The Earth-Moon neighborhood is the scene of a large variety of applications that concern asteroids, lunar exploration and space debris in Earth orbit. In particular, recent efforts by the scientific community have focused on the possibility of extending the human operations beyond the radiation belts; of exploiting in-situ resources, either on the lunar surface or on asteroids retrieved to the vicinity of the Earth; and of mitigating the space debris concern by taking advantage of the lunar perturbation. The characteristic dynamics in the cislunar space represents an opportunity for the mission designer, but also a challenge in terms of theoretical understanding and operational control. This Research Topic covers the Earth-Moon dynamics in its complexity and allure, considering the most relevant aspects for both natural and artificial objects, in order to get a new comprehension of the dynamics at stake along with the operational procedures that can handle it.