The Quantitative Analysis Of Polychlorinated Biphenyls And Their Metabolites By Gas Chromatography And Ion Molecule Reaction Detection In A Tandem Mass Spectrometer
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Author | : Ronald Franklin Lopshire |
Publisher | : |
Total Pages | : 360 |
Release | : 1994 |
Genre | : Gas chromatography |
ISBN | : |
Author | : |
Publisher | : |
Total Pages | : 896 |
Release | : 1995 |
Genre | : Dissertation abstracts |
ISBN | : |
Author | : Frederick William Grothkopp |
Publisher | : |
Total Pages | : 57 |
Release | : 1981 |
Genre | : Biphenyl compounds |
ISBN | : |
Author | : |
Publisher | : |
Total Pages | : 594 |
Release | : 1999 |
Genre | : Mass spectrometry |
ISBN | : |
Author | : Jocelyn Munoz Jaramillo |
Publisher | : |
Total Pages | : |
Release | : 2018 |
Genre | : |
ISBN | : 9780438629899 |
Polychlorinated biphenyls (PCBs) are a class of synthetic, aromatic, organic chemicals that were produced as complex commercial mixtures. Although the production and use of PCBs is now banned due their lipophilic, bioaccumulative, persistent, and toxic properties, they are still one of the most ubiquitous pollutants in the environment. Currently, several validated methods for the quantitation of PCBs from biological matrices exist; however, they often employ the use of expensive, hazardous, or tedious extraction methods. Specifically, previous methods rely heavily on the use of large solvent volumes, multiple extractions, evaporation techniques, extensive clean-up procedures, and potential derivatization of analytes; thereby resulting in time consuming, cost intensive, low throughput sample procedures. The chapters herein present a unique, simple, cost-efficient, single-step cleanup method for limited sample amounts that allows for the sensitive and selective quantitation of both low and highly chlorinated PCB congeners via a novel extraction method for brain and liver using the Phenomenex PHREE 96-well plate and gas chromatograph tandem-mass spectrometry system. Furthermore, this analytical method holds important implications for the detection of low level exposure of persistent organic pollutants in complex biological matrices. Thus, this research lays the foundation for the future evaluation of physiologically relevant PCB congeners as neurodevelopmental toxicants.
Author | : |
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Total Pages | : 1860 |
Release | : 1997 |
Genre | : Medicine |
ISBN | : |
Author | : Lawrence P. Burkhard |
Publisher | : |
Total Pages | : 450 |
Release | : 1979 |
Genre | : Polychlorinated biphenyls |
ISBN | : |
Author | : J. C. Duinker |
Publisher | : |
Total Pages | : 52 |
Release | : 1984 |
Genre | : Science |
ISBN | : |
The Core Group's recommendations were adopted at the Fourth Session of GEMSI (Curacao, 25-31 March 1982), and it was further decided that, to increase the cost effectiveness of the proposed six-month activity noted above, a detailed report would be given on the results obtained during the preliminary period with respect to identification of individual PCB components by gas chromatography and gas chromatography-mass spectrometry as well as to the distribution of individual components between solution and particulate matter. This is the subject of this publication. The methods described here are also appropriate for the estimation of several other halogenated hydrocarbons in seawater. Some of these compounds appear in the same fraction as PCB (e.g. penta- and hexa-chlorobenzene); for the estimation of more polar components, additional GC-ECD analyses are required. The extracts needed for this purpose require only relatively small additional steps in the separation procedures.
Author | : |
Publisher | : |
Total Pages | : 2454 |
Release | : 2004 |
Genre | : Medicine |
ISBN | : |
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author | : H. T. Won |
Publisher | : |
Total Pages | : 68 |
Release | : 2001 |
Genre | : |
ISBN | : |
"The Canadian Wildlife Service's National Wildlife Research Centre (NWRC) has been providing analytical determinations of chlorinated pesticides and polychlorinated biphenyl (PCB) congeners in wildlife tissues since 1986, in support to its National WildlifeToxicology Program. Starting in 1997, all analytical data were determined using a quadrupole mass selective detector (MSD) coupled to the gas chromatograph instead of the electron capture detector (ECD) system that had been used up to that time. This change has aIIowed the unequivocal identification of a larger number of compounds"--Preface.