Biological Applications of Raman Spectroscopy Volume 1: Raman Spectra and the Conformations of Biological Macromolecules Edited by Thomas G. Spiro The first of the landmark volumes focusing on biological Raman applications, Volume 1 provides an incisive look at the current research surrounding the conformations of biological macromolecules. Volume 1 considers the varieties of macromolecules—proteins, nucleic acids, and lipids—in isolation and in the organized biological assemblies of ocular lenses, viruses, and membranes. The collective vibrational modes of macromolecules are considered theoretically, and there is a review of the promising area of vibrational optical activity. 1987 (0 471-81573-X) 352 pp. Volume 2: Resonance Raman Spectra of Polyenes and Aromatics The importance of the resonance Raman effect for biological applications is that it can provide dramatically increased sensitivity and selectivity The theory of the effect is presented in Volume 2, which also explores applications to rhodopsin, to the purine and pyrimidine bases of nucleic acids, to the peptide backbone and chromophoric side chains of proteins, to flavins, and, finally, to the introduction of resonance Raman labels into biological systems. 1987 (0 471-81574-8) 367 pp. Volume 3: Resonance Raman Spectra of Heme and Metalloproteins Heme proteins have provided an especially rich opportunity for Raman studies. Volume 3 describes in detail various aspects of work in this area, including applications to chlorophylls and nonheme metalloproteins. Coverage includes heme protein structure and the iron-histidine stretching mode; Raman scattering by cytochrome oxidase and by heme a model compounds; chlorophylls and the photosynthetic membrane; resonance Raman spectroscopy of blue copper proteins; and nonheme respiratory proteins. 1988 (0 471-81575-6) 565 pp.