Toxicology of the Nose and Upper Airways

Toxicology of the Nose and Upper Airways
Author: John B. Morris
Publisher: CRC Press
Total Pages: 452
Release: 2016-04-19
Genre: Medical
ISBN: 1420081888

The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. Toxicology of the Nose and Upper Airways presents a culmination of knowledge gained as a result of both human and experimental

How Tobacco Smoke Causes Disease

How Tobacco Smoke Causes Disease
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
Total Pages: 728
Release: 2010
Genre: Government publications
ISBN:

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Comprehensive Toxicology, Volume 8

Comprehensive Toxicology, Volume 8
Author: R.A. Roth
Publisher: Pergamon
Total Pages: 0
Release: 1999-08-04
Genre: Science
ISBN: 9780080429731

Volume 8 begins with a detailed description of the functional anatomy of the various regions and critical cells of the respiratory tract, from the nasal cavity to the gas exchange region. This section conveys the structural heterogeneity of the respiratory system and how it determines tissue and cellular targets for toxic agents. The next section describes functional and biochemical responses of the lungs to toxic insult and includes chapters on carcinogenic and developmental responses to chemical exposure. The final section comprises over 20 chapters describing injurious effects of selected chemicals of toxicologic interest. Human health concerns as well as mechanisms of toxicity are emphasized. Unlike other volumes that have treated this subject, attention is devoted to effects of toxic agents on both the airways and the pulmonary vasculature.

Nasal Toxicity And Dosimetry Of Inhaled Xenobiotics

Nasal Toxicity And Dosimetry Of Inhaled Xenobiotics
Author: Fred J. Miller
Publisher: CRC Press
Total Pages: 469
Release: 1995-02-14
Genre: Medical
ISBN: 9781560323662

The location and severity of toxic responses in the noses of laboratory animals following inhalation of various compounds is attracting a growing number of researchers. This interest has arisen not only due to types of responses observed, but also because of the increased use of animal toxicological data for assessing human health risks from exposure to these compounds. This work addresses nasal dosimetry and toxicity of Inhaled Xenobiotics.; Originally Published As A Special Issue Of The journal "Inhalation Toxicology", the contributions are derived from a Chemical Industry Institute of Toxicology CIIT symposium held in September 1993 in Durham, North Carolina. The overview articles, covering topics like end points and responses of concern in humans, enable the reader to integrate information contained in later articles which treat the overview subjects in greater depth.; Next, mathematical and physical models that can be used to study the deposition of inhaled compounds in the upper respiratory tracts of humans and animals are considered. Approaches for experimental dosimetry studies and a number of dosimetry case studies are presented. The third series of articles examine chemically induced nasal responses in animals and humans. Integrating all the previous information, the final section discusses the use of nasal dosimetry and toxicity data for assessing human health implications and establishing appropriate exposure limits.

Acute Exposure Guideline Levels for Selected Airborne Chemicals

Acute Exposure Guideline Levels for Selected Airborne Chemicals
Author: National Research Council
Publisher: National Academies Press
Total Pages: 465
Release: 2010-03-18
Genre: Nature
ISBN: 030915233X

This book is the eighth volume in the series Acute Exposure Guideline Levels for Selected Airborne Chemicals, and reviews AEGLs for acrolein, carbon monoxide, 1,2-dichloroethene, ethylenimine, fluorine, hydrazine, peracetic acid, propylenimine, and sulfur dioxide for scientific accuracy, completeness, and consistency with the NRC guideline reports.

Air Pollution, the Automobile, and Public Health

Air Pollution, the Automobile, and Public Health
Author: Sponsored by The Health Effects Institute
Publisher: National Academies Press
Total Pages: 703
Release: 1988-01-01
Genre: Science
ISBN: 0309037263

"The combination of scientific and institutional integrity represented by this book is unusual. It should be a model for future endeavors to help quantify environmental risk as a basis for good decisionmaking." â€"William D. Ruckelshaus, from the foreword. This volume, prepared under the auspices of the Health Effects Institute, an independent research organization created and funded jointly by the Environmental Protection Agency and the automobile industry, brings together experts on atmospheric exposure and on the biological effects of toxic substances to examine what is knownâ€"and not knownâ€"about the human health risks of automotive emissions.

Toxicologic Assessment of Jet-Propulsion Fuel 8

Toxicologic Assessment of Jet-Propulsion Fuel 8
Author: National Research Council
Publisher: National Academies Press
Total Pages: 229
Release: 2003-02-14
Genre: Nature
ISBN: 0309168708

This report provides a critical review of toxicologic, epidemiologic, and other relevant data on jet-propulsion fuel 8, a type of fuel in wide use by the U.S. Department of Defense (DOD), and an evaluation of the scientific basis of DOD's interim permissible exposure level of 350 mg/m3

Encyclopedia of Pharmacy Practice and Clinical Pharmacy

Encyclopedia of Pharmacy Practice and Clinical Pharmacy
Author:
Publisher: Academic Press
Total Pages: 2370
Release: 2019-06-28
Genre: Medical
ISBN: 0128127368

Encyclopedia of Pharmacy Practice and Clinical Pharmacy, Three Volume Set covers definitions, concepts, methods, theories and applications of clinical pharmacy and pharmacy practice. It highlights why and how this field has a significant impact on healthcare. The work brings baseline knowledge, along with the latest, most cutting-edge research. In addition, new treatments, algorithms, standard treatment guidelines, and pharmacotherapies regarding diseases and disorders are also covered. The book's main focus lies on the pharmacy practice side, covering pharmacy practice research, pharmacovigilance, pharmacoeconomics, social and administrative pharmacy, public health pharmacy, pharmaceutical systems research, the future of pharmacy, and new interventional models of pharmaceutical care. By providing concise expositions on a broad range of topics, this book is an excellent resource for those seeking information beyond their specific areas of expertise. This outstanding reference is essential for anyone involved in the study of pharmacy practice. Provides a ‘one-stop’ resource for access to information written by world-leading scholars in the field Meticulously organized, with articles split into three clear sections, it is the ideal resource for students, researchers and professionals to find relevant information Contains concise and accessible chapters that are ideal as an authoritative introduction for non-specialists and readers from the undergraduate level upwards Includes multimedia options, such as hyperlinked references and further readings, cross-references and videos