The Great Protector of Wits provides a new assessment of baron d’Holbach (1723–1789) and his circle. A challenging figure of the European Enlightenment, Paul-Henri Thiry d’Holbach was not only a radically materialistic philosopher, a champion of anticlericalism, the author of the Système de la nature – known as ‘the Bible of atheists’ –, an idéologue, a popularizer of the natural sciences and a prolific contributor to the Encyclopédie, but he also played a crucial role as an organizer of intellectual networks and was a master of disseminating clandestine literature and a consummate strategist in authorial fictions. In this collective volume, for the first time, all these different threads of d’Holbach’s ‘philosophy in action’ are considered and analyzed in their interconnection. Contributors to this volume: Jacopo Agnesina, Nicholas Cronk, Mélanie Éphrème, Enrico Galvagni, Jonathan Israel, Alan Charles Kors, Mladen Kozul, Brunello Lotti, Emilio Mazza, Gianluca Mori, Iryna Mykhailova, Gianni Paganini, Paolo Quintili, Alain Sandrier, Ruggero Sciuto, Maria Susana Seguin, and Gerhardt Stenger.