The Search For Biological Active Agents From Actinobacteria 2nd Edition
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Author | : Learn-Han Lee |
Publisher | : Frontiers Media SA |
Total Pages | : 312 |
Release | : 2020-03-27 |
Genre | : |
ISBN | : 2889636399 |
There is a large market demand for new drugs. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread existence of antibiotic-resistant pathogens, have driven this field of research further by looking at all potential sources of natural products. To date, microbes have made a significant contribution to the health and well-being of people globally. The discoveries of useful metabolites produced by microbes have resulted in a significant proportion of pharmaceutical products in today’s market. Therefore, the investigation and identification of bioactive compound(s) producing microbes is always of great interest to researchers. Actinobacteria are one of the most important and efficient groups of natural metabolite producers. Among the numerous genera, Streptomyces have been recognized as prolific producers of useful natural compounds, as they provide more than half of the naturally-occurring antibiotics isolated to-date and continue to emerge as the primary source of new bioactive compounds. Certainly, these potentials have attracted ample research interest and a wide range of biological activities have been subsequently screened by researchers with the utilization of different In vitro and In vivo model of experiments. Literature evidence has shown that a significant number of interesting compounds produced by Actinobacteria were exhibiting either strong anticancer or neuroprotective activity. The further in depth studies have then established the modulation of apoptotic pathway was involved in those observed bioactivities. These findings indirectly prove the biopharmaceutical potential possessed by Actinobacteria and at the same time substantiate the importance of diverse pharmaceutical evaluations on Actinobacteria. In fact, many novel compounds discovered from Actinobacteria with strong potential in clinical applications have been developed into new drugs by pharmaceutical companies. Together with the advancement in science and technology, it is predicted that there would be an expedition in discoveries of new bioactive compounds producing Actinobacteria from various sources, including soil and marine sources. In light of these current needs, and great interest in the scope of this research, this book seeks to contribute on the investigation of different biological active compound(s) producing actinobacteria which are exhibiting antimicrobial, antioxidant, neuroprotective, anticancer activities and similar.
Author | : Dharumadurai Dhanasekaran |
Publisher | : BoD – Books on Demand |
Total Pages | : 401 |
Release | : 2016-02-11 |
Genre | : Science |
ISBN | : 9535122487 |
This book presents an introductory overview of Actinobacteria with three main divisions: taxonomic principles, bioprospecting, and agriculture and industrial utility, which covers isolation, cultivation methods, and identification of Actinobacteria and production and biotechnological potential of antibacterial compounds and enzymes from Actinobacteria. Moreover, this book also provides a comprehensive account on plant growth-promoting (PGP) and pollutant degrading ability of Actinobacteria and the exploitation of Actinobacteria as ecofriendly nanofactories for biosynthesis of nanoparticles, such as gold and silver. This book will be beneficial for the graduate students, teachers, researchers, biotechnologists, and other professionals, who are interested to fortify and expand their knowledge about Actinobacteria in the field of Microbiology, Biotechnology, Biomedical Science, Plant Science, Agriculture, Plant pathology, Environmental Science, etc.
Author | : Sheng Qin |
Publisher | : Frontiers Media SA |
Total Pages | : 231 |
Release | : 2016-11-09 |
Genre | : |
ISBN | : 2889450139 |
Actinobacteria are highly diverse prokaryotes that are ubiquitous in soil, freshwater and marine ecosystems. Although various studies have focused on the ecology of this phylum, data are still scant on the diversity, abundance and ecology of actinobacteria endemic to special and extreme environments, such as gut, plant, alkaline saline soil, deep sea sediments, hot springs and other habitats. Actinobacteria are well-known producers of a vast array of secondary metabolites, many of which have useful applications in medicine and agriculture. Furthermore, actinobacteria also have diverse functions in different environments apart from antibiotic production. For example, actinobacteria are reported to contribute to the break-down and recycling of organic compounds. They play a significant role in fixation of nitrogen, improvement plant growth, biodegradation, bioremediation and environmental protection. Therefore, understanding the actinobacterial diversity and distribution in such special environments is important in deciphering the ecological roles of these microorganisms and for biotechnological bioprospecting. Recent advances in cultivation, DNA sequencing technologies and -omics (metagenomics, metaproteomics etc) methods have greatly contributed to the rapid advancement of our understanding of microbial diversity, function and they interactions with environment. Furthermore, comparative genomic studies can provide overall information about actinobacterial speciation, evolution, metabolism and environment adaptation mechanisms. This research topic comprising reviews and original articles highlights the recent advances regarding the unexpectedly diverse/rare group of actinobacteria with special selective isolation methods or culture-independent methods, as well as their biological activities, ecophysiologica function and mechanisms from diverse special and extreme environments.
