geriatric mental health. The use of MRI (magnetic resonance imaging), MRS (magnetic resonance spectroscopy), and other modalities with geriatric populations Single photon emission computed tomography) and PET (positron emission tomography) to geriatric mental health Structural brain changes associated with normal aging Functional neuroanatomy of aging and cognition Brain structural and functional correlates of Alzheimerís dementia and mild cognitive impairment Neuroimaging in late-life schizophrenia
Handbook of the Behavioral Neurobiology of Serotonin
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 1042 |
| Release | : 2020-01-23 |
| Genre | : Medical |
| ISBN | : 0444641262 |
Handbook of the Behavioral Neurobiology of Serotonin, Second Edition, builds on the success of the first edition by continuing to provide a detailed and comprehensive overview of the many facets of behavioral serotonin research. The text expands on the two key topics, behavioral control (sensory processing, ultrasonic vocalization, and melatonin and sleep control) and psychiatric disorders, including its role on psychostimulant abuse and addiction. The new edition includes two new sections on the serotonin systems interactions and the involvement of serotonin in neurological disorders and associated treatment. Serotonin is a major neurotransmitters in the serotonergic system which one of the best studied and understood transmitter systems. Both are critically involved in the organization of all behaviors and in the regulation of emotion and mood. Features two new sections on serotonin systems interactions and serotonin in neurological disorders Focuses on ionotropic and metabotropic 5-HT receptor involvement in behavior Maps receptors and receptor signaling pathways to neurochemical and behavioral outcomes Covers the interactions between serotonin, melatonin and kynurenine pathways
Fluorine In Pharmaceutical And Medicinal Chemistry: From Biophysical Aspects To Clinical Applications
| Author | : Veronique Gouverneur |
| Publisher | : World Scientific |
| Total Pages | : 571 |
| Release | : 2012-04-26 |
| Genre | : Science |
| ISBN | : 1908977892 |
Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging.This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging./a
Emission Tomography
| Author | : Miles N. Wernick |
| Publisher | : Elsevier |
| Total Pages | : 597 |
| Release | : 2004-12-07 |
| Genre | : Science |
| ISBN | : 0080521878 |
PET and SPECT are two of today’s most important medical-imaging methods, providing images that reveal subtle information about physiological processes in humans and animals. Emission Tomography: The Fundamentals of PET and SPECT explains the physics and engineering principles of these important functional-imaging methods. The technology of emission tomography is covered in detail, including historical origins, scientific and mathematical foundations, imaging systems and their components, image reconstruction and analysis, simulation techniques, and clinical and laboratory applications. The book describes the state of the art of emission tomography, including all facets of conventional SPECT and PET, as well as contemporary topics such as iterative image reconstruction, small-animal imaging, and PET/CT systems. This book is intended as a textbook and reference resource for graduate students, researchers, medical physicists, biomedical engineers, and professional engineers and physicists in the medical-imaging industry. Thorough tutorials of fundamental and advanced topics are presented by dozens of the leading researchers in PET and SPECT. SPECT has long been a mainstay of clinical imaging, and PET is now one of the world’s fastest growing medical imaging techniques, owing to its dramatic contributions to cancer imaging and other applications. Emission Tomography: The Fundamentals of PET and SPECT is an essential resource for understanding the technology of SPECT and PET, the most widely used forms of molecular imaging. *Contains thorough tutorial treatments, coupled with coverage of advanced topics *Three of the four holders of the prestigious Institute of Electrical and Electronics Engineers Medical Imaging Scientist Award are chapter contributors *Include color artwork
Brain Plasticity and Epilepsy: A Tribute to Frank Morrell
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 461 |
| Release | : 2000-12-07 |
| Genre | : Medical |
| ISBN | : 008057422X |
This volume of International Review of Neurobiology integrates the latest developments in normal and abnormal neuroplasticity and epilepsy, and considers their implications for understanding the basic mechanisms of normal and pathological behaviors. The chapters are written by leaders in the field, and provide comprehensive coverage of the subject, from molecular neurobiology to behavior. This book will help neuroscientists gain a better understanding of the application of fundamental neuronal mechanisms of plastic change to problems relevant to the diagnosis, treatment, and prevention of human disease, particularly epilepsy.
