Transactions On Computational Systems Biology Xi
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Author | : Ralph-Johan Back |
Publisher | : Springer |
Total Pages | : 343 |
Release | : 2009-10-01 |
Genre | : Computers |
ISBN | : 3642041868 |
This issue on Computational Models for Cell Processes is based on a workshop that took place in Turku, Finland, May 2008. The papers span a mix of approaches to systems biology, ranging from quantitative techniques to computing paradigms inspired by biology.
Author | : Ralph-Johan Back |
Publisher | : Springer Science & Business Media |
Total Pages | : 199 |
Release | : 2011-03-28 |
Genre | : Computers |
ISBN | : 3642197477 |
This book covers Computational Models for Cell Processes, featuring enhanced contributions from the CompMod workshop (2009). Covers a wide range of topics in systems biology, addressing the dynamics and the computational principles of this emerging field.
Author | : Ion Petre |
Publisher | : Springer |
Total Pages | : 241 |
Release | : 2012-11-28 |
Genre | : Computers |
ISBN | : 3642355242 |
The LNCS journal Transactions on Computational Systems Biology is devoted to inter- and multidisciplinary research in the fields of computer science and life sciences and supports a paradigmatic shift in the techniques from computer and information science to cope with the new challenges arising from the systems oriented point of view of biological phenomena. This, the 14th Transactions on Computational Systems Biology volume, guest edited by Ion Petre and Erik de Vink, focuses on Computational Models for Cell Processes and features a number of carefully selected and enhanced contributions, initially presented at the CompMod workshop, which took place in Aachen, Germany, in September 2011. The papers, written from different points of view and following various approaches, cover a wide range of topics within the field of modeling and analysis of biological systems. In addition, two regular submissions deal with models of self-assembling systems and metabolic constraints on the evolution of genetic codes.
Author | : Rodrick Wallace |
Publisher | : World Scientific |
Total Pages | : 238 |
Release | : 2013-01-28 |
Genre | : Mathematics |
ISBN | : 1848169981 |
This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule “magic bullet” interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States — from $200 million in 1950 to $1.2 billion in 2010 — has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness.In place of “magic bullets”, we must now apply “magic strategies” that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies./a
Author | : Elisabetta De Maria |
Publisher | : John Wiley & Sons |
Total Pages | : 468 |
Release | : 2022-11-18 |
Genre | : Science |
ISBN | : 1119716586 |
Systems Biology Modelling and Analysis Describes important modelling and computational methods for systems biology research to enable practitioners to select and use the most suitable technique Systems Biology Modelling and Analysis provides an overview of state-of-the-art techniques and introduces related tools and practices to formalize models and automate reasoning for systems biology. The authors present and compare the main formal methods used in systems biology for modelling biological networks, including discussion of their advantages, drawbacks, and main applications. Each chapter includes an intuitive presentation of the specific formalism, a brief history of the formalism and of its applications in systems biology, a formal description of the formalism and its variants, at least one realistic case study, some applications of formal techniques to validate and make deep analysis of models encoded with the formalism, and a discussion on the kind of biological systems for which the formalism is suited, along with concrete ideas on its possible evolution. Edited by a highly qualified expert with significant experience in the field, some of the methods and techniques covered in Systems Biology Modelling and Analysis include: Petri nets, an important tool for studying different aspects of biological systems, ranging from simple signaling pathways to metabolic networks and beyond Pathway Logic, a formal, rule-based system and interactive viewer for developing executable models of cellular processes Boolean networks, a mathematical model which has been widely used for decades in the context of biological regulation networks Answer Set Programming (ASP), which has proven to be a strong logic programming paradigm to deal with the inherent complexity of biological models For systems biologists, biochemists, bioinformaticians, molecular biologists, pharmacologists, and computer scientists, Systems Biology Modelling and Analysis is a comprehensive all-in-one resource to understand and harness the field’s current models and techniques while also preparing for their potential developments in coming years with the help of the author’s expert insight.
Author | : Corrado Priami |
Publisher | : Springer Science & Business Media |
Total Pages | : 118 |
Release | : 2005-03-30 |
Genre | : Computers |
ISBN | : 3540254226 |
The LNCS journal Transactions on Computational Systems Biology is devoted to inter- and multidisciplinary research in the fields of computer science and life sciences and supports a paradigmatic shift in the techniques from computer and information science to cope with the new challenges arising from the systems oriented point of view of biological phenomena. This first volume of the Transactions on Computational Systems Biology is made up of papers by members of the journal's Editorial Board to provide a representative and smart start-up to the new journal.
Author | : Rodrick Wallace |
Publisher | : Springer Nature |
Total Pages | : 173 |
Release | : 2019-08-20 |
Genre | : Political Science |
ISBN | : 3030264246 |
This book applies cutting-edge methods from cognitive and evolutionary theories to develop models of conflict between hierarchically-structured cognitive entities under circumstances of imprecision, uncertainty and stress. Characterized as friction and the fog-of-war by the Prussian military theorist Carl von Clausewitz, such conditions impair institutional cognition in real-time conflict and pose a real and continuing threat to organizations, such as the US military. In a linked collection of formal essays and a mathematical appendix, the book explores different aspects of cognitive and evolutionary process as conducted under the direction of doctrine that acts as a kind of genome for retention of what is learned through Lamarckian evolutionary selection pressures: armies and corporate entities learn from conflict, and incorporate that learning into their ongoing procedures. The book proposes models and policy solutions for strategic competence. A central feature of the book is a formal description of the famous OODA loop of the US military theorist John Boyd in terms of the Data Rate Theorem that links control and information theories. That description is expanded to cover more fully the impact of stochastic fog-of-war effects on tactical and operational scales of conflict. Subsequent chapters examine in more detail the role of doctrine, and the particular effect of embedding culture on cognitive and Lamarckian evolutionary processes associated with conflict on tactical, operational, and strategic scales and levels of organization. A scientifically sophisticated exercise in applied mathematics, history, evolutionary theory, and ecosystem theory, this book will be appropriate for researchers and students interested in defense, security, and international relations, as well as non-academic career professionals in government and industry.
Author | : Susan Stepney |
Publisher | : Luniver Press |
Total Pages | : 114 |
Release | : 2010-07 |
Genre | : Computers |
ISBN | : 1905986270 |
The study of complex systems is growing rapidly and modelling and simulation tools are an important part of the process. This volume brings together work from a multidisciplinary group of scientists, who are studying a variety of techniques and applications for modelling and simulating complex systems. Building on the success of the 2008 and 2009 CoSMoS workshops, the work presented covers subjects ranging from philosophy, scientific validity, and the modelling and simulation of biological and socio-technical systems.
Author | : Serge Haddad |
Publisher | : Springer |
Total Pages | : 428 |
Release | : 2012-06-06 |
Genre | : Computers |
ISBN | : 3642311318 |
This book constitutes the refereed proceedings of the 33rd International Conference on Applications and Theory of Petri Nets and Concurrency, PETRI NETS 2012, held in Hamburg, Germany, in June 2012. The 18 regular papers and 3 tool papers presented were carefully reviewed and selected from 55 submissions. The book also contains 2 invited talks. All current issues on research and development in the area of Petri nets and related models of concurrent systems are addressed.
Author | : Raina Robeva |
Publisher | : Academic Press |
Total Pages | : 383 |
Release | : 2015-05-09 |
Genre | : Mathematics |
ISBN | : 0128012714 |
Written by experts in both mathematics and biology, Algebraic and Discrete Mathematical Methods for Modern Biology offers a bridge between math and biology, providing a framework for simulating, analyzing, predicting, and modulating the behavior of complex biological systems. Each chapter begins with a question from modern biology, followed by the description of certain mathematical methods and theory appropriate in the search of answers. Every topic provides a fast-track pathway through the problem by presenting the biological foundation, covering the relevant mathematical theory, and highlighting connections between them. Many of the projects and exercises embedded in each chapter utilize specialized software, providing students with much-needed familiarity and experience with computing applications, critical components of the "modern biology" skill set. This book is appropriate for mathematics courses such as finite mathematics, discrete structures, linear algebra, abstract/modern algebra, graph theory, probability, bioinformatics, statistics, biostatistics, and modeling, as well as for biology courses such as genetics, cell and molecular biology, biochemistry, ecology, and evolution. - Examines significant questions in modern biology and their mathematical treatments - Presents important mathematical concepts and tools in the context of essential biology - Features material of interest to students in both mathematics and biology - Presents chapters in modular format so coverage need not follow the Table of Contents - Introduces projects appropriate for undergraduate research - Utilizes freely accessible software for visualization, simulation, and analysis in modern biology - Requires no calculus as a prerequisite - Provides a complete Solutions Manual - Features a companion website with supplementary resources