Toxicology Of Inhaled Materials Volume 75
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| Author | : H.P. Witschi |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 559 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642695213 |
This book deals with the methods and scientific basis of inhalation toxicology. It describes devices and facilities needed to expose animals to inhaled particles and gases as well as approaches to estimating or measuring the fraction of the inhaled material that is retained in the respiratory tract. The book then reviews the evergrowing repertoire of techniques that can be used to measure the responses elicited by the exposure. Quantitative and qualitative anatomical, physiological, and biochemical strategies are discussed in detail. We believe that the toxicology of inhaled materials is an important and timely topic for several'reasons. During the past decade, morbidity and mortality attributable to cardiovascular disease have significantly decreased. Progress in combatting cancer, the second most important cause of death, has been slower, and lung cancer actually became the leading cause of death in men and the second leading cause of cancer death in women. In addition, the incidence of non-neo plastic respiratory diseases such as emphysema, fibrosis, and chronic bronchitis has increased the past decade. In the United States, the National Institutes of Health (NIH) has recently reported that chronic obstructive pulmonary disease affects nearly 10 miliion persons and accounts for 59,000 deaths yearly; indeed, it ranks as the fifth leading cause of death. Because the incidence is increasing, the NIH estimates that it may become the nation's fourth or even third leading cause of death by the year 2000.
| Author | : Fernando Pacheco-Torgal |
| Publisher | : Elsevier |
| Total Pages | : 504 |
| Release | : 2012-08-13 |
| Genre | : Technology & Engineering |
| ISBN | : 0857096354 |
From long-standing worries regarding the use of lead and asbestos to recent research into carcinogenic issues related to the use of plastics in construction, there is growing concern regarding the potential toxic effects of building materials on health. Toxicity of building materials provides an essential guide to this important problem and its solutions.Beginning with an overview of the material types and potential health hazards presented by building materials, the book goes on to consider key plastic materials. Materials responsible for formaldehyde and volatile organic compound emissions, as well as semi-volatile organic compounds, are then explored in depth, before a review of wood preservatives and mineral fibre-based building materials. Issues related to the use of radioactive materials and materials that release toxic fumes during burning are the focus of subsequent chapters, followed by discussion of the range of heavy metals, materials prone to mould growth, and antimicrobials. Finally, Toxicity of building materials concludes by considering the potential hazards posed by waste based/recycled building materials, and the toxicity of nanoparticles.With its distinguished editors and international team of expert contributors, Toxicity of building materials is an invaluable tool for all civil engineers, materials researchers, scientists and educators working in the field of building materials. - Provides an essential guide to the potential toxic effects of building materials on health - Comprehensively examines materials responsible for formaldehyde and volatile organic compound emissions, as well as semi-volatile organic compounds - Later chapters focus on issues surrounding the use of radioactive materials and materials that release toxic fumes during burning
| Author | : Philip Wexler |
| Publisher | : Academic Press |
| Total Pages | : 953 |
| Release | : 2000 |
| Genre | : Medical |
| ISBN | : 0127447709 |
History: -- K.D. Watson, P. Wexler, and J. Everitt. -- Highlights in the History of Toxicology. -- Selected References in the History of Toxicology. -- A Historical Perspective of Toxicology Information Systems. -- Books and Special Documents: -- G.L. Kennedy, Jr., P. Wexler, N.S. Selzer, and L.A. Malley. -- General Texts. -- Analytical Toxicology. -- Animals in Research. -- Biomonitoring/Biomarkers. -- Biotechnology. -- Biotoxins. -- Cancer. -- Chemical Compendia. -- Chemical--Cosmetics and Other Consumer. -- Products. -- Chemical--Drugs. -- Chemical--Dust and Fibers. -- Chemical--Metals. -- Chemicals--Pesticides -- Chemicals--Solvents. -- Chemical--Selected Chemicals. -- Clinical Toxicology. -- Developmental and Reproductive Toxicology. -- Environmental Toxicology--General. -- Environmental Toxicology-- Aquatic. -- Environmental Toxicology--Atmospheric. -- Environmental Toxicology--Hazardous Waste. -- Environmental Toxicology--Terrestrial. -- Environmental Toxicology--Wildlife. -- Ep ...
| Author | : |
| Publisher | : |
| Total Pages | : 572 |
| Release | : 1985 |
| Genre | : Public health |
| ISBN | : |
| Author | : U.S. Department of Transportation |
| Publisher | : Simon and Schuster |
| Total Pages | : 352 |
| Release | : 2013-06-03 |
| Genre | : House & Home |
| ISBN | : 1626363765 |
Does the identification number 60 indicate a toxic substance or a flammable solid, in the molten state at an elevated temperature? Does the identification number 1035 indicate ethane or butane? What is the difference between natural gas transmission pipelines and natural gas distribution pipelines? If you came upon an overturned truck on the highway that was leaking, would you be able to identify if it was hazardous and know what steps to take? Questions like these and more are answered in the Emergency Response Guidebook. Learn how to identify symbols for and vehicles carrying toxic, flammable, explosive, radioactive, or otherwise harmful substances and how to respond once an incident involving those substances has been identified. Always be prepared in situations that are unfamiliar and dangerous and know how to rectify them. Keeping this guide around at all times will ensure that, if you were to come upon a transportation situation involving hazardous substances or dangerous goods, you will be able to help keep others and yourself out of danger. With color-coded pages for quick and easy reference, this is the official manual used by first responders in the United States and Canada for transportation incidents involving dangerous goods or hazardous materials.
