Vaccine Delivery Technology
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| Author | : Blaine Pfeifer |
| Publisher | : Humana |
| Total Pages | : 591 |
| Release | : 2020-11-19 |
| Genre | : Science |
| ISBN | : 9781071607947 |
This volume discusses the vaccine development process and the role delivery concepts contribute to a global goal of effective health outcomes. The chapters in this book cover a wide range of topics such as antigen discovery methods; genetic and protein antigen preparation; preparation of viral vaccines as VLPs; viral and non-viral gene delivery; needle-less or non-invasive delivery technology; vaccine storage; and vaccine administration and assessment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics; lists of the necessary materials and reagents; step-by-step, readily reproducible laboratory protocols; and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Vaccine Delivery Technology: Methods and Protocols is a valuable resource for both novice and expert researchers, in and outside the field, who would like to gain insight into the impactful field of vaccines. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
| Author | : Mariusz Skwarczynski |
| Publisher | : William Andrew |
| Total Pages | : 462 |
| Release | : 2016-09-20 |
| Genre | : Medical |
| ISBN | : 0323400299 |
This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. - Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development - Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development - Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines
| Author | : Virgil Schijns |
| Publisher | : Elsevier |
| Total Pages | : 396 |
| Release | : 2005-12-19 |
| Genre | : Medical |
| ISBN | : 0080457215 |
Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. - Contributions from leading international authorities in the field - Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system - Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator
| Author | : Sunil Thomas |
| Publisher | : |
| Total Pages | : 873 |
| Release | : 2016 |
| Genre | : Vaccines |
| ISBN | : 9781493933877 |
| Author | : Parag Kolhe |
| Publisher | : Elsevier |
| Total Pages | : 386 |
| Release | : 2021-09-08 |
| Genre | : Business & Economics |
| ISBN | : 0128143576 |
Formulation, Development and Manufacturing of Vaccines: The Practical Aspects provides an industry perspective on vaccine product development and manufacture that covers their formulation development, manufacture and delivery/in-use considerations of vaccine production. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and its challenges. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges, including the wide range of vaccine components that may comprise proteins, polysaccharides, protein-polysaccharide conjugates, adjuvants, etc. and the varying stability and behavior of solution- and suspension-based systems. This book is an essential resource for formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students. Includes formulation considerations for various vaccine types, including proteins, polysaccharides, conjugates and live vaccines Considers process development for solution, suspension and lyophilized products Explores the future potential of vaccines, including multi-component vaccines and novel delivery mechanisms/devices
| Author | : Martin J. D'Souza |
| Publisher | : CRC Press |
| Total Pages | : 239 |
| Release | : 2015-06-01 |
| Genre | : Medical |
| ISBN | : 9814613312 |
Recent years have seen the development of novel technologies that use nanoparticles and microparticles to deliver vaccines by the oral and microneedle-based transdermal route of administration. These new technologies enable the formulation of vaccine particles containing vaccine antigens, without loss of their biological activity during the formula
| Author | : Dey, Nilanjan |
| Publisher | : IGI Global |
| Total Pages | : 358 |
| Release | : 2016-10-25 |
| Genre | : Computers |
| ISBN | : 1522510265 |
Video is one of the most important forms of multimedia available, as it is utilized for security purposes, to transmit information, promote safety, and provide entertainment. As motion is the most integral element in videos, it is important that motion detection systems and algorithms meet specific requirements to achieve accurate detection of real time events. Feature Detectors and Motion Detection in Video Processing explores innovative methods and approaches to analyzing and retrieving video images. Featuring empirical research and significant frameworks regarding feature detectors and descriptor algorithms, the book is a critical reference source for professionals, researchers, advanced-level students, technology developers, and academicians.
| Author | : Igor S Lukashevich |
| Publisher | : Springer |
| Total Pages | : 393 |
| Release | : 2014-11-13 |
| Genre | : Medical |
| ISBN | : 3709118182 |
This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.
| Author | : Myrone M. Levine |
| Publisher | : CRC Press |
| Total Pages | : 1120 |
| Release | : 2004-01-28 |
| Genre | : Medical |
| ISBN | : 9780824740719 |
Updated to reflect the wide spectrum of economic, regulatory, financial, ethical, and political issues impacting vaccinology in industrialized and developing nations, the Third Edition pinpoints relevant breakthroughs, trends, and advances in vaccinology and immunization science. The book highlights the most influential developments in vaccine safety, regulation, manufacture, and utilization, as well as clinical trials standardization and monitoring. With contributions from a renowned team of specialists and researchers, this reference tracks the technologies, experimental studies, and international programs that will revolutionize and transform the world of vaccinology in the 21st century.
| Author | : Camilla Foged |
| Publisher | : Springer |
| Total Pages | : 433 |
| Release | : 2014-11-22 |
| Genre | : Medical |
| ISBN | : 1493914170 |
This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.
