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| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 16 |
| Release | : 2011-07-28 |
| Genre | : |
| ISBN | : 9264122818 |
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...
| Author | : James M. Parry |
| Publisher | : Humana Press |
| Total Pages | : 433 |
| Release | : 2011-12-07 |
| Genre | : Medical |
| ISBN | : 9781617794209 |
The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study. The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.
| Author | : Ashutosh Kumar |
| Publisher | : Academic Press |
| Total Pages | : 352 |
| Release | : 2017-09-26 |
| Genre | : Science |
| ISBN | : 0128092602 |
Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. - Presents an up-to-date and in-depth review of the current state of mutagenesis research - Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors - Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials
| Author | : Shayne C. Gad |
| Publisher | : CRC Press |
| Total Pages | : 950 |
| Release | : 2006-10-30 |
| Genre | : Medical |
| ISBN | : 142001420X |
Reflecting more than a decade's worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of me
| Author | : Minako Nagao |
| Publisher | : John Wiley & Sons |
| Total Pages | : 398 |
| Release | : 2000-06-15 |
| Genre | : Medical |
| ISBN | : |
Current Toxicology Series Series Editors Diana Anderson Tno Bibra International Ltd, Surrey, UK Michael D Waters Consultant, Chapel Hill, NC, USA Timothy C Marrs Department of Health, London, UK Food Borne Carcinogens Heterocyclic Amines Edited by Minako Nagao, Tokyo University of Agriculture, Japan Takashi Sugimura, National Cancer Center, Japan Food Borne Carcinogens provides a comprehensive review of the genotoxic and carcinogenic activities of heterocyclic amines (HCAs) found in cooked foods. This unique and timely publication describes the latest research and offers an insight into new developments. Key topics covered include: * Combination effects of HCAs in carcinogenesis * Genetic alterations in animal tumours induced by HCAs * Adduct levels yielded in humans by ordinary exposure levels * Genetic polymorphisms in HCA metabolic enzymes and suspected individual differences in susceptibility to HCA carcinogenesis Written by world-renowned experts in the field, this book will be essential reading for toxicologists and cancer researchers working within industry, academia and government, particularly, food scientists, genetic toxicologists, biochemists, nutritionists and those investigating risk evaluation of HCA's and the regulation of environmental carcinogens. It will also be of interest to other scientists involved in the identification of naturally occurring antimutagens and anticarcinogens.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 348 |
| Release | : 2000-12-21 |
| Genre | : Nature |
| ISBN | : 0309070864 |
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
| Author | : Alok Dhawan |
| Publisher | : Humana Press |
| Total Pages | : 0 |
| Release | : 2013-07-30 |
| Genre | : Medical |
| ISBN | : 9781627035286 |
Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetic toxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 12 |
| Release | : 1997-07-21 |
| Genre | : |
| ISBN | : 9264071245 |
The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 113 |
| Release | : 1988-02-01 |
| Genre | : Science |
| ISBN | : 0309038391 |
Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.
| Author | : Andrew Teasdale |
| Publisher | : John Wiley & Sons |
| Total Pages | : 548 |
| Release | : 2022-02-15 |
| Genre | : Medical |
| ISBN | : 1119551218 |
Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.