| Author | : Ulrich Mohr |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 320 |
| Release | : 2013-03-07 |
| Genre | : Medical |
| ISBN | : 3642613551 |
The International Life Sciences Institute (ILSI), a nonprofit, public foundation, was established in 1978 to advance the sciences of nutrition, toxicology, and food safety. ILSI promotes the resolution of health and safety issues in these areas by sponsoring research, conferences, publications, and educational programs. Through ILSI's programs, scientists from government, academia, and industry unite their efforts to resolve issues of critical importance to the public. As part of its commitment to understanding and resolving health and safety issues, ILSI is pleased to sponsor this series of monographs that consolidates new scientific knowledge, defines research needs, and provides a background for the effective application of scientific advances in toxicology and food safety. Alex Malaspina President International Life Sciences Institute Contents Series Foreword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi Part I. Approaches to Assessing the Toxicity of Airborne Toxicants Chapter 1. Standard-Setting as an Integrative Exercise: Alchemy, Juggling, or Science? . . . . . . . . . . . . . . . . . . . . . . . 1 D. v. Bates Chapter 2. Species Differences in Inhalation Toxicology: Variations in Exposure-Dose Relationships and Macrophage Function. . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 J. D. Brain Chapter 3. Cell Populations of the Respiratory System: Interspecies Diversity in Composition, Distribution, and Morphology . . . . . . . . . . . . . . . . . . . . . . . . 25 e. G. Plopper, A. Mir, J. St. George, N. Tyler, A. Mariassy, D. Wilson, S. Nishio, D. Cranz, J. Heidsiek, and D. Hyde Chapter 4. Comparative Metabolic Basis for the Disposition and Toxic Effects of Inhaled Materials . . . . . . . . . . . . . . . . . 41 A. R. Dahl Part II. Methodological Issues in Designing and Conducting Studies with Laboratory Animals Chapter 5. Exposure Facilities and Aerosol Generation and Characterization for Inhalation Experiments. . . . . . . . . .
| Author | : James W. Fisher |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 598 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642758657 |
The subject of this volume is to review chemical agents which affect blood and blood-forming organs. Significant ad- vances made over the past several years in the purification of several hematopoietic growth factors, such as erythro- poietin and colony stimulating factor; the availability of several other growth factors, such as the interleukins which are important in regulating the production of red blood cells, leukocytes, megakaryocytes and platelets are discus- sed. Numerous toxic chemical substances are being produced in our environment which people are exposed todaily causing a suppression of erythropoiesis, myelopoiesis and megakaryo- cytopoiesis. Attempts to evaluate both the therapeutic role of some of the newer growth factors, such as erythropoietin in the anemia of end stage disease, as well as colony stimu- lating factors in somehematopoietic abnormalities are also covered in this volume. In addition, numerous chemical fac- tors in our environment which suppress major hematopoietic lineages stimulated by erythropoietin, macrophage colony stimulating factor, granulocyte colony stimulating factor, interleukin 1-alpha, 1-beta, 2,3,4,5,6, and 7 are also in- cluded. In addition, chapters on the use of erythropoietin in the treatment of anemia of end stage renal disease can provide the practicing hematologist and nephrologist with updated information on the use of erythropoietin for this disease. The book includes chapters on the fundamental con- trol of hematopoiesis and other mechanisms of action of erythropoietin, and finally an up-to-date overview of the chemotherapy of leukemia. This book will prove useful to in- vestigators in the fields of pharmacology, physiology, nephrology, urology, hematology, pathology, endocrinology, biochemistry, and molecular and cell biology.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 8639 |
| Release | : 2017-12-01 |
| Genre | : Science |
| ISBN | : 0081006128 |
Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
| Author | : Michael A. Bray |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 633 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642732178 |
"Immunopharmacology" , why not "pharmacoimmunology"? Professor H. O. Schild University College London, 1962 An intact immune response is essential for survival, as is evidenced by the various innate immune deficiency syndromes and by the emergence of the acquired immune deficiency syndrome (AIDS) as a pandemic during the last decade. Substances which stimulate the immune response might contribute to the therapy of AIDS and its precursor, AIDS-related syndrome, as well as of other clinical conditions in which immune responses can be diminished, such as carcinoma and infections. In other circumstances, an intact or heightened immune response may pose clinical problems; hence there is need to suppress, or diminish, components of the immune response. For instance, it is necessary to impair cellular immunity in order to ensure lasting acceptance of heterografts and it is already established that agents effective in transplantation are therapeutically effective in an range of autoimmune diseases. More recently, experimental studies have indicated that aberrant manifestations of humoral immunity, as in allergies, may also be amenable to pharmacological intervention.
| Author | : National Library of Medicine (U.S.) |
| Publisher | : |
| Total Pages | : 762 |
| Release | : |
| Genre | : Medicine |
| ISBN | : |
