The Molecular And Cellular Basis Of Neurodegenerative Diseases
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| Author | : Michael S. Wolfe |
| Publisher | : Academic Press |
| Total Pages | : 561 |
| Release | : 2018-03-29 |
| Genre | : Medical |
| ISBN | : 0128113057 |
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts
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| Release | : 1995 |
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| Author | : Marie-Francoise Chesselet |
| Publisher | : |
| Total Pages | : 428 |
| Release | : 2014-01-15 |
| Genre | : |
| ISBN | : 9781468496024 |
| Author | : Thomas Müller |
| Publisher | : MDPI |
| Total Pages | : 230 |
| Release | : 2019-10-14 |
| Genre | : Science |
| ISBN | : 3039215485 |
The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research.This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included.The objective is to bridge the currently increasing gap between experimental and clinical research on Parkinson's disease and related disorders.
| Author | : Gary Fiskum |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 469 |
| Release | : 2013-11-11 |
| Genre | : Science |
| ISBN | : 1489902090 |
Proceedings of the Fifteenth Washington International Spring Symposium held at The George Washington University, Washington, D.C., May 15-17, 1995
| Author | : Nicholas M Boulis |
| Publisher | : Academic Press |
| Total Pages | : 337 |
| Release | : 2017-01-18 |
| Genre | : Psychology |
| ISBN | : 0128025247 |
Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy
| Author | : Marie-Francoise Chesselet |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 416 |
| Release | : 2000-10-19 |
| Genre | : Medical |
| ISBN | : 1592590063 |
With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.
| Author | : Dennis Dickson |
| Publisher | : John Wiley & Sons |
| Total Pages | : 497 |
| Release | : 2011-09-09 |
| Genre | : Medical |
| ISBN | : 1444341235 |
Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.
| Author | : Ramkumar Mathur |
| Publisher | : Frontiers Media SA |
| Total Pages | : 138 |
| Release | : 2024-01-25 |
| Genre | : Science |
| ISBN | : 2832543499 |
Age-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuroinflammation as well as neuronal degeneration. Apoptosis, necrosis, and autophagy are all types of programmed cell death that are morphologically distinct from one another. Over the last decade, extensive research has been conducted on necroptosis, resulting in a better understanding of its molecular underpinnings and role in neurodegenerative diseases. A later study investigates the processes of apoptosis and necroptosis, as well as their roles in the activation of inflammatory immune responses. Although there is a distinct mode of cell death with distinct morphological characteristics, its identification and implications in neurological diseases are still unknown. Interestingly, emerging evidence has established a direct link between epigenetic and posttranslational modifications and neurodegenerative disease. Using epigenetic and proteomic methods, researchers uncovered genes and proteins that may play a function in the area of neuroinflammation, a role that has hitherto been overlooked. New pharmacological targets and therapeutic options for neurodegenerative diseases are being investigated in order to gain a better understanding of the disease's origins and progression by using neuronal death and neuroinflammation models that are associated with epigenetic changes.
| Author | : Patrick A. Lewis |
| Publisher | : Academic Press |
| Total Pages | : 274 |
| Release | : 2018-11-16 |
| Genre | : Science |
| ISBN | : 0128110708 |
The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models
