The Role Of Nlr Proteins In Leishmaniasis
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| Author | : Farhat Afrin |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 234 |
| Release | : 2018-10-10 |
| Genre | : Medical |
| ISBN | : 1789841011 |
Leishmania parasites plague the mammalian host causing high morbidity and mortality. The parasites persist in the hostile milieu, crippling its defensive arsenal. In the face of mounting resistance to an antiquated drug arsenal, new approaches are urgently desired to keep the infection at bay. Furthermore, to strengthen the leishmaniasis elimination drive, particular emphasis has to be laid on identification of new targets and vaccination strategies. This book gives a brief glimpse of the epidemiology of leishmaniasis, immune evasion, vaccination, and therapeutic modalities that may work by untangling the immunological cross-wires of pathogenic cross-talk. The Conventional treatment and its drawbacks, the prospects of phytotherapy and nanomedicines, are also discussed. The identification of drug targets with the aim of designing inhibitors is also exemplified.
| Author | : Sergio C. Oliveira |
| Publisher | : Frontiers Media SA |
| Total Pages | : 139 |
| Release | : 2024-11-07 |
| Genre | : Medical |
| ISBN | : 2832556426 |
Innate immunity is the first arm of the immune system to be triggered in host defense against intracellular pathogens. Some pathogens during evolution have developed stealthy strategies to bypass innate surface receptors but when they reach host cell cytosol they are recognized by cytosolic receptors. Professional phagocytes, such as macrophages, neutrophils, or dendritic cells, have the specialized ability to internalize pathogens into membrane-bound compartments, termed phagosomes. Additionally, pathogen phagocytosis effectively guarantees the concentrated delivery of pathogen-associated molecular patterns (PAMPs) inside cells. Some pathogens can exit phagosomes and survive and replicate in the cytosolic space. Several pattern recognition receptors (PRR) have been described over the years. A diverse repertoire of PRRs exists, localized freely in the cytosol or associated with or integrated into cytoplasmic membranes, to detect these organisms. Among these intracellular sensors, several molecules have been identified such as cGAS/STING pathway, the inflammasome platforms (eg: NLRP3, NLRC4, AIM2), caspase-11/4/5, RIG-I, among others. Host cell activation through these receptors leads to cell signaling pathways resulting in inflammatory and anti-inflammatory reactions.
| Author | : Om Prakash Singh |
| Publisher | : Frontiers Media SA |
| Total Pages | : 239 |
| Release | : 2022-02-07 |
| Genre | : Science |
| ISBN | : 2889743454 |
| Author | : Budhaditya Mukherjee |
| Publisher | : Springer Nature |
| Total Pages | : 230 |
| Release | : 2023-01-31 |
| Genre | : Medical |
| ISBN | : 9811982252 |
This book illustrates the importance and significance of the systems approach in deciphering diverse aspects of host-parasite interactions in infection dynamics. It describes the complex issues and state-of-the-art progress in the infection biology of parasitic protozoa. The book explores the current concepts and paradigms of gene expression, metabolome, and immune remodeling in these diseases. The chapters encompass updates on the parasitic tropism, co-evolution, systemic responses in hosts, and translational approaches. It provides an overview of the parasite's efficient ways of exploiting host molecules and describes pathways for their survival, differentiation, and replication within the host cells. The book also delineates the role of inflammasomes and their activation in response to the protozoan parasite. The book discusses technological progress and machine learning-based modeling approaches to revisit parasitic infection from a non-conventional perspective. Collectively this book offers a comprehensive purview of concepts and paradigms in parasitic infection in the form of an updated yet discernible elucidation.
