The Quinolones
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Author | : Vincent T. Andriole |
Publisher | : Elsevier |
Total Pages | : 540 |
Release | : 2000-10-09 |
Genre | : Medical |
ISBN | : 0080525784 |
Quinolones constitute a large class of synthetic antimicrobial agents that are highly effective in the treatment of many types of infectious diseases, particularly those caused by bacteria. New quinolones are continually being developed as bacterial species develop resistance to existing quinolones. This book presents the most current information available in our continual struggle to conquer disease. Over time, bacteria become resistant to medicines that are used to combat them. Because of this, the medical world is always in search of new and improved ways to battle these disease-causing bacteria. Quinolones are at the forefront of this research. Edited by one of the world's foremost authorities on the subject, the third edition of this highly successful title will serve as a valuable tool for primary care physicians and researchers interested in a comprehensive, up-to-date reference on the chemistry, mechanisms of action, development of resistance, and clinical efficacy of both currently available and newer quinolone compounds under investigation. This is the eagerly anticipated fully revised edition of the standard reference in the field. - Eagerly anticipated updated edition of noted title covering synthetic microbial agents that are useful against infectious disease, particularly those caused by bacteria - Edited by one of the foremost experts in the field of quinolone research and infectious disease - History of quinolones, chemistry & mechanisms of action, pharmacology, safety aspects - Role of quinolones in treating various types of infections, including respiratory infections, gastrointestinal infections, urinary tract infections, prostatitis, STDs and bacterial meningitis as well as their use in immunocompromised patients
Author | : Jón Karlsson |
Publisher | : |
Total Pages | : 426 |
Release | : 2014 |
Genre | : Achilles tendon |
ISBN | : 9780955887345 |
Author | : |
Publisher | : Academic Press |
Total Pages | : 290 |
Release | : 2019-07-13 |
Genre | : Medical |
ISBN | : 0128173173 |
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
Author | : Johannes Ring |
Publisher | : Springer Science & Business Media |
Total Pages | : 577 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642467172 |
The international symposium "New Trends in Allergy", held in Munich from July 13 to 15, 1990, brought together for the third time since 1980 some of the most experienced researchers working in the field of allergy. This volume comprises the papers presented at this meeting. All over the world, and not merely in the industrialized countries, allergy is becoming a cause of evermore serious diseases. In recent years, research in the field of allergy has provided numerous impor tant and fascinating results extending our knowledge considerably. Despite the new insights into basic mechanisms of allergic reactions, improved diagnostic methods, and new therapeutic approaches, how ever, many questions remain to be answered, including: Are allergies really increasing in frequency? If so, what are the reasons? Especially, does environmental pollution playa role? Which factors influence IgE synthesis? Can the IgE immune response be switched off? Does the nervous system interact with allergic reactions? If so, what are the mechanisms? Are new approaches in allergy prophylaxis and allergy therapy effi cient? What measures have proven useful and deserve to be employed in daily practice? In this volume, these questions and other current topics are dealt with. As each issue is covered by authors competent in the respective fields, the result is an extensive and critical review of the state of the art. Going through these papers, one comes to the conviction that allergy research is a multifacetted, explosively expanding, most stimulating field of work.
Author | : Stefan Pieper |
Publisher | : Springer Nature |
Total Pages | : 76 |
Release | : 2021-06-08 |
Genre | : Medical |
ISBN | : 3030741737 |
In this book, Stefan Pieper supports doctors and therapists in easily diagnosing FQAD and in better and more adequately dealing with FQAD patients. Fluoroquinolones, as one of the most common and effective groups of antibiotics, are known to have a distinct spectrum of side effects. These adverse effects are rare in percentage terms, but frequent in absolute numbers due to the enormous quantities of prescriptions. Because they are usually quite severe and wide-ranging, they tend to run like a syndrome and have been classified by the FDA as a separate condition, the FQAD, because of their frequency, severity and risk of disability. This book presents for the first time a comprehensive description and classification of the clinical picture and a proposal for a clinical diagnostic tool based on diagnostic criteria.
