The Nicotinic Acetylcholine Receptor
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| Author | : I. Yamamoto |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 300 |
| Release | : 2012-12-06 |
| Genre | : Technology & Engineering |
| ISBN | : 4431679332 |
The nicotinoids are the most important new class of pesticides, joining the organophosphorus compounds, methylcarbamates, and pyrethroids as the major insecticides. Recently, imidacloprid and related nicotinoids have begun replacing organophosphorus and methylcarbamate compounds as insecticides to control insect pests on major crops. Nicotinoids act on the nicotinic acetylcholine receptor, as does naturally occurring nicotine, but with remarkable effectiveness against insects while being safe for mammals; they are quickly degraded and do not persist in the environment. This volume describes the relationship of nicotinoids to botanical insecticidal alkaloids, their discovery and development as insecticides, and the prospects for their expanded use and for the development of resistance. This book is the first to provide concise, comprehensive information on nicotinoids, their chemistry, mode of action, metabolism, and application in agriculture.
| Author | : Steeve Hervé Thany |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 127 |
| Release | : 2011-01-11 |
| Genre | : Medical |
| ISBN | : 1441964452 |
The aim of this book is to summarize our understanding on the insect nicotinic acetylcholine receptors. This area of research received great impetus from the identification of the first subunit sequences to be used as neonicotinoid insecticide target sites. Although a book of this nature can provide the details only of commonly published results, it is hoped that it may provide a useful guide to the newcomer to the field as well as to point out some of the future challenges. For example, we need to determine the precise subunit nomenclature of insect nicotinic receptors. This nomenclature varies amongst species and this led to some of the early confusion that persists. We need to be precise in identifying the subunit composition of native insect nicotinic receptor subtypes, their functional properties and physiological roles.
| Author | : Robin A.J. Lester |
| Publisher | : Springer |
| Total Pages | : 468 |
| Release | : 2014-11-11 |
| Genre | : Medical |
| ISBN | : 1493911678 |
A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.
| Author | : Jeffrey Noebels |
| Publisher | : OUP USA |
| Total Pages | : 1258 |
| Release | : 2012-06-29 |
| Genre | : Medical |
| ISBN | : 0199746540 |
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
| Author | : Constance Hammond |
| Publisher | : Academic Press |
| Total Pages | : 444 |
| Release | : 2014-12-30 |
| Genre | : Medical |
| ISBN | : 0123973228 |
Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. - 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations - Fifteen appendices describing neurobiological techniques are interspersed in the text
| Author | : Edward D Levin |
| Publisher | : CRC Press |
| Total Pages | : 400 |
| Release | : 2019-08-30 |
| Genre | : |
| ISBN | : 9780367390679 |
The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer's, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.
| Author | : F. Clementi |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 837 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642570798 |
Neuronal nicotinic receptors are key molecules for signal transduction in a number of neuronal pathways. They are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer's and Parkinson's dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the field, starting with a historical perspective and dealing with the molecular structure of these receptors, their biophysical and pharmacological properties, their distribution in central and peripheral nervous systems, and their major involvement in brain functions. Particular emphasis is paid to drugs (both new and old) that are useful in the diagnosis and treatment of diseases involving neuronal nicotinic receptors. Finally, the relevance of these receptors in smoking addiction is carefully evaluated, together with future trends and the latest results.
| Author | : P. Michael Conn |
| Publisher | : Academic Press |
| Total Pages | : 778 |
| Release | : 2016-09-28 |
| Genre | : Medical |
| ISBN | : 0128025964 |
Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. - Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance - Features contributions from leading global basic and clinical investigators in the field - Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes - Relates and translates the current science to the understanding of neurological disorders and their treatment
| Author | : Alex S. Evers |
| Publisher | : Cambridge University Press |
| Total Pages | : 2902 |
| Release | : 2011-03-10 |
| Genre | : Medical |
| ISBN | : 1139497022 |
In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.
| Author | : Peter J. Rice |
| Publisher | : Amer Pharmacists Assn |
| Total Pages | : 335 |
| Release | : 2013-11-11 |
| Genre | : Medical |
| ISBN | : 9781582121123 |
Understanding Drug Action: An Introduction to Pharmacology provides readers with a survey of the scientific understanding of drug action. This readable introduction to pharmacology is simple enough to be understood without having to take a class to follow the material, but can also be used to complement a course in pharmacology. The approach to pharmacology is at a basic scientific level to build a framework of how drugs work supplemented with information on some representative drugs that are used clinically. Each chapter includes review questions and many chapters include tables of important drugs with brand and generic names.
