The Synthesis Of Potential Serine Protease Inhibitors
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A New Class of Serine and Cysteine Protease Inhibitor with Chemotherapeutic Potential
| Author | : |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 1999 |
| Genre | : |
| ISBN | : |
Metastasis and angiogenesis in cancer are dependent on a variety of biologically active compounds including serine protease. Inhibition of proteases such as plasmin is a potential route for suppression of both metastasis and angiogenesis. Synthesis of tetrahydrothiopyran-4-one based inhibitors containing either a dialkylamino chain, a lysine analog side chain and a dipeptide (D-ile-phe or D-ile-Trp), or just the D-ile-phe dipeptide was accomplished. A compound with both the lysine analog side chain and the dipeptide but lacking a carbonyl was also produced.
Design, Synthesis, and Structure-activity Relationships Analysis of Potential Inhibitors of the Serine Protease Thrombin and the Malarial Aspartic Proteases Plasmepsin I and II
| Author | : Anders Dahlgren |
| Publisher | : |
| Total Pages | : 58 |
| Release | : 2002 |
| Genre | : |
| ISBN | : 9789173734486 |
Design and Synthesis of a Potential Inhibitor for DEN2 NS2B/NS3 Serine Protease
| Author | : Yean Kee Lee |
| Publisher | : |
| Total Pages | : 268 |
| Release | : 2011 |
| Genre | : Antiviral agents |
| ISBN | : |
Serpin Structure and Evolution
| Author | : James Whisstock |
| Publisher | : Academic Press |
| Total Pages | : 562 |
| Release | : 2011-11-16 |
| Genre | : Medical |
| ISBN | : 0123859506 |
Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems. This volume in the Methods in Enzymology series comprehensively covers the topic of serpins With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems
