Toward Precision Medicine

Toward Precision Medicine
Author: National Research Council
Publisher: National Academies Press
Total Pages: 142
Release: 2012-01-16
Genre: Medical
ISBN: 0309222222

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Computer Viruses

Computer Viruses
Author: United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Telecommunications and Finance
Publisher:
Total Pages: 90
Release: 1989
Genre: Computer viruses
ISBN:

Realizing the Information Future

Realizing the Information Future
Author: National Research Council
Publisher: National Academies Press
Total Pages: 320
Release: 1994-02-01
Genre: Computers
ISBN: 0309050448

The potential impact of the information superhighwayâ€"what it will mean to daily work, shopping, and entertainmentâ€"is of concern to nearly everyone. In the rush to put the world on-line, special issues have emerged for researchers, educators and students, and library specialists. At the same time, the research and education communities have a valuable head start when it comes to understanding computer communications networks, particularly Internet. With its roots in the research community, the Internet computer network now links tens of millions of people and extends well into the commercial world. Realizing the Information Future is written by key players in the development of Internet and other data networks. The volume highlights what we can learn from Internet and how the research, education, and library communities can take full advantage of the information highway's promised reach through time and space. This book presents a vision for the proposed national information infrastructure (NII): an open data network sending information services of all kinds, from suppliers of all kinds, to customers of all kinds, across network providers of all kinds. Realizing the Information Future examines deployment issues for the NII in light of the proposed system architecture, with specific discussion of the needs of the research and education communities. What is the role of the "institution" when everyone is online in their homes and offices? What are the consequences when citizens can easily access legal, medical, educational, and government services information from a single system? These and many other important questions are explored. The committee also looks at the development of principles to address the potential for abuse and misuse of the information highway, covering: Equitable and affordable access to the network. Reasonable approaches to controlling the rising tide of electronic information. Rights and responsibilities relating to freedom of expression, intellectual property, individual privacy, and data security. Realizing the Information Future includes a wide-ranging discussion of costs, pricing, and federal funding for network development and a discussion of the federal role in making the best technical choices to ensure that the expected social and economic benefits of the NII are realized. The time for the research and education communities to have their say about the information highway is before the ribbon is cut. Realizing the Information Future provides a timely, readable, and comprehensive exploration of key issuesâ€"important to computer scientists and engineers, researchers, librarians and their administrators, educators, and individuals interested in the shape of the information network that will soon link us all.

Circuits, Packets, and Protocols

Circuits, Packets, and Protocols
Author: James L. Pelkey
Publisher: Morgan & Claypool
Total Pages: 632
Release: 2022-04-19
Genre: Computers
ISBN: 1450397298

As recently as 1968, computer scientists were uncertain how best to interconnect even two computers. The notion that within a few decades the challenge would be how to interconnect millions of computers around the globe was too far-fetched to contemplate. Yet, by 1988, that is precisely what was happening. The products and devices developed in the intervening years—such as modems, multiplexers, local area networks, and routers—became the linchpins of the global digital society. How did such revolutionary innovation occur? This book tells the story of the entrepreneurs who were able to harness and join two factors: the energy of computer science researchers supported by governments and universities, and the tremendous commercial demand for Internetworking computers. The centerpiece of this history comes from unpublished interviews from the late 1980s with over 80 computing industry pioneers, including Paul Baran, J.C.R. Licklider, Vint Cerf, Robert Kahn, Larry Roberts, and Robert Metcalfe. These individuals give us unique insights into the creation of multi-billion dollar markets for computer-communications equipment, and they reveal how entrepreneurs struggled with failure, uncertainty, and the limits of knowledge.

Mosaic

Mosaic
Author:
Publisher:
Total Pages: 56
Release: 1989
Genre: Science
ISBN:

Management of NSFNET

Management of NSFNET
Author: United States. Congress. House. Committee on Science, Space, and Technology. Subcommittee on Science
Publisher:
Total Pages: 192
Release: 1992
Genre: Computers
ISBN:

The Science Subcommittee began its oversight of the implementation of the High-Performance Computing Act of 1991 by focusing on the establishment of the National Research and Education Network (NREN), which will evolve out of the current internet, the National Science Foundation's (NSF) NSFNET. The policy issues under discussion were: providing a level playing field for network services providers; ensuring that the network is responsive to user needs; providing for effective network management; determining the level of consultation that has occurred between the NSF, the network user, and provider communities during the course of developing the policies for governance and operation of the NSFNET backbone; and moving toward the long-term vision for the NREN, including the appropriate roles of the public and private sectors. Included in the hearing report are statements from Bob Traxler and Jerry F. Costello of the House Subcommittee on Science and testimony from the following witnesses: Eric Hood, Federation of American Research Networks and Northwestnet, Inc.; Douglas E. Van Houweling, Merit Network, Inc. and the University of Michigan, Ann Arbor; Mitchell Kapor, Commercial Internet Exchange Association and Electronic Frontier Foundation; Michael M. Roberts, Educom; William L. Schrader, Performance Systems International, Inc. Also included are a statement by A. Nico Habermann and Stephen S. Wolff, National Science Foundation; the Subcommittee and Full Committee markups of H.R. 5344, Amendment to the NSF Act of 1950; and an additional statement submitted for the record by E. Michael Staman, CICNet. (ALF)

Defining a Decade

Defining a Decade
Author: National Research Council
Publisher: National Academies Press
Total Pages: 122
Release: 1997-10-09
Genre: Science
ISBN: 9780309059336

The Net Effect

The Net Effect
Author: Thomas Streeter
Publisher: NYU Press
Total Pages: 232
Release: 2011
Genre: Computers
ISBN: 0814741169

"This book about America's romance with computer communication looks at the Internet, not as a harbinger of the future or the next big thing, but as an expression of the times. Streeter demonstrates that our ideas about what connected computers are for have been in constant flux since their invention. In the 1950s they were imagined as the means for fighting nucelar wars, in the 1960s as systems for bringing mathematical certainty to the messy complexity of social life, in the 1970s as countercultural playgrounds, in the 1980s as an icon for what's good about free markets, in the 1990s as a new frontier to be conquered, and, by the late 1990s, as the transcendence of markets in an anarchist open source utopia. The Net Effect teases out how culture has influenced the construction of the internet and how the structure of the internet has played a role in cultures of social and political thought." -- cover.

Mapping the Brain and Its Functions

Mapping the Brain and Its Functions
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 180
Release: 1991-02-01
Genre: Computers
ISBN: 0309044979

Significant advances in brain research have been made, but investigators who face the resulting explosion of data need new methods to integrate the pieces of the "brain puzzle." Based on the expertise of more than 100 neuroscientists and computer specialists, this new volume examines how computer technology can meet that need. Featuring outstanding color photography, the book presents an overview of the complexity of brain research, which covers the spectrum from human behavior to genetic mechanisms. Advances in vision, substance abuse, pain, and schizophrenia are highlighted. The committee explores the potential benefits of computer graphics, database systems, and communications networks in neuroscience and reviews the available technology. Recommendations center on a proposed Brain Mapping Initiative, with an agenda for implementation and a look at issues such as privacy and accessibility.

Information Technology and the Conduct of Research

Information Technology and the Conduct of Research
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 91
Release: 1989-02-01
Genre: Computers
ISBN: 030903888X

Computers and telecommunications have revolutionized the processes of scientific research. How is this information technology being applied and what difficulties do scientists face in using information technology? How can these difficulties be overcome? Information Technology and the Conduct of Research answers these questions and presents a variety of helpful examples. The recommendations address the problems scientists experience in trying to gain the most benefit from information technology in scientific, engineering, and clinical research.