Author | : Indranil Samanta |
Publisher | : Academic Press |
Total Pages | : 394 |
Release | : 2019-09-25 |
Genre | : Medical |
ISBN | : 0128165235 |
Antimicrobial Resistance in Agriculture: Perspective, Policy and Mitigation is a valuable industrial resource that addresses complex, multi-factorial topics regarding farm, wild, companion animals, fish, and how the environment plays an important role in amplification and transmission of resistant bugs into the human food chain. Information of phenotypical and genotypical properties of each bacterial genus associated with antimicrobial resistance, transmission dynamics from different reservoirs (food animals, poultry, fishes) and control measures with alternative therapy, such as phytobiotics and nanomaterials are provided. Researchers, scientists and practitioners will find this an essential resource on the judicial use of antibiotics in animals and humans. - Explores all the genera of livestock and fish originated pathogenic bacteria associated with antimicrobial resistance - Presents cutting-edge research on epigenetics, nanotechnology and intervention technologies - Discusses transmission dynamics of resistance gene pools from different reservoirs, including food animals, poultry, fishes and the environment
Author | : Hyman J. Zimmerman |
Publisher | : Lippincott Williams & Wilkins |
Total Pages | : 850 |
Release | : 1999 |
Genre | : Medical |
ISBN | : 9780781719520 |
Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Author | : Vincent T. Andriole |
Publisher | : Academic Press |
Total Pages | : 275 |
Release | : 2013-10-22 |
Genre | : Medical |
ISBN | : 1483216039 |
The Quinolones covers reviews on the history, chemistry and mechanism of action, in vitro properties, pharmacokinetics, clinical overview, toxicity, adverse effects and drug interactions, and future prospects of the 4-quinolones. The book discusses the microbiology of quinolones, particularly with consideration of the development of resistance, pharmacology, toxicology, and clinical uses. Chemists, microbiologists, pharmacologists and clinicians will find the book useful.
Author | : Jay Cohen |
Publisher | : |
Total Pages | : 206 |
Release | : 2015-10-25 |
Genre | : |
ISBN | : 9781518626869 |
This book is about the powerful, sometimes lifesaving, yet sometimes highly destructive antibiotics known as fluoroquinolones. Best known of these drugs are Cipro (ciprofloxacin) and Levaquin (levofloxacin), as well as four others. This book, How We Can Halt the Cipro and Levaquin Catastrophe: the Worst Medication Disaster in U.S. History, has two main goals. The first goal is to alert patients and doctors of the truly destructive capability of these drugs to cause serious, sometimes long term, sometimes permanent injuries. The capacity of these drugs for such damage has been attested by the U.S. Food and Drug Administration and others many times and is by now incontrovertible. Hundreds of patients, many of whom are quoted in this book, have confirmed their long-lasting injuries to me, while many hundreds more have been ignored or dismissed by their doctors. This must stop. Ignoring these problems has only made the problem worse. My second goal in writing How We Can Halt the Cipro and Levaquin Catastrophe: the Worst Medication Disaster in U.S. History is to stimulate the interest of government, the drug industry, medical institutions and all others for any and all ideas regarding remedies, solutions, and any other ideas that may help end the suffering experienced by patients with the Fluoroquinolone Toxicity Syndrome that can affect many human systems including the musculoskeletal, nervous, psychiatric, gastrointestinal, and others. As you will see, I have offered some ideas for therapies that may provide benefit to some of the injured. I think it is imperative that we follow a trail that may lead us to an understanding of how these drugs work and particularly how they injure, and most of all how we might help people heal, obtain pain reduction and hope. Thousands of lives, young and old, depend on the efforts that we make.
Author | : Jochen Kuhlmann |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2012-02-12 |
Genre | : Medical |
ISBN | : 9783642803666 |
It has been over 30 years since the first clinically important member of the quinolone class, nalidixic acid, was introduced into medical practice. The modification produced in the quinolone nucleus by introducing a fluorine at the 6-position led to the discovery of the newer fluoroquinolones with enhanced antibacterial activities as compared to nalidixic acid. By now a great deal of preclinical and clinical experience has been obtained with these agents. The intense interest in this class of antibacterial agents by chemists, micro biologists, toxicologists, pharmacologists, clinical pharmacologists, and clini cians in various disciplines encouraged us to summarize the information on the history, chemistry, mode of action and in vitro properties, kinetics and efficacy in animals, mechanisms of resistance, toxicity, clinical pharmacology, clinical experience, and future prospects in one volume of the Handbook of Experimental Pharmacology. As this series deals predominantly with "experimental" characteristics of drugs, our volume is dedicated specifically to quinolones and emphasizes principally their preclinical and clinical phar macological characteristics, despite the existence of several summaries on quinolones. The chemistry of the quinolones is described in detail. The chapter on the mode of action of quinolones reports the conclusive evidence that gyrase is the intracellular target of the quinolones; however, another enzyme, topoisomerase IV, may also be a target for quinolones, and the exact mechanisms by which quinolones act bactericidally are far from being understood.