| Author | : J. Robin Harris |
| Publisher | : Springer Nature |
| Total Pages | : 580 |
| Release | : 2020-11-30 |
| Genre | : Science |
| ISBN | : 3030589714 |
This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
| Author | : Mukesh Samant |
| Publisher | : Academic Press |
| Total Pages | : 281 |
| Release | : 2021-08-18 |
| Genre | : Medical |
| ISBN | : 0128227982 |
Leishmaniasis is a neglected tropical disease that is known to be transmitted by 90 different species of sandflies which carry 20 Leishmania species that cause human infection particularly in endemic countries. Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to provide information on this vector-borne disease and explore strategies for diagnosis and treatment. The book begins with an overview of leishmaniasis which includes historical and future perspectives of the disease. It also discusses the clinical manifestation of the disease, mechanisms of infection, therapeutic strategies, diagnostics, prevention, and cure of Leishmania parasite. The book goes on to explain new insights and challenges in the development of promising drug targets, biomarkers identification and advance vaccination strategies against leishmaniasis. Chapter contributions brings together diverse areas of expertise making Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to bring together elements of leishmaniasis into one place and be a valuable resource for researchers, health care professionals, and graduate students, working in the field of leishmaniasis. - Provides an overview Leishmania and leishmanisis which include its history, transmission, clinical picture, and treatment - Discusses novel approaches to study parasite infection and treatment - Explores recent advances in the development of diagnostic kits, drug development and various vaccination strategies
| Author | : J.P. Dubey |
| Publisher | : CRC Press |
| Total Pages | : 512 |
| Release | : 2017-07-12 |
| Genre | : Medical |
| ISBN | : 1351648608 |
Key features: Written by the scientist who named this parasite and was the first to set up proper diagnostic techniques Serves as the first ever book to provide information on the parasite structure, biology, pathogenesis, clinical signs, epidemiology, prevention, and control of neosporosis Covers both approaches toward preventing & controlling this disease: Developing an efficacious vaccine and sound cattle management practices Contains a wealth of illustrations, including many of the author's original photographs of the parasite Provides basic information on immunologic and molecular aspects of the disease Abortion is a worldwide problem in the livestock industry accounting for annual economic losses of billions of dollars, and N. caninum is a major cause of it. Neosporosis is a newly recognized disease of animals. Until 1988 it was misdiagnosed as toxoplasmosis. Considerable progress in understanding the biology of neosporosis has been made in the last 30 years, resulting in more than 2,000 scientific publications. The economic importance of abortion in cattle, and the availability of knowledge, reagents, and technology used to study toxoplasmosis, have contributed to the rapid progress in understanding the biology of neosporosis. Written by pioneers in this field, Neosporosis in Animals presents a comprehensive summary of the biology of neosporosis, starting with chapter 1 on the historical background of the discovery of the disease. Subsequent chapters deal with general aspects of the biology of N. caninum (chapter 2), techniques (chapter 3), and the disease caused by this parasite in cattle (chapter 4), dogs (chapter 5), and all other animals including sheep, pigs, primates and humans (chapters 6-18). This book provides, for the first time in a single authoritative source, a complete account of the structure, biology, clinical disease, diagnosis, epidemiology, treatment, attempts at immunoprophylaxis, and control in all hosts. There are 175 illustrations and tables devoted to the life cycle, structure of parasitic stages, and lesions. More than 2100 references are cited, allowing the reader to locate additional information on specific topics in an efficient way. This book will be useful to a broad range of researchers in biology and veterinarians.
| Author | : Edward T Ryan |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 1265 |
| Release | : 2019-03-25 |
| Genre | : Medical |
| ISBN | : 0323625509 |
New emerging diseases, new diagnostic modalities for resource-poor settings, new vaccine schedules ... all significant, recent developments in the fast-changing field of tropical medicine. Hunter's Tropical Medicine and Emerging Infectious Diseases, 10th Edition, keeps you up to date with everything from infectious diseases and environmental issues through poisoning and toxicology, animal injuries, and nutritional and micronutrient deficiencies that result from traveling to tropical or subtropical regions. This comprehensive resource provides authoritative clinical guidance, useful statistics, and chapters covering organs, skills, and services, as well as traditional pathogen-based content. You'll get a full understanding of how to recognize and treat these unique health issues, no matter how widespread or difficult to control. - Includes important updates on malaria, leishmaniasis, tuberculosis and HIV, as well as coverage of Ebola, Zika virus, Chikungunya, and other emerging pathogens. - Provides new vaccine schedules and information on implementation. - Features five all-new chapters: Neglected Tropical Diseases: Public Health Control Programs and Mass Drug Administration; Health System and Health Care Delivery; Zika; Medical Entomology; and Vector Control – as well as 250 new images throughout. - Presents the common characteristics and methods of transmission for each tropical disease, as well as the applicable diagnosis, treatment, control, and disease prevention techniques. - Contains skills-based chapters such as dentistry, neonatal pediatrics and ICMI, and surgery in the tropics, and service-based chapters such as transfusion in resource-poor settings, microbiology, and imaging. - Discusses maladies such as delusional parasitosis that are often seen in returning travelers, including those making international adoptions, transplant patients, medical tourists, and more. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.
| Author | : Martin Flajnik |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 3597 |
| Release | : 2022-07-19 |
| Genre | : Medical |
| ISBN | : 1975142527 |
Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.
| Author | : Nima Rezaei |
| Publisher | : Springer |
| Total Pages | : 593 |
| Release | : 2016-11-30 |
| Genre | : Medical |
| ISBN | : 3662529092 |
The number of diagnosed cases of primary immunodeficiency diseases (PIDs) – a group of inborn disorders of the immune system – is growing rapidly, but misdiagnosis or late diagnosis still occurs in a significant number of patients, with serious consequences. This is the second edition of a practical reference textbook on PIDs that has been widely welcomed by scientists and clinicians from around the world. The new edition has been extensively revised to reflect advances in knowledge and includes various PIDs not previously covered. For each disease, information is provided on definition, etiology, clinical manifestations, diagnosis, and management. This book will represent an ideal resource for specialists when engaging in diagnosis, clinical decision-making, and treatment planning. It will also prove invaluable for doctors in training and other physicians and nurses who wish to learn more about PIDs.
