The Emergence of Drugs which Block Calcium Entry
Author | : Ronald D. Smith |
Publisher | : Springer |
Total Pages | : 174 |
Release | : 1988 |
Genre | : Medical |
ISBN | : |
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Author | : Ronald D. Smith |
Publisher | : Springer |
Total Pages | : 174 |
Release | : 1988 |
Genre | : Medical |
ISBN | : |
Author | : Ronald D Smith |
Publisher | : |
Total Pages | : 168 |
Release | : 1988-04-25 |
Genre | : |
ISBN | : 9783642732294 |
Author | : Ronald D. Smith |
Publisher | : Springer Science & Business Media |
Total Pages | : 163 |
Release | : 2013-03-07 |
Genre | : Medical |
ISBN | : 3642732283 |
Calcium Entry Blockers (CEBs) are a new class of drugs which have been pushing back the frontiers of science and medicine for almost two decades. This report reviews some of the wealth of chemical, biological and clinical data describing the discovery and development of these compounds. The scientific importance, therapeutic benefit and marketing potential of these compounds have caused an explosion of scientific literature describing their effects in many preclinical and clinical settings. The definitional characteristics of these compounds suggest a certain predictability of their biological profile but their therapeutic usefulness varies widely dependent upon their physical properties, net hemodynamic effects, duration of action and incidence of side effects. CEBs appear uniquely suited to the treatment of the underlying complexity of cardiovascular disease. The CEBs of the future may live up to the expectations of pathophysiologically based therapeutics and allow the heart and blood vessels to outlive the cells which they support. The development of CEBs is an evolving story of epic proportions and represents the cooperative efforts of individuals in all areas of science.
Author | : Juliusz Ashot Kozak |
Publisher | : CRC Press |
Total Pages | : 343 |
Release | : 2017-07-14 |
Genre | : Science |
ISBN | : 149875273X |
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Author | : Théophile Godfraind |
Publisher | : Birkhäuser |
Total Pages | : 269 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3034878591 |
The main effect of calcium channel blockers is the blockade of calcium entry into cells through voltage operated calcium channels. This volume gives a comprehensive overview of the different classes of CCBs and their various effects. It covers historical development, pharmacology, clinical aspects, and perspectives. All chapters are written by Prof. T. Godfraind, a world leading expert in the field.
Author | : Symposium on the Role of Calcium Entry Blocking Drugs in Hypertension (1985) |
Publisher | : |
Total Pages | : 111 |
Release | : 1985 |
Genre | : |
ISBN | : |
Author | : Jeffrey K. Aronson |
Publisher | : Elsevier |
Total Pages | : 7629 |
Release | : 2015-10-15 |
Genre | : Medical |
ISBN | : 0444537163 |
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, Sixteenth Edition, Seven Volume Set builds on the success of the 15 previous editions, providing an extensively reorganized and expanded resource that now comprises more than 1,500 individual drug articles with the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature, making this a must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company. The online version of the book provides an unparalleled depth of coverage and functionality by offering convenient desktop access and enhanced features such as increased searchability, extensive internal cross-linking, and fully downloadable and printable full-text, HTML or PDF articles. Enhanced encyclopedic format with drug monographs now organized alphabetically Completely expanded coverage of each drug, with more than 1,500 drug articles and information on adverse reactions and interactions Clearer, systematic organization of information for easier reading, including case histories to provide perspective on each listing Extensive bibliography with over 40,000 references A must–have reference work for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary, or pharmaceutical company
Author | : Hyman J. Zimmerman |
Publisher | : Lippincott Williams & Wilkins |
Total Pages | : 848 |
Release | : 1999 |
Genre | : Medical |
ISBN | : 9780781719520 |
Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Author | : |
Publisher | : Academic Press |
Total Pages | : 307 |
Release | : 2013-07-24 |
Genre | : Science |
ISBN | : 0124079385 |
Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject
Author | : Neil Kaplowitz |
Publisher | : CRC Press |
Total Pages | : 790 |
Release | : 2002-10-16 |
Genre | : Medical |
ISBN | : 0203909127 |
Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines.