The Neuropharmacology of Alcohol

The Neuropharmacology of Alcohol
Author: Kathleen A. Grant
Publisher: Springer
Total Pages: 625
Release: 2019-03-27
Genre: Medical
ISBN: 3319965239

This volume gives an overview of new insights to alcohol pharmacology using DREADDs (Designer Receptors and Unraveling the Neuropharmacology of Alcohol). It examines which pharmacological principles should be applied to understanding DREADDs taking into account some very current research. Additionally, this book covers important topics under the heading of “experimental pharmacology” and alcohol.

The Pharmacology of Alcohol and Alcohol Dependence

The Pharmacology of Alcohol and Alcohol Dependence
Author: Henri Begleiter
Publisher: Oxford University Press, USA
Total Pages: 544
Release: 1996
Genre: Alcohol
ISBN: 9780195100945

This is a comprehensive review of the pharmacological effects of alcohol and the mechanisms underlying the pathogenesis of alcoholism. The book draws on general pharmacology, neuropharmacology, and alcohol studies to explore its theme. The second volume in the ALCOHOL AND ALCOHOLISM series, it focuses on the pharmacologic mechanisms underlying the development of alcoholism. The first section on basic pharmacology is concerned with those aspects that are common to all of alcohol's effects. These include pharmacokinetics, general metabolism, and cross-tolerance. The second section on neuropharmacology describes the effects of alcohol on various brain functions, including circulation and metabolism. The third section provides an in-depth review of the neurobiology of physical dependence, withdrawal, and physiological tolerance. The book as a whole gives a comprehensive and authoritative picture of the complex pharmacologic actions of alcohol, particularly on the nervous system. For clinicians and researchers in the field of alcohol and alcoholism, it will serve as a fundamental reference.

Biology of the NMDA Receptor

Biology of the NMDA Receptor
Author: Antonius M. VanDongen
Publisher: CRC Press
Total Pages: 368
Release: 2008-10-29
Genre: Medical
ISBN: 142004415X

The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written

The Pharmacology of Alcohol Abuse

The Pharmacology of Alcohol Abuse
Author: Henry R. Kranzler
Publisher: Springer Science & Business Media
Total Pages: 558
Release: 2012-12-06
Genre: Medical
ISBN: 3642784356

The subject of the book is the pharmacology of ethanol. It brings together the work of both basic and clinical investigators in the pharmacology of alcohol and alcohol abuse. The major focus is on the integration of findings from different levels of analysis, together with a discussion of recent insights from molecular biology in terms of their relevance for understanding ethanol's effects and the implications for the development of medications. Comprehensive in its scope, this book provides an up-to-date, in-depth treatment of the field, with particular emphasis on the integration of research findings from diverse approaches and how these findings might influence future investigations.

Alcohol and Opiates

Alcohol and Opiates
Author: Kenneth Blum
Publisher: Elsevier
Total Pages: 430
Release: 2012-12-02
Genre: Medical
ISBN: 0323150802

Alcohol and Opiates: Neurochemical and Behavioral Mechanisms contains the proceedings of the 1976 conference, ""The Neurochemical and Behavioral Mechanisms of Alcohol and Opiate Dependence"", held in New York. The papers focus on the commonalities and distinctions of alcohol and opiates in terms of neurochemical and behavioral mechanisms. It also highlights key research findings on alcohol and drug dependence as well as advances in the understanding of opiate neurochemistry and the nature of alcoholism. Organized into two sections comprised of 22 chapters, this compilation begins with an overview of the various techniques used to produce and to measure alcohol dependence using animal models. It then discusses the neurochemical components of ethanol dependence, the pharmacogenetics of alcoholism, and the effects of alcohol on behavioral performance. The remaining chapters examine the pharmacology of isoquinoline alkaloids and ethanol interactions, the neurochemical aspects of opiate dependence, the pharmocological heterogeneity of narcotic receptors, and the pharmacology of endogenous opiate-like peptides. The book also introduces the reinforcement of behavior by morphine injections and the metabolic stereospecificity of opiate agonist and antagonist drugs. It concludes with an assessment of future research directions concerning opioid peptides (endorphins). This book is a valuable source of information for those seeking to build clinical programs designed to alleviate the sociological and medical ills associated with alcohol and opiate abuse and drug dependency.

Handbook of the Medical Consequences of Alcohol and Drug Abuse

Handbook of the Medical Consequences of Alcohol and Drug Abuse
Author: John Brick
Publisher: Routledge
Total Pages: 748
Release: 2012-04-05
Genre: Medical
ISBN: 1136864571

The essential newly-expanded reference that needs to be on the desk of every health care professional who encounters substance abusers. Handbook of the Medical Consequences of Alcohol and Drug Abuse, Second Edition is the newly-updated classic reference text that provides even more detailed and expanded information on the pharmacological, toxicological, and neuropsychological consequences of alcohol and drug abuse. Eight new chapters of crucial information have been added. Written by leading experts in the fields of medical physiology, psychopharmacology, and neuropsychology, this valuable resource provides the detailed alcohol and drug information health professionals in all fields need to know. Handbook of the Medical Consequences of Alcohol and Drug Abuse, Second Edition greatly expands on the expert information provided in the first edition. This text provides reviews of the cardiovascular, neurological, pulmonary, gastrointestinal, psychological, and hepatic effects of commonly abused drugs. The book also provides in-depth explanations of the mechanisms by which these psychoactive drugs exert their biobehavioral effects as well as current thinking about—and definitions of—abuse, dependence, and alcohol/drug use. The Handbook of the Medical Consequences of Alcohol and Drug Abuse, Second Edition includes vital information on: alcohol, including definitions of alcohol use, abuse, and dependence the relationship between alcohol and accidental injuries, alcohol’s effect on skeletal and major organ systems, and its effect on risk factors for certain cancers effects of alcohol and other drugs on neuropsychological function the effects of alcohol on neuron signaling, neurotransmitter function, and alcoholic brain damage and cognitive dysfunction fetal alcohol effects chronic effects of marijuana use on psychological and physical health, including a fair and balanced discussion of the medical marijuana issue the consequences of opiate abuse and methadone pharmacotherapy, including a comparison of the effects of methadone and heroin on organ systems cocaine’s history, the various forms of the drug, and the adverse effects of cocaine on cardiovascular, neurologic, and pulmonary systems the medical consequences of inhalants ranging from benzene to xylene the prenatal effects of nicotine, cocaine, marijuana, and opiates terminology that appears in the current literature on alcohol New topics in the Handbook of the Medical Consequences of Alcohol and Drug Abuse, Second Edition include chapters discussing: chemical dependency in psychiatric patients medical consequences of steroids OTC medications hallucinogens health effects of tobacco, nicotine, and exposure to tobacco smoke interactions of alcohol with other drugs and other medications periodontal effects of alcohol and drug abuse in the oral cavity imaging studies of structural brain changes The Handbook of the Medical Consequences of Alcohol and Drug Abuse, Second Edition is an invaluable resource for physicians, scientists, nurses, psychologists, and alcohol and drug counselors.

Neurobiology of Alcohol Dependence

Neurobiology of Alcohol Dependence
Author: Antonio Noronha
Publisher: Elsevier
Total Pages: 573
Release: 2014-05-02
Genre: Science
ISBN: 0124071554

Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence. Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available

Addiction and Brain Damage

Addiction and Brain Damage
Author: Derek Richter
Publisher: Routledge
Total Pages: 308
Release: 2016-10-14
Genre: Psychology
ISBN: 1315454041

Originally published in 1980, recent research had produced new insights into how, at the biochemical level, alcohol and other drugs of abuse can impair metabolic and neuropsychiatric functions. Epidemiological studies were also demonstrating that even moderate drinking or drug abuse can produce significant brain damage. This book draws together the latest biochemical, physiological and clinical research on these topics at the time. The initial chapters discuss how alcohol can interfere with various functions: the adaptability of metabolic processes as governed by the ability of the liver to synthesise new enzymes, cell membrane transport, nervous transmission and the transport of nutrients into the brain. It is suggested that opiates, and possibly alcohol, may affect the endorphin system by blocking the uptake of specific amino acids. The second half of the book reports clinical investigations using biochemical studies, psychological tests, EEG investigations and Computerised Axial Tomography (CAT) scanning. It gives the first report of a long-term study by Lishman and co-workers using an improved tomography technique to assess brain damage in alcoholics. These studies give convincing evidence that heavy drinking, even at socially-acceptable levels, can cause serious brain damage in vulnerable people.