The Selected Papers Of Denis Noble Cbe Frs
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| Author | : Denis Noble |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2012 |
| Genre | : Biological models |
| ISBN | : 9781848168428 |
This is a scientific and philosophical autobiography written around a collection of Denis Noble's most significant papers. It traces a remarkable journey from na ve reductionism to a rigorous systems approach to living systems. It is rigorous because Denis Noble was one of the first biologists to construct computer models of cells and organs of the body. His theoretical work is entirely mathematically based, with no room for ambiguity. Far from the denigration of the systems approach as holistic 'hand-waving', his work is now regarded by pharmaceutical companies and regulators as the gold standard of modelling in the development of new medication. Systems Biology is an idea in search of a definition. This book explains why this is true: it is an approach rather than a subject. Denis Noble's work is one of the clearest examples of the systems approach in practice since it reveals the nature of some of the forms of downward causation in multilevel analysis. The story will delight readers who like to see how scientific controversy is resolved, since many of the developments described in each chapter were highly controversial when they occurred.
| Author | : Denis Noble |
| Publisher | : OUP Oxford |
| Total Pages | : 169 |
| Release | : 2008-02-14 |
| Genre | : Science |
| ISBN | : 0191578800 |
What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes. But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism. The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out the systems biology view of life.
| Author | : Peter Coveney |
| Publisher | : Princeton University Press |
| Total Pages | : 336 |
| Release | : 2023-03-28 |
| Genre | : Science |
| ISBN | : 0691223408 |
The visionary science behind the digital human twins that will enhance our health and our future Virtual You is a panoramic account of efforts by scientists around the world to build digital twins of human beings, from cells and tissues to organs and whole bodies. These virtual copies will usher in a new era of personalized medicine, one in which your digital twin can help predict your risk of disease, participate in virtual drug trials, shed light on the diet and lifestyle changes that are best for you, and help identify therapies to enhance your well-being and extend your lifespan—but thorny challenges remain. In this deeply illuminating book, Peter Coveney and Roger Highfield reveal what it will take to build a virtual, functional copy of a person in five steps. Along the way, they take you on a fantastic voyage through the complexity of the human body, describing the latest scientific and technological advances—from multiscale modeling to extraordinary new forms of computing—that will make “virtual you” a reality, while also considering the ethical questions inherent to realizing truly predictive medicine. With an incisive foreword by Nobel Prize–winning biologist Venki Ramakrishnan, Virtual You is science at its most astounding, showing how our virtual twins and even whole populations of virtual humans promise to transform our health and our lives in the coming decades.
| Author | : Malcolm S. Gordon |
| Publisher | : CRC Press |
| Total Pages | : 267 |
| Release | : 2017-05-25 |
| Genre | : Medical |
| ISBN | : 1351966200 |
Animal Locomotion: Physical Principles and Adaptations is a professional-level, state of the art review and reference summarizing the current understanding of macroscopic metazoan animal movement. The comparative biophysics, biomechanics and bioengineering of swimming, flying and terrestrial locomotion are placed in contemporary frameworks of biodiversity, evolutionary process, and modern research methods, including mathematical analysis. The intended primary audience is advanced-level students and researchers primarily interested in and trained in mathematics, physical sciences and engineering. Although not encyclopedic in its coverage, anyone interested in organismal biology, functional morphology, organ systems and ecological physiology, physiological ecology, molecular biology, molecular genetics and systems biology should find this book useful.
| Author | : Denis Noble |
| Publisher | : Cambridge University Press |
| Total Pages | : 315 |
| Release | : 2017 |
| Genre | : Medical |
| ISBN | : 1107176247 |
This book formulates a relativistic theory of biology, challenging the common gene-centred view of organisms.
| Author | : Jean-Pierre Poirier |
| Publisher | : University of Pennsylvania Press |
| Total Pages | : 541 |
| Release | : 1998 |
| Genre | : Biography & Autobiography |
| ISBN | : 0812216490 |
Originally published in French in 1993 (Editions Pygmalion/Gerard Watelet, Paris), and expanded and revised for this translation. The founder of modern chemistry, Lavoisier (1743-1794) was active on commisions connected with agriculture, gunpowder, banking, and finance, and was ultimately executed during the Reign of Terror. This biography recounts Lavoisier's scientific accomplishments and his role in the chemical revolution and early history of organic chemistry and physiology; but it is in the examination of his political and economic activities and accomplishments that it breaks new ground. Annotation copyrighted by Book News, Inc., Portland, OR
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 1571 |
| Release | : 2020-08-24 |
| Genre | : Science |
| ISBN | : 0128160780 |
Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information
| Author | : Etienne Roux |
| Publisher | : Frontiers Media SA |
| Total Pages | : 185 |
| Release | : 2021-03-09 |
| Genre | : Science |
| ISBN | : 2889665747 |
| Author | : George Gerbner |
| Publisher | : Peter Lang Incorporated, International Academic Publishers |
| Total Pages | : 536 |
| Release | : 2002 |
| Genre | : Art |
| ISBN | : |
George Gerbner has been recognized as one of the most influential and prolific media scholars for over four decades. In this text, Morgan (communication, U. of Massachusetts/Amherst) brings together for the first time an extensive collection of Gerbner's writings. Forty-five selections are grouped into sections on Gerbner's early theories about communication, education and the media, early studies of media institutions and content, the theory and method of Cultural Indicators, Gerbner's key writings about violence, samples of Gerbner's Cultural Indicator studies on a variety of topics, and critical studies and opinion pieces on a variety of topics. No subject index. Annotation copyrighted by Book News, Inc., Portland, OR
| Author | : James Campbell |
| Publisher | : Open Court Publishing |
| Total Pages | : 328 |
| Release | : 1995 |
| Genre | : Philosophy |
| ISBN | : 9780812692853 |
Dewey is the most influential of American social thinkers, and his stock is now rising once more among professional philosophers. Yet there has heretofore been no adequate, readable survey of the full range of Dewey's thought. After an introduction situating Dewey in the context of American social and intellectual history, Professor Campbell devotes Part I to Dewey's general philosophical perspective as it considers humans and their natural home. Three aspects of human nature are most prominent in Dewey's thinking: humans as evolutionary emergents, as essentially social beings, and as problem solvers. Part II examines Dewey's social vision, taking his ethical views as the starting point. Underlying all of Dewey's efforts at social reconstruction are certain assumptions about cooperative enquiry as a social method, assumptions which Campbell explains and clarifies before evaluating various criticisms of Dewey's ideas. The final chapter discusses Dewey's views on religion.
