This book focuses on new experimental and theoretical advances concerning the role of strange and heavy-flavour quarks in high-energy heavy-ion collisions and in astrophysical phenomena. The topics covered include • Strangeness and heavy-quark production in nuclear collisions and hadronic interactions, • Hadron resonances in the strongly-coupled partonic and hadronic medium, • Bulk matter phenomena associated with strange and heavy quarks, • QCD phase structure, • Collectivity in small systems, • Strangeness in astrophysics,• Open questions and new developments.