The purpose of this study was to examine the relationship between oral reading fluency and reading comprehension through the lens of developing readers in an actual classroom setting. In order to provide targeted fluency instruction, the study implemented the Fluency Development Lesson (FDL), a widely recognized and research-based instructional framework for fluency development, to analyze its impact on the reading comprehension of students in a second grade classroom. The study was conducted in a suburban school district located in a Midwestern state. Twenty-two students between seven and nine years old took part in the study by participating in the FDL daily from September through January. The participant sample employed was a purposeful, nonprobability sample. The researcher was the classroom teacher. The data were collected and analyzed using the 3-Minute Reading Assessment: Word Recognition, Fluency and Comprehension to generate the following scores: (a) word recognition accuracy; (b) automaticity in reading fluency; (c) multidimensional fluency skills including expression and volume, phrasing and intonation, smoothness, and pace; and (d) retelling comprehension. The organization of data for this study determined the statistical significance of change and the existence of a correlation between oral reading fluency and comprehension among the second grade students using the analysis of repeated measures and the Pearson's r statistical test. Findings from the data suggested that with regular use of the FDL, significant statistical improvements were seen in retelling comprehension, words read correctly per minute, expression and volume, phrasing and intonation, smoothness, and pace in reading. In this study, the FDL proved to be an effective way of improving students' reading performance in fluency and comprehension skills. In conclusion, using the FDL in the classroom has the potential to provide positive outcomes for student reading fluency and ultimately in overall reading achievement. As educators attempt to find ways to achieve proficiency in reading, they will hopefully take into account the implications of this study and any past and future studies that demonstrate the positive benefits of using the FDL with their students to improve fluency and comprehension skills.