The Role Of The Muscle Secretome In Health And Disease
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| Author | : Céline Aguer |
| Publisher | : Frontiers Media SA |
| Total Pages | : 140 |
| Release | : 2020-11-19 |
| Genre | : Science |
| ISBN | : 288966130X |
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
| Author | : Juergen Eckel |
| Publisher | : Academic Press |
| Total Pages | : 242 |
| Release | : 2018-06-12 |
| Genre | : Science |
| ISBN | : 0128097191 |
The Cellular Secretome and Organ Crosstalk focuses on the release of peptides and proteins from different organs and their specific functions in metabolic regulation and cell- and organ crosstalk. The book is written for experts in the field, however, for each topic, helpful references are included. The book also includes technical sections that summarize the state-of-the-art of secretome and crosstalk analysis. This book fulfills the need for a resource that comprehensively describes the current knowledge of secretome biology in health and disease. Communication between different organs involves lipids and other small molecules and a host of proteins and peptides comprising the secretome of different organs (organokinome). More than 600 adipokines have been identified, and an increasing number of hepatokines and myokines have recently been discovered with mostly unknown physiological impact. Importantly, an aberrant signature of the organokinome may be critically underlying a variety of metabolic diseases and may determine the individual susceptibility to disease development. - Summarizes our current knowledge on the secretome of different cells and tissues - Dissects auto-, para- and endocrine functions of major secreted peptides and proteins - Analyzes the secretory malfunction of different cells and its impact for disease development - Authored by a leader in the field, presenting a coherent view on this very complex topic
| Author | : Bouzakri Karim |
| Publisher | : |
| Total Pages | : |
| Release | : 2017 |
| Genre | : |
| ISBN | : |
A new positive component of skeletal muscle secretome impact on beta cells and prevent TNF-alpha and cytomix effect on beta cells.Karim Bouzakri, Julien Cherfan, Harzo Hamdard, Carole Mura, Claude Peronet, and Michel Pinget.UMR DIATHEC, EA 7294, Centre Europu00e9en du2019Etude du Diabu00e8te, Universitu00e9 de Strasbourg (UdS), Boulevard Renu00e9 Leriche 67200 Strasbourg, FranceBackground and aims: Inter-organ crosstalk including possible communication between skeletal muscle and beta cells is an important component of normal physiology that may contribute towards the pathophysiology of type 2 diabetes. Indeed, skeletal muscle cells secrete different sets of soluble proteins (myokines) which could act positively or negatively (in health and disease respectively) on the function of distant tissues including pancreatic islets. We have observed that conditioned medium from skeletal muscle of healthy individuals has positive effects on beta cell function. A new myokine, was identified as a cytokine regulated by muscle fiber type. The major aim of this study was to explore the impact of our new myokine (Myo X) on primary sorted beta cells under control conditions and after exposure to TNF-u03b1 or insulin resistance condition medium from skeletal muscle cells.Materials and methods: All studies were performed using sorted rat primary beta cells and human islets exposed to Myo X for 24h. Glucose-stimulated insulin secretion (GSIS) and glucagon secretion was measured by radioimmunoassay and ELISA after 1h at 2.8 mmol/l and/or 1h at 16.7mmol/l glucose. Cell death and proliferation were measured by TUNEL assay and BrdU incorporation respectively. To study the potential beneficial/protective effects of our myokine, beta cells were exposed to it for 24h alone or with addition 20 ng/ml TNF-u03b1 alone or insulin resistance condition medium from skeletal muscle cells. Data are mean u00b1 SE for 5-8 independent experiments.Results: Myo X treatment of rat primary beta cells and human islets for 24h increased GSIS (control: 12.4 u00b1 3.2% content/h; 1u00b5g/ml Myo X: 15.08 u00b1 3.8%*; 10 u00b5g/ml Myo X: 14.1 u00b1 1.8%*; *p
| Author | : Matthew J. Rossman |
| Publisher | : |
| Total Pages | : 70 |
| Release | : 2012 |
| Genre | : Lungs |
| ISBN | : |
| Author | : Bente Klarlund Pedersen |
| Publisher | : |
| Total Pages | : 206 |
| Release | : 1997-01-01 |
| Genre | : Exercise |
| ISBN | : 9781570594205 |
| Author | : Junjie Xiao |
| Publisher | : Springer Nature |
| Total Pages | : 440 |
| Release | : 2020-04-27 |
| Genre | : Medical |
| ISBN | : 9811517924 |
This book shares the latest findings on exercise and its benefits in preventing and ameliorating numerous diseases that are of worldwide concern. Addressing the role of exercise training as an effective method for the prevention and treatment of various disease, the book is divided into eleven parts: 1) An Overview of the Beneficial Effects of Exercise on Health and Performance, 2) The Physiological Responses to Exercise, 3) Exercise and Metabolic Diseases, 4) Exercise and Cardiovascular Diseases, 5) Exercise and Musculoskeletal Diseases, 6) Exercise and Neurological and Psychiatric Diseases, 7) Exercise and the Respiration System, 8) Exercise and Immunity, 9) Exercise and HIV/AIDS, 10) Exercise and Neuropsychiatric Disorders, and 11) Future Prospects. Given its scope, the book will be particularly useful for researchers and students in the fields of physical therapy, physiology, medicine, genetics and cell biology, as well as researchers and physicians with a range of medical specialties.
| Author | : Bruce Spiegelman |
| Publisher | : Springer |
| Total Pages | : 108 |
| Release | : 2018-03-07 |
| Genre | : Science |
| ISBN | : 3319727907 |
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
| Author | : Francesco Travascio |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 376 |
| Release | : 2016-06-15 |
| Genre | : Science |
| ISBN | : 9535124153 |
The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.
| Author | : Nikolic, Marko Z. |
| Publisher | : European Respiratory Society |
| Total Pages | : 395 |
| Release | : 2021-04-01 |
| Genre | : Medical |
| ISBN | : 1849841349 |
Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science
| Author | : Barbara Zavan |
| Publisher | : Humana Press |
| Total Pages | : 288 |
| Release | : 2016-07-25 |
| Genre | : Science |
| ISBN | : 3319332996 |
This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.
