Validation Of Hydrogen Exchange Mass Spectrometry To Map Protein Folding Landscapes Under Native Conditions
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| Author | : Yawen Bai |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 332 |
| Release | : 2008-02-04 |
| Genre | : Science |
| ISBN | : 1597451894 |
Covering experiment and theory, bioinformatics approaches, and state-of-the-art simulation protocols for better sampling of the conformational space, this volume describes a broad range of techniques to study, predict, and analyze the protein folding process. Protein Folding Protocols also provides sample approaches toward the prediction of protein structure starting from the amino acid sequence, in the absence of overall homologous sequences.
| Author | : Monika Fuxreiter |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 210 |
| Release | : 2012-03-07 |
| Genre | : Medical |
| ISBN | : 1461406595 |
Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.
| Author | : Nikolay V Dokholyan |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 360 |
| Release | : 2012-02-12 |
| Genre | : Science |
| ISBN | : 1461421454 |
Computational modeling is emerging as a powerful new approach to study and manipulate biological systems. Multiple methods have been developed to model, visualize, and rationally alter systems at various length scales, starting from molecular modeling and design at atomic resolution to cellular pathways modeling and analysis. Higher time and length scale processes, such as molecular evolution, have also greatly benefited from new breeds of computational approaches. This book provides an overview of the established computational methods used for modeling biologically and medically relevant systems.
| Author | : Haruki Nakamura |
| Publisher | : Springer |
| Total Pages | : 270 |
| Release | : 2019-01-08 |
| Genre | : Science |
| ISBN | : 9811322007 |
This book presents a new emerging concept of "Integrative Structural Biology". It covers current trends of the molecular and cellular structural biology, providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and enables the readers to understand the hybrid methods. This book discusses how those integrative models should be represented, validated and archived. A unique highlight of this book is discussion of the data validation and archive, which are big problems in this filed along with the progress of this field. The researchers in biology will be interested in this book as a guide book for learning the current structure biology, but also those in structure biology may use this book as a comprehensive reference to cover broad topics.
| Author | : Jennifer J. Kohler |
| Publisher | : Humana Press |
| Total Pages | : 352 |
| Release | : 2016-05-01 |
| Genre | : Science |
| ISBN | : 9781493962037 |
This comprehensive new resource in Springer s Methods in Molecular Biology series features contributions from leading researchers who provide expert advice and reproducible, cutting-edge protocols for examining glycoproteins through mass spectrometry."
| Author | : |
| Publisher | : |
| Total Pages | : 1938 |
| Release | : 2004 |
| Genre | : Medicine |
| ISBN | : |
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
| Author | : Jenny Presto |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2015-04-17 |
| Genre | : Science |
| ISBN | : 9783319165639 |
This Brief summarizes the current research on the novel BRICHOS domain, which is a chaperone domain found in a variety of proteins and is shown to exhibit anti-amyloidogenic chaperone-like functions. The BRICHOS domain is defined from sequence similarities, lacks established physiological function(s) and is found about 10 distantly related pro-protein families, several of which are associated with human disease. In this work, the authors review the mechanism by which BRICHOS inhibits Aβ aggregation and examine recent results from in vivo experiments where BRICHOS inhibits Aβ aggregation and toxicity in Drosophila melanogaster. BRICHOS is one of nature ́s (more specific) ways to protect against fibril formation, and exploring the potential of using the BRICHOS domain in the fight against Alzeimer's Disease and other amyloid diseases seems highly relevant. This brief is useful for newcomers to this field or researchers in related fields wishing to gain a quick overview of the latest findings.
| Author | : David Wales |
| Publisher | : Cambridge University Press |
| Total Pages | : 696 |
| Release | : 2003 |
| Genre | : Science |
| ISBN | : 9780521814157 |
A self-contained account of energy landscape theory aimed at graduate students and researchers.
| Author | : Richard B. M. Schasfoort |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 555 |
| Release | : 2017-05-30 |
| Genre | : Science |
| ISBN | : 1782627308 |
Surface plasmon resonance (SPR) plays a dominant role in real-time interaction sensing of biomolecular binding events, this book provides a total system description including optics, fluidics and sensor surfaces for a wide researcher audience.
| Author | : The Nuclear Magnetic Resonance Society of Japan |
| Publisher | : Springer |
| Total Pages | : 634 |
| Release | : 2017-11-23 |
| Genre | : Science |
| ISBN | : 9811059667 |
This book describes the advanced developments in methodology and applications of NMR spectroscopy to life science and materials science. Experts who are leaders in the development of new methods and applications of life and material sciences have contributed an exciting range of topics that cover recent advances in structural determination of biological and material molecules, dynamic aspects of biological and material molecules, and development of novel NMR techniques, including resolution and sensitivity enhancement. First, this book particularly emphasizes the experimental details for new researchers to use NMR spectroscopy and pick up the potentials of NMR spectroscopy. Second, the book is designed for those who are involved in either developing the technique or expanding the NMR application fields by applying them to specific samples. Third, the Nuclear Magnetic Resonance Society of Japan has organized this book not only for NMR members of Japan but also for readers worldwide who are interested in using NMR spectroscopy extensively.
