Frontiers in Neutron Capture Therapy

Frontiers in Neutron Capture Therapy
Author: M. Frederick Hawthorne
Publisher: Springer
Total Pages: 1389
Release: 2013-11-11
Genre: Medical
ISBN: 1461512859

Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.

SERA - An Advanced Treatment Planning System for Neutron Therapy

SERA - An Advanced Treatment Planning System for Neutron Therapy
Author:
Publisher:
Total Pages: 10
Release: 1999
Genre:
ISBN:

The technology for computational dosimetry and treatment planning for Boron Neutron Capture Therapy (BNCT) has advanced significantly over the past few years. Because of the more complex nature of the problem, the computational methods that work well for treatment planning in photon radiotherapy are not applicable to BNCT. The necessary methods have, however, been developed and have been successfully employed both for research applications as well as human trials. Computational geometry for BNCT applications can be constructed directly from tomographic medical imagery and computed radiation dose distributions can be readily displayed in formats that are familiar to the radiotherapy community. The SERA system represents a significant advance in several areas for treatment planning. However further improvements in speed and results presentation are still needed for routine clinical applications, particularly when optimizations of dose pattern is required.

Neutron Capture Therapy

Neutron Capture Therapy
Author: Wolfgang A.G. Sauerwein
Publisher: Springer Science & Business Media
Total Pages: 545
Release: 2012-11-05
Genre: Medical
ISBN: 3642313345

Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.

Neutron Beam Design, Development, and Performance for Neutron Capture Therapy

Neutron Beam Design, Development, and Performance for Neutron Capture Therapy
Author: Otto K. Harling
Publisher: Springer Science & Business Media
Total Pages: 340
Release: 2013-03-08
Genre: Medical
ISBN: 1468458027

For this Workshop, the organizers have attempted to invite experts from all known centers which are engaged in neutron beam development for neutron capture therapy. The Workshop was designed around a series of nineteen invited papers which dealt with neutron source design and development and beam characterization and performance. Emphasis was placed on epithermal beams because they offer clinical advantages and are more challenging to implement than thermal beams. Fission reactor sources were the basis for the majority of the papers; however three papers dealt with accelerator neutron sources. An additional three invited papers provided a summary of clinical results of Ncr therapy in Japan between 1968 and 1989 and overviews of clinical considerations for neutron capture therapy and of the status of tumor targeting chemical agents for Ncr. Five contributed poster papers dealing with NCT beam design and performance were also presented. A rapporteurs' paper was prepared after the Workshop to attempt to summarize the major aspects, issues, and conclusions which resulted from this Workshop. Many people contributed to both the smooth functioning of the Workshop and to the preparation of these proceedings. Special thanks are reserved for Ms. Dorothy K.

Advances in Neutron Capture Therapy

Advances in Neutron Capture Therapy
Author: R.F. Barth
Publisher: Springer Science & Business Media
Total Pages: 776
Release: 2012-12-06
Genre: Medical
ISBN: 1461529786

Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.

A Review of the Recommendations for the Physical Dosimetry of Boron Neutron Capture Therapy (BNCT)

A Review of the Recommendations for the Physical Dosimetry of Boron Neutron Capture Therapy (BNCT)
Author:
Publisher:
Total Pages: 147
Release: 2008
Genre:
ISBN: 9789279108686

For the development and clinical implementation of the particular type of radiotherapy BNCT, it is of crucial importance that the basic characteristics of the neutron beam free-in-air and of the basic dosimetry quantities in a phantom are determined in a coherent and reproducible way. Consistent dosimetry is a requirement for a reliable comparison with conventional radiotherapy or other treatment modalities and for the safety of patient treatments. This imposes the condition that the basic dosimetric methods must be traceable by international standards. A consortium consisting of most of the BNCT groups in Europe has produced recommendations and guidelines for BNCT dosimetry. The recommendations presented in this report are based on the available knowledge and experience gained so far, including theoretical reviews, systematic experimental comparisons and analysis of the methods at all available European BNCT facilities. Criteria for the selection of the methods and procedures are defined and applied in the recommendations. The recommendations are limited to the basic experimental procedures related to dosimetry prior to clinical treatment, including quality assurance procedures. Guidance on treatment planning and other clinical and biological issues are not the subject of this document. Recommendations are given for: - Beam characterisation, which includes primary and supplementary methods to determine the free-in-air beam profile of neutrons and photons, to determine the neutron and photon profiles in a phantom and to determine the neutron and photon energy distributions. - Beam monitoring, being essential for the accurate dose delivery. - Beam calibration, which includes the definition of the reference conditions, primary and supplementary methods for the determination of the neutron and photon absorbed dose and a review of corrections that are related to dosimetry in mixed fields of neutrons and photons. Although the recommendations are focused on measurement in well-defined reference conditions, dosimetry for non-reference conditions is reviewed for completeness as well. Finally the quality assurance and the uncertainties in the measured quantities are estimated. The report demonstrates the feasibility to establish a collaborative network on a BNCT dosimetry-standard in Europe, with links to North, South America and Asia.

Advances in Boron Neutron Capture Therapy

Advances in Boron Neutron Capture Therapy
Author: International Atomic Energy Agency
Publisher:
Total Pages: 0
Release: 2023-07-31
Genre:
ISBN: 9789201327239

Boron neutron capture therapy (BNCT) is a neutron-based technique that allows selective cancer treatment at the tumour cellular level. BNCT is especially suitable for the treatment of brain, head, neck and skin cancers. Using the reaction between a neutron and boron to selectively destroy cancer cells, BNCT is a treatment that differs radically from conventional radiotherapy and promises to become a more widely adopted option for cancer treatment. BNCT is undergoing a major resurgence of interest around the world as some recent progress in accelerator technology allows the procedure to be undertake in clinics. In addition, the approval of BNCT in Japan as a routine clinical treatment for certain tumour types offers valuable insights for other states considering a similar approach. This publication comprehensively reports on the current state of the science as well as the supporting technology. It covers accelerator-based neutron sources, beam design, physical dosimetry, facility design and operation, pharmaceuticals, radiobiology, dose calculation, treatment planning and clinical trials. It has been written to assist in decision making at the national level as well as offering practical guidance for all those involved in implementation and ongoing management of BNCT programmes.