The Synthesis And Structure Of Some 4 Hydroxycoumarins And Their Pharmacological Activity
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| Author | : Ilia Manolov |
| Publisher | : Cambridge Scholars Publishing |
| Total Pages | : 235 |
| Release | : 2021-06-14 |
| Genre | : Medical |
| ISBN | : 1527571084 |
Coumarin is a structural fragment of different natural and synthetic compounds which demonstrate a wide range of pharmacological activities. Its derivatives are of interest in many fields because of their properties as oral anticoagulants or rodenticides, photosensitizers, anti-HIV agents and antibiotics. There has been continuous interest in the synthesis of these compounds. This book describes various experiments for modifying the structure of clinically used anticoagulants, and establishes the structure of the synthesized products through X-ray analysis. It also identifies unexpected structures in this regard, and highlights the usefulness of all these structural modifications through different biological, toxicological and pharmacological experiments.
| Author | : Maria João Matos |
| Publisher | : Mdpi AG |
| Total Pages | : 416 |
| Release | : 2021-12-29 |
| Genre | : Science |
| ISBN | : 9783036527758 |
Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers.
| Author | : Subhash C. Mandal |
| Publisher | : Academic Press |
| Total Pages | : 752 |
| Release | : 2021-10-05 |
| Genre | : Medical |
| ISBN | : 0323900801 |
Herbal Biomolecules in Healthcare Applications presents extensive detailed information on all the vital principles, basics and fundamental aspects of multiple herbal biomolecules in the healthcare industry. This book examines important herbal biomolecules including alkaloids, glycosides, flavonoids, anthraquinones, steroids, polysaccharides, tannins and polyphenolic compounds, terpenes, fats and waxes, proteins and peptides, and vitamins. These herbal biomacromolecules are responsible for different bioactivities as well as pharmacological potentials. A systematic understanding of the extraction, purification, characterization, applications of these herbal biomolecules and their derivatives in healthcare fields is developed in this comprehensive book. Chapters explore the key topics along with an emphasis on recent research and developments in healthcare fields by leading experts. They include updated literature review of the relevant key topics, good quality illustrations, chemical structures, flow charts, well-organized tables and case studies. Herbal Biomolecules in Healthcare Applications will be useful for researchers working on natural products and biomolecules with bioactivity and nutraceutical properties. Professionals specializing in scientific areas such as biochemistry, pharmacology, analytical chemistry, organic chemistry, clinics, or engineering focused on bioactive natural products will find this book useful. - Provides a study of different type of biomolecules from herbal extracts and their bioactivities as well as their application in the healthcare industry - Contributions by global leaders and experts from academia, industry and regulatory agencies, who have been considered as pioneers in the application of herbal biomolecules in the diverse healthcare fields - Includes updated literature review along with practical examples and research case studies
| Author | : Atta-ur Rahman |
| Publisher | : Bentham Science Publishers |
| Total Pages | : 866 |
| Release | : 2010-12-10 |
| Genre | : Medical |
| ISBN | : 1608052079 |
""Frontiers in Medicinal Chemistry" is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. "Frontiers in Medicinal Chemistry" covers all the areas of medicinal chemistry, incl"
| Author | : Joginder Singh Panwar |
| Publisher | : Elsevier |
| Total Pages | : 246 |
| Release | : 2020-08-19 |
| Genre | : Technology & Engineering |
| ISBN | : 0128225556 |
New and Future Developments in Microbial Biotechnology and Bioengineering: Recent Advances in Application of Fungi and Fungal Metabolites: Applications in Healthcare presents an account of recent development and applied aspects of fungi and its metabolites in the healthcare sector. Chapters are written by eminent researchers, emphasizing the incredible role of fungi and its metabolites in the field of medicine. This book offers reference material to all mycologists working on the exploration and usage of medicinal aspects of fungi and fungal metabolites. - Introduces the aspects and advances of fungi and fungal metabolites in healthcare - Includes a description of traditional uses and modern practices on how to harness the potential of fungi and its metabolites in healthcare applications - Provides details surrounding the use of fungi and its metabolites in medical purposes - Describes potential manifold prospects of fungi and fungal metabolites
| Author | : Venketeshwer Rao |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 351 |
| Release | : 2015-09-30 |
| Genre | : Science |
| ISBN | : 9535121707 |
Global dietary recommendations emphasize the consumption of plant-based foods for the prevention and management of chronic diseases. Plants contain many biologically active compounds referred to as phytochemicals or functional ingredients. These compounds play an important role in human health. Prior to establishing the safety and health benefits of these compounds, they must first be isolated, purified, and their physico-chemical properties established. Once identified, their mechanisms of actions are studied. The chapters are arranged in the order from isolation, purification and identification to in vivo and clinical studies, there by covering not only the analytical procedures used but also their nutraceutical and therapeutic properties.
| Author | : Santhosh Penta |
| Publisher | : Academic Press |
| Total Pages | : 191 |
| Release | : 2015-08-07 |
| Genre | : Science |
| ISBN | : 012803873X |
Advances in Structure and Activity Relationship of Coumarin Derivatives covers the structural behavior of various coumarin derivatives for various potential pharmaceutical applications. Based on substitution targeted for active sites, the book takes a rational approach for designing new and specific potent drugs, optimizing existing ones, and developing novel reactions. This focused primer describes the chemical structure and activity of coumarin derivatives to explore the effects of different substituents at specific positions, and their properties for effective bioactivity. - Accessible and current coverage of coumarin derivatives from structure to potential applications - Application of SAR technology to predict bioactivity of the derivatives based on its chemical structure - Information for researchers in medicinal chemistry, pharmaceutical sciences, and related fields
| Author | : Chao-Jun Li |
| Publisher | : John Wiley & Sons |
| Total Pages | : 435 |
| Release | : 2007-06-04 |
| Genre | : Science |
| ISBN | : 0470131438 |
An extensive update of the classic reference on organic reactions in water Published almost a decade ago, the first edition has served as the guide for research in this burgeoning field. Due to the cost, safety, efficiency, and environmental friendliness of water as a solvent, there are many new applications in industry and academic laboratories. More than forty percent of this extensively updated second edition covers new reactions. For ease of reference, it is organized by functional groups. A core reference, Comprehensive Organic Reactions in Aqueous Media, Second Edition: * Provides the most comprehensive coverage of aqueous organicreactions available * Covers the basic principles and theory and progresses to applications * Includes alkanes, alkenes, aromatics, electrophilic substitutions, carbonyls, alpha, beta-unsaturated carbonyls, carbon-nitrogen bonds, organic halides, pericyclic reactions, photochemical reactions, click chemistry, and multi-step syntheses? * Provides examples of applications in industry This is the premier reference for chemists and chemical engineers in industry or research, as well as for students in advanced-level courses.
| Author | : Goutam Brahmachari |
| Publisher | : Elsevier |
| Total Pages | : 492 |
| Release | : 2017-05-18 |
| Genre | : Science |
| ISBN | : 0128097698 |
Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer's disease, Parkinson's disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. - Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery - Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases - Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab
| Author | : Richard O'Kennedy |
| Publisher | : Wiley |
| Total Pages | : 0 |
| Release | : 1997-04-21 |
| Genre | : Science |
| ISBN | : 9780471969976 |
Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, coumarin, and its main metabolite in humans, 7-hydroxycoumarin. It describes in detail every facet of these compounds including history, toxicology, chemistry, metabolism, analysis, clinical, veterinary and other applications, their roles as immunomodulatory agents and speculates on their mode of action.
