As the crowd stood and applauded for the neurophysiologist Du Bois-Reymond’s lecture on August 14, 1872, they did not know that his lecture on the seven riddles of the universe would be long remembered. Scientists at the time believed that science could unlock all of the mysteries of the universe. However, the scientific revolution of the early 20th century fueled by relativity and quantum mechanics would upend the scientific world confirming Du Bois-Reymond’s insights. This book explores the brilliance of Du Bois-Reymond’s life and work and a vastly expanded scientific understanding of these riddles through the modern disciplines of physics, chemistry, and biology. Despite the progress, underlying metaphysical notions still haunt the riddles. Utilizing notions from Whitehead’s Process Philosophy, the author delves into the underlying structure of our universe and outlines the nature of the deity that emerges. Part two of this book examines the riddles consequent demands on theology and religion through the lens of the extraordinary teacher, philosopher, and theologian William DeWitt Hyde. The author clarifies notions about miracles, immortality, and wisdom. This book takes the reader on a vivid, imaginative journey towards unraveling the mysteries of our existence, roles in society, and personal loyalties.