Toxins

Toxins
Author: Philip Rosenberg
Publisher: Pergamon
Total Pages: 1178
Release: 1978
Genre: Medical
ISBN:

Natural Toxins

Natural Toxins
Author: D. Eaker
Publisher: Elsevier
Total Pages: 733
Release: 2016-07-29
Genre: Medical
ISBN: 1483146561

Natural Toxins presents the proceedings of the 6th International Symposium on Animal, Plant and Microbial Toxins, held in Uppsala, Sweden on August 1979. This book presents the methods for detection, diagnosis, treatment, and prevention of diseases that natural toxins cause. Organized into 17 parts encompassing 84 chapters, this compilation of papers begins with an overview of the embryonic development, structure, and function of the compound oral glands of venomous and non-venomous snakes in comparison with other exocrine glands. This text then examines the occupational hazards of snakebites in both agriculture and fishing in the Asian areas. Other chapters consider the toxicity and immunological relationships among venoms of several Agkistrodon species. This book discusses as well the characterization of cytotoxins and their mechanisms of action upon model lipid and cell membrane systems. The final chapter deals with neurotoxins as tools for the characterization of molecular components involved in nerve impulse propagation. This book is a valuable resource for biochemists, toxicologists, and pharmacologists.

Handbook of Clinical Toxicology of Animal Venoms and Poisons

Handbook of Clinical Toxicology of Animal Venoms and Poisons
Author: Julian White
Publisher: CRC Press
Total Pages: 50
Release: 1995-08-22
Genre: Medical
ISBN: 9780849344893

The Handbook of Clinical Toxicology of Animal Venoms is the first concise, one-volume book devoted to this important subject. The editors are internationally recognized authorities in the biology and clinical aspects of venomous and poisonous animals, and the chapter authors are world leaders in their respective fields of toxicology. All aspects of the topic are covered including information on the biology and taxonomy of poisonous animals, their venom or poison, diagnosis, and general treatment principles and specific treatment. The most up-to-date list of available antivenoms is provided. Coverage of venomous and poisonous animals is comprehensive, with thorough discussions on shellfish poisoning, ciguatera, fugu, coelenterates, stingrays, venous fish, blue-ringed octopus, sea-snakes, scorpions, spiders, insects, and gila lizards. Individual chapters focus on snakes and snakebite in Europe, Africa, Asia, Australia, North America, Central America, and South America. Nearly all clinical chapters have been written by clinicians with extensive experience treating the particular type of animal envenoming or poisoning under consideration. No other book brings together such a wealth of information in this field, and no other book provides it in a format useful to clinicians charged with the responsibility of treating envenomed or poisoned patients. The Handbook of Clinical Toxicology of Animal Venoms is an essential addition to all medical libraries, emergency departments, toxicology departments, poison information centers, and invaluable to all professionals working in these fields.

Arthropod Venom Components and Their Potential Usage

Arthropod Venom Components and Their Potential Usage
Author: Katsuhiro Konno
Publisher: MDPI
Total Pages: 404
Release: 2020-03-25
Genre: Medical
ISBN: 3039285408

Thousands of arthropod species, ranging from arachnids (spiders and scorpions) to hymenopterans (ants, bees, and wasps) and myriapods (centipedes), are venomous and use their venoms for both defense and predation. These venoms are invariably harmful to humans, and some may cause serious injuries, e.g., those from scorpions, spiders, and wasps. Arthropods’ venoms are also known as rich sources of biologically active compounds and have attracted the attention of toxin researchers for years. In this century, venom component analysis has progressed considerable due to the advances in analytical techniques, in particular, mass spectrometry and next-generation deep (DNA and RNA) sequencing. As such, proteomic and peptidomic analyses using LC–MS have enabled the full analysis of venom components, revealing a variety of novel peptide and protein toxins sequences and scaffolds, potentially useful as pharmacological research tools and for the development of highly selective peptide ligands and therapeutic leads, like chlorotoxin. Due to their specificity for numerous ion-channel subtypes, including voltage- and ligand-gated ion channels, arthropod neurotoxins have been investigated to dissect and treat neurodegenerative diseases and control epileptic syndromes. This Special Issue collects information on such progress, encouraging contributions on the chemical and biological characterization of venom components, not only peptides and proteins, but also small molecules, their mechanisms of action, and the development of venom-derived peptide leads.

An Integrated View of the Molecular Recognition and Toxinology

An Integrated View of the Molecular Recognition and Toxinology
Author: Gandhi Radis-Baptista
Publisher: BoD – Books on Demand
Total Pages: 548
Release: 2013-07-01
Genre: Medical
ISBN: 9535111515

Molecular Toxinology has been consolidated as a scientific area focused on the intertwined description of several aspects of animal toxins. In an inquiring biotechnological world, animal toxins appear as an invaluable source for the discovery of therapeutic polypeptides. Animal toxins rely on specific chemical interactions with their partner molecule to exert their biological actions. The comprehension of how molecules interact and recognize their target is essential for the rational exploration of bioactive polypeptides as therapeutics. Investigation on the mechanism of molecular interaction and recognition offers a window of opportunity for the pharmaceutical industry and clinical medicine. Thus, this book brings examples of two interconnected themes - molecular recognition and toxinology concerning to the integration between analytical procedures and biomedical applications.

Animal Toxins

Animal Toxins
Author: Findlay E. Russell
Publisher:
Total Pages: 462
Release: 1967
Genre: Toxins
ISBN:

Venomous Reptiles and Their Toxins

Venomous Reptiles and Their Toxins
Author: Bryan Fry
Publisher: Oxford University Press
Total Pages: 576
Release: 2015-05-13
Genre: Science
ISBN: 0190297581

Venom research and technology has advanced greatly, rapidly transforming our knowledge of reptile venoms. Research advances, like the development of molecular systematics, provide the framework necessary to reconstruct the evolutionary history of glands and fangs. Such research developments have expanded our understanding of venom's evolution and its usefulness in therapeutic development. The results of this punctuated toxin molecular evolutionary expansion include protein neofunctionalization. While these changes may impact antivenom efficacy, this molecular diversity also facilitates their usefulness in the development of novel drug therapies. Venomous Reptiles And Their Toxins brings together the world's leading toxinologists in this comprehensive study of the entire scope of reptile venoms, from clinical effects to evolution to drug design and development. The book contains detailed applied chapters on clinical care of the envenomed patient, ineffective traditional or modern remedies, occupational considerations involved in the maintenance of institutional venomous reptile collections, veterinary care for venomous reptiles and research methods used in venom research. This book also devotes a chapter to each toxin class found in reptile venoms, detailing the full trajectory of research on the peptide or protein in question. These chapters discuss each toxin's respective role in the envenomation process through to how each has been explored for their biomedical potential. This book is a unique resource for anyone working with venomous reptiles.

Toxins and Drug Discovery

Toxins and Drug Discovery
Author: P. Gopalakrishnakone
Publisher: Springer
Total Pages: 0
Release: 2019-09-11
Genre: Medical
ISBN: 9789400764514

In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.