Author | : Viswanath Buddolla |
Publisher | : Academic Press |
Total Pages | : 382 |
Release | : 2020-10-15 |
Genre | : Science |
ISBN | : 0128214074 |
Recent Developments in Applied Microbiology and Biochemistry, Vol. 2, provides a comprehensive treatment and understanding on application oriented microbial concepts, giving readers insights into recent developments in microbial biotechnology and medical, agricultural and environmental microbiology. - Discusses microbial proteome analyses and their importance in medical microbiology - Explores emerging trends in the prevention of current global health problems, such as cancer, obesity and immunity - Shows recent approaches in the production of novel enzymes from environmental samples by enrichment culture and metagenomics approaches - Guides readers through the status and recent developments in analytical methods for the detection of foodborne microorganisms
Author | : Nasib Marbun |
Publisher | : European Alliance for Innovation |
Total Pages | : 209 |
Release | : 2023-04-03 |
Genre | : Science |
ISBN | : 1631903896 |
2nd Warmadewa International Conference on Science, Technology and Humanity will be an annual event hosted by Warmadewa Research Institution, Universitas Warmadewa. This year (2022), will be second time WICSTH will be held on 28 - 29 October 2022 at Auditorium Widya Sabha, Universitas Warmadewa Denpasar-Bali, Indonesia. In the direction of generating community’s welfare through the implementation of higher education research in supporting SDGS, this is a momentum to bring together various critical views and thoughts from various fields of science related to strategies that can be done in developing and solving the issues in Science, technology and humanity study. The conference invites delegates from across Indonesia and is usually attended by more than 100 participants from university academics, researchers, practitioners, and professionals across a wide range of industries.
Author | : Surajit de Mandal |
Publisher | : Academic Press |
Total Pages | : 624 |
Release | : 2020-06-02 |
Genre | : Science |
ISBN | : 0128212667 |
Microorganisms are a major part of the Earth's biological diversity. Although a lot of research has been done on microbial diversity, most of it is fragmented. This book creates the need for a unified text to be published, full of information about microbial diversity from highly reputed and impactful sources. Recent Advancements in Microbial Diversity brings a comprehensive understanding of the recent advances in microbial diversity research focused on different bodily systems, such as the gut. Recent Advancements in Microbial Diversity also discusses how the application of advanced sequencing technologies is used to reveal previously unseen microbial diversity and show off its function. - Gives insight into microbial diversity in different bodily systems - Explains novel approaches to studying microbial diversity - Highlights the use of omics to analyze the microbial community and its functional attributes - Discusses the techniques used to examine microbial diversity, including their applications and respective strengths and weaknesses
Author | : Joachim Wink |
Publisher | : Springer |
Total Pages | : 398 |
Release | : 2017-10-19 |
Genre | : Science |
ISBN | : 3319603396 |
This book provides in-depth insights into the biology, taxonomy, genetics, physiology and biotechnological applications of Actinobacteria. It especially focuses on the latter, reviewing the wide variety of actinobacterial bioactive molecules and their benefits for diverse industrial applications such as agriculture, aquaculture, biofuel production and food technology. Actinobacteria are one of the most promising sources of small bioactive molecules and it is estimated that only a small percentage of actinobacterial bioactive chemicals have been discovered to date. Identifying new diverse gene clusters of biotechnological relevance in the genome of Actinobacteria will be crucial to developing advanced applications for pharmaceutical, industrial and agricultural purposes. The book offers a unique resource for all graduate students, researchers and practitioners in the fields of microbiology, microbial biotechnology, and the genetic engineering of Actinobacteria.
Author | : Learn-Han Lee |
Publisher | : Frontiers Media SA |
Total Pages | : 138 |
Release | : 2020-12-09 |
Genre | : Science |
ISBN | : 2889660877 |
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author | : Surajit Das |
Publisher | : Academic Press |
Total Pages | : 864 |
Release | : 2020-09-15 |
Genre | : Science |
ISBN | : 0128200855 |
Microbial and Natural Macromolecules: Synthesis and Applications brings together active scientists and academicians in the field who share updated information and research outcomes from global experts. Microbial macromolecular diversity, molecular composure, genetics, usability of advanced molecular tools and techniques for their study as well as their applicability are discussed with detailed research perspectives. - Illustrates fundamental discoveries and methodological advancements - Discusses novel functional attributes of macromolecules - Updates progress on microbial macromolecular research
Author | : Corrado Tringali |
Publisher | : CRC Press |
Total Pages | : 650 |
Release | : 2011-09-27 |
Genre | : Science |
ISBN | : 1439822298 |
The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics. Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including: Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants, The tremendous potentiality of metabolic engineering of natural products biosynthesis The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.